8,040 research outputs found
George C. Martin Papers - Accession 271 - M117 (149-150)
No full textThe George C. Martin Papers includes Civil War correspondence between George Canning Martin and his wife, Sarah Jane, from May 1862 to August 1864. Subjects include camp life, the progress of the war in North Carolina and Virginia, and the physical and mental condition of the Confederate soldiers (such as ill health, poor food, and depression). Also included are tax receipts, pension records, newspapers clippings (1863), a commonplace book belonging to Robert Smith, and a memoir (author unknown).https://digitalcommons.winthrop.edu/manuscriptcollection_findingaids/1290/thumbnail.jp
POLITICAL ISLAM: Asking the Wrong Questions?
No full textThe empirical literature on political Islam is fairly rich and getting better, but theoretical interpretations of these data are still quite primitive. This gap is a product of Orientalist traditions that essentialize Islamic movements, a resulting lack of appreciation for their global diversity, and the inevitable politicization of the subject matter. This essay seeks not only to identify the most important studies in the field but to show how they suggest a typology, chronology, and problematic that might lead to more fruitful analysis in the future.ABDELMALEK A, 1963, DIOGENES, V44, P107; ABRAHAMIAN E, KHOMEINISM ESSAYS IS; Abrahamian Ervand, 1989, IRANIAN MOJAHEDIN; Abun-Nasr Jamil M., 1965, TIJANIYYA SUFI ORDER; Adelkhah Fariba, 2000, BEING MODERN IRAN; Ahmed A. S., 1992, POSTMODERNISM ISLAM; Akhavi Shahrough, 1980, RELIG POLITICS CONT; Almond G., 2003, STRONG RELIG RISE FU; Amir Rana Muhammad, 2004, A Z JEHADI ORG PAKIS; Ammerman Nancy T, 1987, BIBLE BELIEVERS FUND; [Anonymous], 2005, ECONOMIST; Arjomand Said Amir, 1989, TURBAN CROWN ISLAMIC; Auty R, 1993, SUSTAINING DEV MINER; Ayubi N., 1993, POLITICAL ISLAM RELI; Bayat Mangol, 1982, MYSTICISM DISSENT SO; BAYULGEN O, 2005, BUSINESS POLIT, P7; Berman Paul, 2003, TERROR LIBERALISM; Blanchard Christopher M, 2005, AL QAEDA STATEMENTS; Bowen John, 2003, ISLAM LAW EQUALITY I; Buehler Arthur F., 1998, SUFI HEIRS PROPHET I; BURKE J, 2004, ALQAEDA TRUE STORY R; Carapico Sheila, 1998, CIVIL SOC YEMEN POLI; Carpenter Joel A., 1997, REVIVE US AGAIN REAW; Chehabi Houchang, 1990, IRANIAN POLITICS REL; Cleveland William, 1985, ISLAM W SHAKIB ARSLA; Cole J., 1986, SHIISM SOCIAL PROTES; Crenshaw M., 1994, TERRORISM CONTEXT; Crystal Jill, 1990, OIL POLITICS GULF RU; Davis JM, 2003, MARTYRS: INNOCENCE, VENGEANCE, AND DESPAIR IN THE MIDDLE EAST, P1; *DEF SCI BOARD, 2004, TASK FORC STRAT COMM; DELCASTLLO D, 2001, CHRON HIGHER ED 0928, pA19; DELONG J, 2001, DEALING ISLAMIC REFO; Delong-Bas N. J., 2004, WAHHABI ISLAM REVIVA; Duverger M, 1954, POLITICAL PARTIES TH; ECIKELMAN D, 1996, MUSLIM POLITICS; EICKELMAN D, 1975, MOROCCAN ISLAM TRADI; Eickelman Dale F., 1985, KNOWLEDGE POWER MORO; ELLENS H, 2003, DESTRUCTIVE POWER RE, V1; Esmer Y., 2003, HUMAN VALUES SOCIAL, P35; Esposito J.L., 2001, MAKERS CONT ISLAM; FANDY M, 2001, SUADI ARABIA POLITIC; Fischer M. M. J., 1980, IRAN RELIG DISPUTE R; FORAN J, 1994, CENTURY REVOLUTIONS; Geertz Clifford, 1971, ISLAM OBSERVED RELIG; Geertz Clifford, 1976, RELIG JAVA; Gellner Ernest, 1994, CONDITIONS LIBERTY C; Gellner Ernest, 1977, PATRONS