3,734 research outputs found
EEG-based biomarkers predict individual differences in TMS-induced entrainment of intrinsic brain rhythms
Full text linkBackground: Entrainment (increase) and modulation (shift) of intrinsic brain oscillations via rhythmic-TMS (rh-TMS) enables to either increase the amplitude of the individual peak oscillatory frequency, or experimentally slowing/accelerating this intrinsic peak oscillatory frequency by slightly shifting it. Both entrainment, and modulation of brain oscillations can lead to different measurable perceptual and cognitive changes. However, there are noticeable between-participant differences in such experimental entrainment outcomes. Objective/hypothesis: The current study aimed at explaining these inter-individual differences in entrainment/frequency shift success. Here we hypothesize that the width and the height of the Arnold tongue, i.e., the frequency offsets that can still lead to oscillatory change, can be individually modelled via resting-state neural markers, and may explain and predict efficacy and limitation of successful rhythmic-TMS (rh-TMS) manipulation. Methods: Spectral decomposition of resting-state data was used to extract the spectral curve of alpha activity, serving as a proxy of an individual Arnold tongue. These parameters were then used as predictors of the rh-TMS outcome, when increasing alpha-amplitude (i.e., applying pulse train tuned to the individual alpha frequency, IAF), or modulating the alpha-frequency (i.e., making alpha faster or slower by stimulating at IAF±1Hz frequencies). Results: Our results showed that the height of the at-rest alpha curve predicted how well the entrainment increased the intrinsic oscillatory peak frequency, with a higher at-rest spectral curve negatively predicting amplitude-enhancement during entrainment selectively during IAF-stimulation. In contrast, the wider the resting-state alpha curve, the higher the modulation effects aiming to shift the intrinsic frequency towards faster or slower rhythms. Conclusion: These results not only offer a theoretical and experimental model for explaining the variance across different rh-TMS studies reporting heterogenous rh-TMS outcomes, but also introduce a potential biomarker and corresponding evaluative tool to develop most optimal and personalized rh-TMS protocols, both in research and clinical applications
No effect of cold pressor test-induced arousal on attentional benefits and costs in an endogenous spatial orienting paradigm
No full textPrevious studies have shown that arousal can influence hemispatial bias, suggesting that changes in arousal affect the neural networks involved in spatial attention control. The goal of the present study was to measure the effects of increased arousal on endogenous attentional orienting. We used a Spatial Orienting Paradigm to quantify attentional benefits and costs as measures of attentional orienting and re-orienting responses and exposed participants (N = 25; Experiment 1) to a bilateral feet Cold Pressor Test (CPT) to manipulate arousal. Increases in subjective distress ratings and blood pressure confirmed the effect of CPT on arousal. Although no overall effects of CPT on reaction times in the Spatial Orienting Paradigm were detected, an exploratory analysis of sex-specific effects revealed a left-lateralised decrease in benefits and increase in costs after CPT exposure in the male subsample (N = 11). To confirm these preliminary results, we repeated the experiment in a larger sample (N = 29, all male), but found no effect of CPT on orienting, with moderate to strong evidence in favour of a model excluding all (interaction) effects of CPT exposure (all BFIncl <0.3). Instead, our replicated results indicate that voluntary orienting is unaffected by CPT-induced increases of arousal. In the light of previous studies, and keeping in mind the interpretative challenges of null results, we discuss how and why our findings may be specific to endogenous as opposed to exogenous orienting and how arousal could possibly lead to the previously established effects on visuospatial bias without simultaneously affecting orienting and the underlying attention control networks.</p
Letter from Alexander T. Vogelsang to Mr. Snyder regarding the Havasupai reservation with draft of proposed bill
No full textLetter from Alexander Vogelsang to Homer P. Snyder regarding land allocation for the Havasupai Tribe
sj-docx-1-eeg-10.1177_15500594221128713 - Supplemental material for Abnormal Cross Frequency Coupling of Brain Electroencephalographic Oscillations Related to Visual Oddball Task in Parkinson's Disease with Mild Cognitive Impairment
