191 research outputs found
Placenta's impact factor 2018
No full textAs the Editors of Placenta, we are happy to share with our International Federation of Placenta Associations (IFPA) community and all placenta enthusiasts that the 2018 impact factor (IF) of Placenta, released in June 2019, increased from 2.43 to 2.77. When compared to 2017 data, Placenta's 2018 IF advanced from #16 to #12 in the ranking of reproductive biology journals, and from #29 to #20 among OBGYN journals.Full Tex
The Expression and Localization of N-Myc Downstream-Regulated Gene 1 in Human Trophoblasts
No full textThe protein N-Myc downstream-regulated gene 1 (NDRG1) is implicated in the regulation of cell proliferation, differentiation, and cellular stress response. NDRG1 is expressed in primary human trophoblasts, where it promotes cell viability and resistance to hypoxic injury. The mechanism of action of NDRG1 remains unknown. To gain further insight into the intracellular action of NDRG1, we analyzed the expression pattern and cellular localization of endogenous NDRG1 and transfected Myc-tagged NDRG1 in human trophoblasts exposed to diverse injuries. In standard conditions, NDRG1 was diffusely expressed in the cytoplasm at a low level. Hypoxia or the hypoxia mimetic cobalt chloride, but not serum deprivation, ultraviolet (UV) light, or ionizing radiation, induced the expression of NDRG1 in human trophoblasts and the redistribution of NDRG1 into the nucleus and cytoplasmic membranes associated with the endoplasmic reticulum (ER) and microtubules. Mutation of the phosphopantetheine attachment site (PPAS) within NDRG1 abrogated this pattern of redistribution. Our results shed new light on the impact of cell injury on NDRG1 expression patterns, and suggest that the PPAS domain plays a key role in NDRG1's subcellular distribution. © 2013 Shi et al
Ferroptotic cell death and vesiculation
No full textLive cell imaging of ferroptosis and cell membrane blebbing and vesiculation in BeWo cells that were depleted of PLA2G6 using CRISPR/Cas9 and exposed to a low level of RSL
The biology of extracellular vesicles: The known unknowns.
No full textFor many years, double-layer phospholipid membrane vesicles, released by most cells, were not considered to be of biological significance. This stance has dramatically changed with the recognition of extracellular vesicles (EVs) as carriers of biologically active molecules that can traffic to local or distant targets and execute defined biological functions. The dimensionality of the field has expanded with the appreciation of diverse types of EVs and the complexity of vesicle biogenesis, cargo loading, release pathways, targeting mechanisms, and vesicle processing. With the expanded interest in the field and the accelerated rate of publications on EV structure and function in diverse biomedical fields, it has become difficult to distinguish between well-established biological features of EV and the untested hypotheses or speculative assumptions that await experimental proof. With the growing interest despite the limited evidence, we sought in this essay to formulate a set of unsolved mysteries in the field, sort out established data from fascinating hypotheses, and formulate several challenging questions that must be answered for the field to advance
Intersecting families of permutations
No full textResearch of the second author was supported in part by the Israel Science Foundation, grant no. 0397684, and NSERC grant 341527.
Research of the third author was supported in part by the Giora Yoel Yashinsky Memorial Grant
Developmental and Physiologic Roles of the Nuclear Receptor Steroidogenic Factor-I in the Reproductive System
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