CLIENTS MEDI; GILSENAN M, 1983, RECOGNIZING ISLAM AN; HAMDI M, 1998, MAKING ISLAMIC LEADE; Hammoudi A., 1997, MASTER DISCIPLE CULT; HAMZEDH A, 2004, PATH HIZBULLAH; Harik Judith Palmer, 2004, HEZBOLLAH CHANGING F; HEFNER R, 2004, REMAKIGN MUSLIM POLI; Hefner R.W., 2000, CIVIL ISLAM MUSLIMS; Henry C. M., 2001, GLOBALIZATION POLITI; Hermansen Marcia, 1995, CONCLUSIVE ARGUMENT; Hooker M.B., 2003, INDONESIAN ISLAM SOC; Hudson Rex A., 2002, WHO BECOMES TERRORIS; Huntington S.P, 1995, CLASH CIVILIZATIONS; Inglehart Ronald, 2003, FOREIGN POLICY MAR, P67; JAHANBAKSH F, 2001, ISLAM DEMOCRACY MODE; Kalyvas SN, 2006, CAMB STUD COMPAR, P1, DOI 10.1017-CBO9780511818462; Karl T. L., 1997, PARADOX PLENTY OIL B; Kazemi Farhad, 1980, POVERTY REVOLUTION I; KEDIE N, 1972, SCH SAINTS SUFIS MUS; Kedourie Elie, 1994, DEMOCRACY ARAB POLIT; Kepel Gilles, 2003, JIHAD TRAIL POLITICA; Khalid Adeeb, 1999, POLITICS MUSLIM CULT; Kim Younkyoo, 2003, RESOURCE CURSE POSTC; KIMBALL C, 2002, WHEN RELIG BECOMES E; Kuczynski P-P, 2003, WASHINGTON CONSENSUS; KURZMAN C, 1998, LIBERAL ISLAM SOUREB; Lewis Bernard, 2002, WHAT WENT WRONG CLAS; Lewis Bernard, 1990, ATLANTIC MONTHLY, V266, P47; Lindqvist Sven, 2003, HIST BOMBING; LIPSET SM, 1959, AM POLIT SCI REV, V53, P69, DOI 10.2307-1951731; Lockman Zachary, 2004, CONTENDING VISIONS M; Luciani G., 1990, ARAB STATE; MAJID A, 2000, UNVEILING ISLAM POST; Mandaville P, 2001, TRANSNATIONAL MUSLIM; MARLIN R, 2004, WHAT DOES ALQAEDA WA; MARTIN W, 1996, GOD OUR SIDE RISE RL; Marty M.E., 1991, FUNDAMENTALISMS OBSE; Masud Muhammad Khalid, 2000, TRAVELLERS FAITH STU; McDermott Terry, 2005, PERFECT SOLDIERS HIJ; McKenna T, 1998, MUSLIM RULERS REBELS; Mitchell Richard, 1993, SOC MUSLIM BROTHERS; Moaddel M, 2002, JORDANIAN EXCEPTIONA; MOORE RI, 1991, FORMATION PERSECUTIN; Moslem Mehdi, 2002, FACTIONAL POLITICS P; MOUSSALLI A, 1993, RADICAL ISLAMIC FUND; Nakash Yitzhak, 2003, SHIIS IRAQ; NASR S, 1996, MAWDUDI MAKIGN ISLAM; Nasr S.V, 1994, VANGUARD ISLAMIC REV; Navaro-Yashin Y., 2002, FACES STATE SECULARI; Nirenberg David, 1998, COMMUNITIES VIOLENCE; NOMANI F, 1994, ISLAMIC EC SYSTEMS; Paden J., 1973, RELIG POLITICAL CULT; Pape Robert, 2005, DYING WIN STRATEGIC; Peletz Michael G., 2002, ISLAMIC MODERN RELIG; *PEW GLOB ATT SURV, 2005, ISL EXT COMM CONC MU; Rahnema Ali, 2000, ISLAMIC UTOPIAN POLI; Rashid Ahmed, 2000, TALIBAN MILITANT ISL; Reed Steven R., 1993, MAKING COMMON SENSE; Riesebrodt Martin, 1993, PIOUS PASSION EMERGE; Rizvi S. A. A., 1980, SHAH WALI ALLAH HIS; ROBERS P, 2004, END OIL EDGE PERILOU; Ross ML, 2001, WORLD POLIT, V53, P325, DOI 10.1353-wp.2001.0011; Roy O., 1994, FAILURE POLITICAL IS; Roy O., 2004, GLOBALIZED ISLAM SEA; ROY O, 1990, ISLAM RESISTASNCE AF; Roy Olivier, 2004, ISLAMIST NETWORKS AF; RUTHVEN M, 1986, ISLAM WORLD; Sadowski YM, 1998, MYTH GLOBAL CHAOS; Sageman M, 2004, UNDERSTANDING TERROR NETWORKS, P1; Said Edward, 2002, HARPERS MAGAZINE JUL, P69; Said Edward W., 1978, ORIENTALISM; Schatz Edward, 2004, MODERN CLAN POLITICS; Schwedler J., 1995, CIVIL SOC MIDDLE E P; SEVASTOPULO D, 2005, FINANC TIMES 0706; Simmons M., 2005, TWILIGHT DESERT COMI; Simone T. A. M., 1994, WHOSE IMAGE POLITICA; Stepan A, 2003, J DEMOCR, V14, P30, DOI 10.1353-jod.2003.0064; STERN J, 2003, TERROR NAME GOD RELI; TAMMAM H, 2003, MONDE