No full textSupplemental material, sj-docx-1-eeg-10.1177_15500594221128713 for Abnormal Cross Frequency Coupling of Brain Electroencephalographic Oscillations Related to Visual Oddball Task in Parkinson's Disease with Mild Cognitive Impairment by Zübeyir Bayraktaroğlu, Tuba Aktürk, Görsev Yener, Tom A. de Graaf, Lütfü Hanoğlu, Ebru Yıldırım, Duygu Hünerli Gündüz, İlayda Kıyı, Alexander T. Sack, Claudio Babiloni and Bahar Güntekin in Clinical EEG and Neuroscience</p
The poetical works of Alexander Pope, esq., to which is prefixed the life of the author,
No full textIncludes his translations of Homer, and Parnell's translation of The battle of the frogs and mice (Batrachomyomachia) corrected by Pope.Added t.-p., engr.: The poetical works of Alexander Pope, esq. Including his translation of Homer.Mode of access: Internet
Einfluss von Antidepressiva auf die Zytokinproduktion depressiver Patienten in-vitro
Full text linkIn der Pathophysiologie der Depression könnte das Zusammenspiel von Immun- und Nervensystem eine zentrale Rolle spielen. In den Krankheitsepisoden zeigen depressive Patienten eine gesteigerte Produktion pro-inflammatorischer Zytokine wie z. B. Interleukin
(IL)-1β und dem Tumornekrosefaktor (TNF)-α. Es gibt nur begrenzte Informationen bezüglich der Effekte von Antidepressiva auf Zytokine. Die meisten Studien berichten nur über die Veränderungen einzelner Zytokine und keine hat bis jetzt über Effekte von Antidepressiva auf IL-22 berichtet.
Wir haben systematisch die Wirkung von drei Antidepressiva, nämlich Citalopram, Escitalopram und Mirtazapin auf die Sekretion der Zytokine IL-1β, IL-2, IL-4, IL-6, IL-17, IL-22 und TNF-α in einem Vollblutverfahren in-vitro untersucht. Als Immunstimulanzien wurden der gegen humanes CD3 gerichtete monoklonale Antikörper OKT3 und der gegen CD40 gerichtete monoklonale Antikörper 5C3 verwendet. Es zeigte sich, dass es unter
Citalopram zu einer erhöhten IL-1β, I-6, IL-22 und TNF-α-Produktion und unter Mirtazapin zu einer erhöhten Produktion von IL-1β, IL-22 und TNF-α gegenüber der Kontrollbedingung, in der keine Antidepressiva zugesetzt wurden, kam. Unter Escitalopram kam es zu einer gegenüber der Kontrollbedingung verringerten IL-17-Produktion. Der Einfluss der
Antidepressiva auf IL-2 und IL-4 war für alle drei Psychopharmaka nicht signifikant. Verglichen mit Escitalopram führte Citalopram zu höheren IL-1β-, IL-6-, IL-17- und IL-22-Konzentrationen und Mirtazapin führte zu einer höheren IL-1β-, IL-17-, IL-22- und TNF-α-Produktion. Möglicherweise besteht ein Bezug zwischen dem Profil der Zytokinproduktion eines Antidepressivums und seinen therapeutischen Effekten, Nebenwirkungen und seinem Rückfallrisiko. Zur Überprüfung dieser Hypothese sind jedoch in-vivo Studien notwendig.:1. Bibliografische Zusammenfassung 3
2. Abkürzungsverzeichnis 4
3. Einführung 6
3.1. Einleitung 6
3.2. Ziel der vorliegenden Arbeit und Fragestellung 10
3.3. Materialien und Methoden 11
3.4. Ergebnisse 14
3.4.1. Einfluss der Antidepressiva auf die Zytokinproduktion 14
3.4.2. Vergleich der Antidepressiva 16
3.5. Diskussion 17
4. Publikation 20
5. Zusammenfassung 35
6. Literaturverzeichnis 37
7. Anlagen 44
7.1. Erklärung über die eigenständige Abfassung der Arbeit 44
7.2. Publikationen 45
7.3. Danksagung 46The interplay between immune and nervous systems plays a pivotal role in the pathophysiology of depression. In depressive episodes, patients show increased production of pro-inflammatory cytokines such as interleukin (IL)-1β and tumor necrosis factor (TNF)-α. There is limited information on the effect of antidepressant drugs on cytokines, most studies report on a limited sample of cytokines and none have reported effects on IL-22. We systematically investigated the effect of three antidepressant drugs, citalopram, escitalopram and mirtazapine, on secretion of cytokines IL-1β, IL-2, IL-4, IL-6, IL-17, IL-22 and TNF-α in a whole blood assay in vitro, using murine anti-human CD3 monoclonal antibody OKT3, and 5C3 monoclonal antibody against CD40, to stimulate T
and B cells respectively.Citalopram increased production of IL-1β, IL-6, TNF-α and IL-22. Mirtazapine increased IL-1β, TNF-α and IL-22. Escitalopram decreased IL-17 levels. The influence of antidepressants on IL-2 and IL-4 levels was not significant for all three drugs. Compared to escitalopram, citalopram led to higher levels of IL-1β, IL-6, IL-17 and IL-22; and mirtazapine to higher levels of IL-1β, IL-17, IL-22 and TNF-α.
