37 research outputs found
SAlexNet: Superimposed AlexNet using Residual Attention Mechanism for Accurate and Efficient Automatic Primary Brain Tumor Detection and Classification
No full textAccurate classification of brain tumors is crucial for informing clinical diagnoses and guiding patient treatment plans. It is one of the most aggressive tumors, leading to a short life expectancy. However, the classification of brain tumors is a challenging task due to the heterogeneity, complexity, and variability of brain tumors. In this work, we propose Superimposed AlexNet (SAlexNet-1 and its extension SAlexNet-2) to detect the malignancy of primary brain tumors (Glioma, Meningioma, and Pituitary) by incorporating three enhancements: (1) fusing Hybrid Attention Mechanism (HAM), (2) dense feature extraction by replacing initial convolution 11 × 11 layer with multiple convolution 3 × 3 layers for extra non-linearity alleviating parameter burden, and (3) pretraining the encoder path on a correlated dataset via semi-transfer learning (STL) enhancing model performance. HAM provides more comprehensive and accurate feature representations. In this study, we evaluated the performance of our proposed SAlexNet models on two publicly available extensive datasets for multi-class and binary classification tasks. Our results show that SAlexNet-1 achieved an accuracy of (98.78 ± 0.80 %) and (98.07± 0.02 %) on the multi-class and binary classification datasets, respectively. In comparison, SAlexNet-2 achieved outstanding accuracy of (99.69 ± 0.22 %) and (99.17 ± 0.00 %) on the multi-class and binary classification MRI datasets, respectively. The STL-based SAlexNet-2 surpassed previous literature with complex models and techniques, achieving an accuracy of (99.20 ± 0.01 %). Furthermore, we provided a comprehensive analysis of current state-of-the-art tumor classification methods on the same dataset, demonstrating the effectiveness of our approach. Enhanced tumor classification accuracy enables better diagnosis, treatment planning, and patient outcomes
Characterization of spliceosome assembly in cyanidioschyzon merolae.
No full textPre-mRNA splicing is the removal of intervening sequences from pre-messenger RNA in a reaction catalyzed by the spliceosome, which contains five small nuclear RNAs (snRNAs) and more than 100 proteins. Assembly of the spliceosome occurs in a highly ordered manner, making the spliceosome a very complex and dynamic particle. The spliceosome has been studied in yeast and humans but a simpler system would simplify splicing studies. Cyanidioschyzon merolae (Cm) has been shown to have a simpler spliceosome. The goal of this study was to characterize the Cm spliceosome beginning with the question of how large it is. To measure the size of the Cm spliceosome I used glycerol gradient centrifugation and assembly gels to study the assembly pathways. Lastly an attempt was made to study the components of Cm spliceosome by developing an assay in yeast (Saccharomyces cerevisiae) where small molecule inhibitors were used to stall the spliceososme, which could then be purified and its composition studied. --Leaf ii.The original print copy of this thesis may be available here: http://wizard.unbc.ca/record=b197654
Laughing with an Iranian American Woman: Firoozeh Dumas\u27s Memoirs and the (Cross-) Cultural Work of Humor
No full textThis essay critically analyzes Firoozeh Dumas\u27s humorous memoirs and situates them in the multiple contexts of post-9/11 Muslim American responses to Islamophobia, women\u27s humor, and Iranian American women\u27s life writing. Drawing on philosophical, feminist, ethnic, and contemporary scientific theories of humor and the methods of literary criticism, the author argues that Dumas employs the beneficial and inclusive (not malign and exclusive) positive mode of humorous personal storytelling to build connection through laughter via the emotional and cognitive shifts structurally central to humor. Dumas addresses multiple audiences and engages in important (cross-) cultural work in a particularly fraught political and cultural climate of anti-Muslim sentiment and tense Iran-U.S. relations
Alexithymia, Posttraumatic Growth, and Life Contentment among Cardiac Sufferers
No full textBackground: Cardiovascular diseases are a common and increasing number of deaths in developing and developed countries. Heart diseases are considered chronic and affect blood flow that leads to a number of psychological issues. Cardiac issues cause a major disturbance in the quality of life of the patient.