DIPL; VARSHNEYA, 2003, ETHNIC CONFLICT CIVI; Verkaaik O., 2004, MIGRANTS MILITANTS F; Victor Barbara, 2003, ARMY ROSES INSIDE WO; Voll John O., 1994, ISLAM CONTINUITY CHA; Wickham Carrie Rosefsky, 2002, MOBILIZING ISLAM REL; WIKTOROWICZ Q, 2001, MANAGEMETN ISLAMIC A; Wiktorowicz Quintan, 2004, ISLAMIC ACTIVISM SOC; Wiktorowicz Quintan, 2001, MANAGEMENT ISLAMIC A; Wilcox Clyde, 2000, ONWARD CHRISTIAN SOL; WUTHNOW R, SAVING AM FAITH BASE; Yassini Ayman Al, 1985, RELIG STATE KINGDOM; Yavuz M.H., 2003, TURKISH ISLAM SECULA; YAVUZ MH, 2001, ISLAMIC POLITICAL ID; Zaman M. Q., 2002, ULAMA CONT ISLAM CUS; ZOGBY J, 2002, IMPRESSIONS AM; Zogby James, 2002, WHAT ARABS THINK109
The role of the yeast cleavage and polyadenylation factor subunit Ydh1p/Cft2p in pre-mRNA 3'-end formation
No full textCleavage and polyadenylation factor (CPF) is a multi-protein complex that functions in pre-mRNA 3'-end formation and in the RNA polymerase II (RNAP II) transcription cycle. Ydh1p/Cft2p is an essential component of CPF but its precise role in 3'-end processing remained unclear. We found that mutations in YDH1 inhibited both the cleavage and the polyadenylation steps of the 3'-end formation reaction in vitro. Recently, we demonstrated that an important function of CPF lies in the recognition of poly(A) site sequences and RNA binding analyses suggesting that Ydh1p/Cft2p interacts with the poly(A) site region. Here we show that mutant ydh1 strains are deficient in the recognition of the ACT1 cleavage site in vivo. The C-terminal domain (CTD) of RNAP II plays a major role in coupling 3'-end processing and transcription. We provide evidence that Ydh1p/Cft2p interacts with the CTD of RNAP II, several other subunits of CPF and with Pcf11p, a component of CF IA. We propose that Ydh1p/Cft2p contributes to the formation of important interaction surfaces that mediate the dynamic association of CPF with RNAP II, the recognition of poly(A) site sequences and the assembly of the polyadenylation machinery on the RNA substrate
Differential molecular chaperone response associated with various mouse adapted scrapie strains
No full textPrionoses are a group of neurodegenerative diseases characterized by misfolding of cellular prion protein (PrP(C)) and accumulation of its diseases specific conformer PrP(Sc) in the brain and neuropathologically, they can be associated with presence or absence of PrP amyloid deposits. Functional molecular chaperones (MCs) that constitute the unfolded protein response include heat shock proteins and glucose-regulated protein families. They protect intracellular milieu against various stress conditions including accumulation of misfolded proteins and oxidative stress, typical of neurodegenerative diseases. Little is known about the role of MCs in pathogenesis of prionoses in mammalian prion model systems. In this study we characterized MCs response pattern in mice infected with various mouse adapted scrapie strains. Rather than uniform upregulation of MCs, we encountered two distinctly different patterns of MCs response distinguishing ME7 and 87V strains from 22L and 139A strains. ME7 and 87V strains are known for the induction of amyloid deposition in infected animals, while in mice infected with 22L and 139A strains amyloid deposits are absent. MCs response pattern similar to that associated with amyloidogenic ME7 and 87V strains was also observed in APPPS1-21 Alzheimer's transgenic mice, which represent an aggressive model of cerebral amyloidosis caused by ?-amyloid deposition. Our results highlight the probability that different mechanisms of MCs regulation exist driven by amyloidogenic and non-amyloidogenic nature of prion strains
