3 research outputs found
COVID-19 Infection in Chronic Myeloid Leukemia Patients Receiving Tyrosine Kinase Inhibitor in Makassar, Indonesia: A Six-Case Report and Literature Review
No full textManagement of chronic myeloid leukemia (CML) in patients who are infected with COVID-19 is a challenging task due to disease-related or treatment-related factors that place such patients at a higher risk of complications. However, a low-infectivity-rate mechanism has been proposed by some researchers. In CML patients with COVID-19 infection, the most important treatment-related factor involves tyrosine kinase inhibitors (TKIs). In this case report, six patients with chronic-phase CML who experienced COVID-19 of mild–moderate severity all continued to receive TKI treatment for CML concurrently with COVID-19 treatment. All patients fully recovered. In the present study, we also review four other cases of COVID-19 infection in CML patients. Outcomes for TKI-treated CML patients who contract COVID-19 are influenced by many factors. Tyrosine kinase inhibitor therapy may benefit CML patients due to its antiviral effect, but the interaction between TKIs and drugs used for COVID-19 treatment requires careful monitoring. An individual approach is needed in every case
Factors affecting hematological abnormality in HIV-infected patients at Dr. Wahidin Sudirohusodo Hospital Makassar, Indonesia
No full textIntroduction
Human immunodeficiency virus (HIV) is characterized by a progressive damage of immune system, resulting in a number of opportunistic infections and hematological abnormalities, and become more severe in late stages. Hematological abnormalities are common manifestations, with factors including CD4+ count, opportunistic infection, and HIV viral load. The aim of this study was to investigate the correlation between CD4+ count, opportunistic infection, and HIV viral load with hematological abnormality in HIV patients.
Material and methods
An observational study was conducted at tertiary institution, Dr. Wahidin Sudirohusodo Hospital, Makassar, from November 2021 to February 2022. Secondary data from medical records of HIV-infected patients were used. Chi-square test and independent t-test were employed to determine the correlation between CD4+ count, opportunistic infection, and HIV viral load with hematological abnormality.
Results
Among 83 HIV subjects, anemia was present in 47% of the cases. Leucopenia, lymphopenia, and thrombocytopenia were observed in 10.8%, 28.9%, and 9.6%, respectively. Anemia and lymphopenia significantly correlated with CD4+ count (p 0.05), between anemia and lymphopenia with opportunistic infection and co-infection (p > 0.05), and between anemia, leucopenia, lymphopenia, and thrombocytopenia with viral load (p > 0.05).
Conclusions
Anemia and lymphopenia significantly correlated with CD4+ count. CD4+ count monitoring is needed for early detection of hematological abnormalities in order to lower morbidity and increase quality of life
Клинический случай сочетанного течения COVID-19 и тропической малярии
No full text The global outbreak of the new coronavirus infection COVID-19 is still ongoing, leading to coinfections such as malaria and COVID-19 and others. As evidenced by the increase in various reports of coinfections. In recent years, Uzbekistan has achieved epidemiological stability for malaria and in 2018 received an official World Health Organization certificate confirming the country’s “malaria-free” status. At the present stage during the COVID-19 pandemic, imported malaria from abroad is relevant for our republic and, therefore, there is a constant danger of renewed transmission from imported cases. In this article presented the clinical case of coinfection of COVID-19 and malaria in a patient. From the epidemiological data, the patient was a citizen of Cameroon. During treatment of coronavirus infection, the patient noted intermittent chills all over the body and sweating, clinical symptoms of tropical malaria began to appear. Microscopy of a thick drop and a thin blood smear confirmed the presence of Pl. falciparum. The patient was prescribed antimalarial therapy with mefloquine, resulting in clinical recovery. Глобальная вспышка новой коронавирусной инфекции COVID-19 все еще продолжается, что приводит к появлению сочетанных заболеваний, таких как малярия и COVID-19 и др., что подтверждается ростом различных сообщений о регистрации коинфекций. В последние годы Узбекистан добился эпидемиологической стабильности по малярии и в 2018 г. получил официальный сертификат Всемирной организации здравоохранения, подтверждающий статус страны, «свободной от малярии». На современном этапе в период пандемии COVID-19 для нашей республики актуальной является завозная малярия из-за рубежа и, следовательно, наличие постоянной опасности возобновления передачи инфекции от завозных случаев. Представлено клиническое наблюдение совместного течения новой коронавирусной инфекции и тропической малярии у больного 2003 г. р. Из эпидемиологического анамнеза: больной был гражданином Камеруна, на фоне лечения от коронавирусной инфекции больной отмечал периодический озноб по всему телу и потливость, начали проявляться клинические симптомы тропической малярии. Микроскопия толстой капли и тонкого мазка крови подтвердила наличие Pl. falciparum. Больному была назначена противомалярийная терапия мефлохином, в результате чего наступило клиническое выздоровление