Objective: To find out the relationship among alexithymia, posttraumatic growth, and life satisfaction among cardiac sufferers at DHQ Teaching Hospital and Siddique Sadiq Memorial Trust Hospital Gujranwala (Punjab; Pakistan).
Study type, settings & duration: A cross sectional study was conducted DHQ Teaching Hospital and Siddique Sadiq Memorial Trust Hospital, Gujranwala from February to August 2020.
Methodology: One hundred patients of heart attack from both genders aged 21-60 years. Toronto alexithymia scale (TAS-20), Posttraumatic growth inventory (PGI), and Satisfaction with life scale was used to collect data from the heart attack patients.
Results: The results of this study revealed that alexithymia including three sub-factors i.e. difficulty in identifying feelings, difficulty in describing feelings, and externally oriented thinking is significantly negatively correlated with life satisfaction while posttraumatic growth i.e. new possibilities and appreciations of life significant positive correlated with life satisfaction.
Conclusion: It was concluded that alexithymia has negative association with the satisfaction of life while posttraumatic growth is positively correlated with life satisfaction
Ageing ovaries and endometrium in PCOS
No full textObjective: to measure the outcome of age on ovarian and uterine morphology in women with primary infertility due to polycystic ovarian syndrome (PCOS) Materials and Methods: It was an observational cross sectional study. Two hundred primary infertile women with PCOs were subdivided into age groups (years) 20-30 (group I) and 31- 40 (group II). The ovarian volume (OV), follicles count (FC) and size (FS), uterine area (UA) and endometrial thickness (Endo) were determined by trans- abdominal (TAS) and trans -vaginal scan (TVS) using the ultrasound machine. Unpaired t-test was applied to evaluate the result Results: Comparison between group I and group II was made to evaluate the outcome. A significant raise was noted in the uterine morphology of group II. The UA was 89.99±5.83 v/s 119.0±23.33 (0.001) and endometrial thickness was 0.48±0.11 v/s 0.59±0.13 (0.001). A significant decline was noted in the ovarian morphology of group II; the OV (TAS) was 15.36± 2.56 v/s 10.57±12 (0.001) and TVS showed 15.74±2.23 v/s 10.37±1.08 (0.001). The FC was 14.05±1.56 v/s 12.47±0.89 (0.022) and FS was 9.45±7.98 v/s 4.33±5.88 (0.00). Conclusion: The OV, FC and FS (ovarian morphology) variables decreases in the elder infertile group with PCOs but the uterine morphology variables showed an increase in area with thickening of endometrium in the elder group
Colonizing Kashmir: state-building under Indian occupation Colonizing Kashmir: state-building under Indian occupation , by Hafsa Kanjwal, Stanford, Stanford University Press, 2023, xiii + 366 pp., $32, ISBN 978-1-5036-3603-3
No full textKashmiri life is expendable for the Indian state. While the love for the land is close to national imaginaries, the people have been subjected to decades of abuse and violence, and infringement of their basic human rights. In this book, Hafsa Kanjwal delves into the history of Kashmir, tracing the role of two pivotal political figures – Sheikh Abdullah (1947–1953) and Bakshi Ghulam Mohammad (1953–1963) – and their relationship with the Indian project of state-building in Kashmir. The author characterizes this as the ‘politics of life’ (9), where the Indian government and client regimes in Kashmir have normalized occupation with the propagation of ‘development, empowerment and progress’ along with bureaucratic integration and the forging of affective intimate relationships with the people of the state. However, the politics of life and appeals to emotions did not mean that there was an absence of coercive measures used by the Indian state to shape conforming and confronting subjectivities
Association of NOTCH4 Gene Polymorphism with the Susceptibility to Psoriasis Vulgaris in Pakistan
No full textBackground: Psoriasis Vulgaris (PsV) is one of the most severe chronic, immune mediated skin diseases. The Notch signaling pathway, a key regulator for epidermal renewal, contributes in differentiation, proliferation and survival of keratinocytes. Alterations in the NOTCH4 gene disrupts Notch pathway. The current study aimed to find out the association of NOTCH4 gene polymorphism(s) in Pakistani psoriatic patients.