Martin Andersen Nexø
No full textThis is a short presentation of the main works of the Danish author Martin Andersen Nexø
Lockheed Martin Dedication Ceremony of the John C. Stennis Space Center
No full textLockheed Martin Dedication Ceremony of the John C. Stennis Space Center with Roy Estess, Bill Hansen, Ronnie Musgrove, Trent Lott, Gene Taylor, and Roderick Pullman
Independent functions of yeast Pcf11p in pre-mRNA 3' end processing and in transcription termination
No full textSadowski M, Dichtl B, Hübner W, Keller W. Independent functions of yeast Pcf11p in pre-mRNA 3' end processing and in transcription termination. The EMBO journal. 2003;22(9):2167-2177.Pcf11p, an essential subunit of the yeast cleavage factor IA, is required for pre-mRNA 3' end processing, binds to the C-terminal domain (CTD) of the largest subunit of RNA polymerase II (RNAP II) and is involved in transcription termination. We show that the conserved CTD interaction domain (CID) of Pcf11p is essential for cell viability. Interestingly, the CTD binding and 3' end processing activities of Pcf11p can be functionally uncoupled from each other and provided by distinct Pcf11p fragments in trans. Impaired CTD binding did not affect the 3' end processing activity of Pcf11p and a deficiency of Pcf11p in 3' end processing did not prevent CTD binding. Transcriptional run-on analysis with the CYC1 gene revealed that loss of cleavage activity did not correlate with a defect in transcription termination, whereas loss of CTD binding did. We conclude that Pcf11p is a bifunctional protein and that transcript cleavage is not an obligatory step prior to RNAP II termination
The SF-36: a simple, effective measure of mobility disability for epidemiological studies
No full textBackgroundMobility disability is a major problem in older people. Numerous scales exist for the measurement of disability but often these do not permit comparisons between study groups. The physical functioning (PF) domain of the established and widely used Short Form-36 (SF-36) questionnaire asks about limitations on ten mobility activities.ObjectivesTo describe prevalence of mobility disability in an elderly population, investigate the validity of the SF-36 PF score as a measure of mobility disability, and to establish age and sex specific norms for the PF score.MethodsWe explored relationships between the SF-36 PF score and objectively measured physical performance variables among 349 men and 280 women, 59-72 years of age, who participated in the Hertfordshire Cohort Study (HCS). Normative data were derived from the Health Survey for England (HSE) 1996.Results32% of men and 46% of women had at least some limitation in PF scale items. Poor SF-36 PF scores (lowest fifth of the gender-specific distribution) were related to: lower grip strength; longer timed-up-and-go, 3m walk, and chair rises test times in men and women; and lower quadriceps peak torque in women but not men. HSE normative data showed that median PF scores declined with increasing age in men and women.ConclusionOur results are consistent with the SF-36 PF score being a valid measure of mobility disability in epidemiological studies. This approach might be a first step towards enabling simple comparisons of prevalence of mobility disability between different studies of older people. The SF-36 PF score could usefully complement existing detailed schemes for classification of disability and it now requires validation against them
Economic evaluation of a stratified transport method for Atlantic halibut (Hippoglossus hippoglossus) juveniles
No full textThe objective of this study was to evaluate a convenient, low-cost modification to conventional transfer methods for Atlantic halibut juveniles. A series of wire mesh cages were stacked within transport tanks creating a stratified transport system (STS), increasing the surface area for settlement and facilitating a more homogeneous distribution of halibut throughout the tank compared with the conventional insulated box (Unstructured, UTS). A stochastic cost-benefit analysis determined investment into a STS to be cost-effective, generating a mean benefit-cost ratio of 1.31 (95% CI, 0.68–2.00) after 2 years and a mean 5-year net present value of 85,176(9546,906–$125,630). The implementation of a STS was found to be technically feasible and economically efficient method to improve Atlantic halibut transport.Peter J. Sykes, Carol A. McClure, Debbie J. Martin-Robichaud, Charles G. Caraguel, K. Larry Hammel
Cytotoxic C20 Diterpenoid Alkaloids from the Australian Endemic Rainforest Plant Anopterus macleayanus
No full textIn order to identify new anticancer compounds from nature, a prefractionated library derived from Australian endemic plants was generated and screened against the prostate cancer cell line LNCaP using a metabolic assay. Fractions from the seeds, leaves, and wood of Anopterus macleayanus showed cytotoxic activity and were subsequently investigated using a combination of bioassay-guided fractionation and mass-directed isolation. This led to the identification of four new diterpenoid alkaloids, 6α-acetoxyanopterine (1), 4′-hydroxy-6α-acetoxyanopterine (2), 4′-hydroxyanopterine (3), and 11α-benzoylanopterine (4), along with four known compounds, anopterine (5), 7β-hydroxyanopterine (6), 7β,4′-dihydroxyanopterine (7), and 7β-hydroxy-11α-benzoylanopterine (8); all compounds were purified as their trifluoroacetate salt. The chemical structures of 1–8 were elucidated after analysis of 1D/2D NMR and MS data. Compounds 1–8 were evaluated for cytotoxic activity against a panel of human prostate cancer cells (LNCaP, C4-2B, and DuCaP) and nonmalignant cell lines (BPH-1 and WPMY-1), using a live-cell imaging system and a metabolic assay. All compounds showed potent cytotoxicity with IC50 values of <400 nM; compound 1 was the most active natural product from this series, with an IC50 value of 3.1 nM toward the LNCaP cell line. The live-cell imaging assay on 1–8 showed a concentration- and time-dependent effect on the cell morphology and proliferation of LNCaP cells.Griffith Sciences, Griffith Institute for Drug DiscoveryFull Tex
- …