Methods: A case control study, 390 DNA samples (190 samples of Psoriasis Vulgaris and 200 healthy control individuals), from January-December 2019, were selected from Rawalpindi Leprosy Hospital and healthy population, respectively. For amplification of (rs387071) SNP of NOTCH4 gene, lab standard protocols for T-ARMS-PCR were followed. Frequencies of genotype and allele were calculated by using Hardy Weinberg theorem. Data were analyzed by using SPSS and p-value ≤0.05 was considered statistically significant.
Results: The mean age of patients was 34.6±14 while among control subjects it was 32.8±10.0. In cases, genotype homozygous A/A119 (62.6%) was more prevalent, followed by heterozygous A/G171 (90%) while homozygous G/G19 (10%) was the least prevalent between cases and controls. Allele A frequency in diseased subjects was 0.76 while, for controls it was 0.78. In addition, allele G frequency in patients and controls was 0.24 and 0.22 respectively. Based on Hardy Weinberg equilibrium, no association of (rs387071) NOTCH4 gene with psoriasis cases was found.
Conclusion: NOTCH4 gene (rs387071) polymorphism was not significantly associated with patients of psoriasis Vulgaris in Pakistan. Larger studies are required to establish ethnic-specific markers for psoriasis in Pakistani population.
Keywords: Psoriasis Vulgaris; PCR; NOTCH4; Polymorphism
سلینگ اور اردو سلینگ: چند مباحث
No full textThis paper is a depiction of a new research topic the scholar takes the book of Dr Rauf parekh or Urdu slang, who is renowned Urdu scholar and editor of Urdu dictionary and his debate with another respected linguist.Dr parekh does not agree to accept the slang as informal language and excluded abusive language from his dictionary .Dr AttashDurrani opinion that Urdu there's no slang in its vast language areas .Often the words like slang are depicted as public, local Jargon, specific Bazar abusive, laborers language. Dr Parikh published his book as first urdu slang dictionary. Dr attash to reflected that he gave up a joint venture of editing Urdu slang with Dr sabirkaluravi both stated that there are no slang words spoken in Urdu rather one .they say that when slang is used in literature and thus entered in dictionaries ,is no means remains slang rather referred. The scholars shows the research to get more confident and specific strong results, after a deep analysis of the words entries labelled as slang .Both the linguists did not use term slanguage.' so it is necessary to did out the actuals
Association of NOTCH4 Gene Polymorphism with the Susceptibility to Psoriasis Vulgaris in Pakistan
No full textBackground: Psoriasis Vulgaris (PsV) is one of the most severe chronic, immune mediated skin diseases. The Notch signaling pathway, a key regulator for epidermal renewal, contributes in differentiation, proliferation and survival of keratinocytes. Alterations in the NOTCH4 gene disrupts Notch pathway. The current study aimed to find out the association of NOTCH4 gene polymorphism(s) in Pakistani psoriatic patients.
Methods: A case control study, 390 DNA samples (190 samples of Psoriasis Vulgaris and 200 healthy control individuals), from January-December 2019, were selected from Rawalpindi Leprosy Hospital and healthy population, respectively. For amplification of (rs387071) SNP of NOTCH4 gene, lab standard protocols for T-ARMS-PCR were followed. Frequencies of genotype and allele were calculated by using Hardy Weinberg theorem. Data were analyzed by using SPSS and p-value ≤0.05 was considered statistically significant.
Results: The mean age of patients was 34.6±14 while among control subjects it was 32.8±10.0. In cases, genotype homozygous A/A119 (62.6%) was more prevalent, followed by heterozygous A/G171 (90%) while homozygous G/G19 (10%) was the least prevalent between cases and controls. Allele A frequency in diseased subjects was 0.76 while, for controls it was 0.78. In addition, allele G frequency in patients and controls was 0.24 and 0.22 respectively. Based on Hardy Weinberg equilibrium, no association of (rs387071) NOTCH4 gene with psoriasis cases was found.
Conclusion: NOTCH4 gene (rs387071) polymorphism was not significantly associated with patients of psoriasis Vulgaris in Pakistan. Larger studies are required to establish ethnic-specific markers for psoriasis in Pakistani population.
Keywords: Psoriasis Vulgaris; PCR; NOTCH4; Polymorphism