Mirtazapine and citalopram increased IL-22 production. The differing profile of cytokine production may relate to differences in therapeutic effects, risk of relapse and side effects.:1. Bibliografische Zusammenfassung 3
2. Abkürzungsverzeichnis 4
3. Einführung 6
3.1. Einleitung 6
3.2. Ziel der vorliegenden Arbeit und Fragestellung 10
3.3. Materialien und Methoden 11
3.4. Ergebnisse 14
3.4.1. Einfluss der Antidepressiva auf die Zytokinproduktion 14
3.4.2. Vergleich der Antidepressiva 16
3.5. Diskussion 17
4. Publikation 20
5. Zusammenfassung 35
6. Literaturverzeichnis 37
7. Anlagen 44
7.1. Erklärung über die eigenständige Abfassung der Arbeit 44
7.2. Publikationen 45
7.3. Danksagung 4
Heterogeneous and tissue-specific regulation of effector T cell responses by IFN-gamma during Plasmodium berghei ANKA infection.
Full text linkIFN-γ and T cells are both required for the development of experimental cerebral malaria during Plasmodium berghei ANKA infection. Surprisingly, however, the role of IFN-γ in shaping the effector CD4(+) and CD8(+) T cell response during this infection has not been examined in detail. To address this, we have compared the effector T cell responses in wild-type and IFN-γ(-/-) mice during P. berghei ANKA infection. The expansion of splenic CD4(+) and CD8(+) T cells during P. berghei ANKA infection was unaffected by the absence of IFN-γ, but the contraction phase of the T cell response was significantly attenuated. Splenic T cell activation and effector function were essentially normal in IFN-γ(-/-) mice; however, the migration to, and accumulation of, effector CD4(+) and CD8(+) T cells in the lung, liver, and brain was altered in IFN-γ(-/-) mice. Interestingly, activation and accumulation of T cells in various nonlymphoid organs was differently affected by lack of IFN-γ, suggesting that IFN-γ influences T cell effector function to varying levels in different anatomical locations. Importantly, control of splenic T cell numbers during P. berghei ANKA infection depended on active IFN-γ-dependent environmental signals--leading to T cell apoptosis--rather than upon intrinsic alterations in T cell programming. To our knowledge, this is the first study to fully investigate the role of IFN-γ in modulating T cell function during P. berghei ANKA infection and reveals that IFN-γ is required for efficient contraction of the pool of activated T cells
An introduction to clinical pharmaceutics / Alexander T. Florence.
No full textBook fair2012xiii, 179 pages:This textbook describes a variety of dosage forms and their clinical importance and use. The use and behaviour of dosage forms in different age groups and patient groups will also be considered along with recent developments such as personalised therapies and genomics. It contains relevant examples and clinical case studie
The default mode network and the working memory network are not anti-correlated during all phases of a working memory task.
Full text linkIntroductionThe default mode network and the working memory network are known to be anti-correlated during sustained cognitive processing, in a load-dependent manner. We hypothesized that functional connectivity among nodes of the two networks could be dynamically modulated by task phases across time.MethodsTo address the dynamic links between default mode network and the working memory network, we used a delayed visuo-spatial working memory paradigm, which allowed us to separate three different phases of working memory (encoding, maintenance, and retrieval), and analyzed the functional connectivity during each phase within and between the default mode network and the working memory network networks.ResultsWe found that the two networks are anti-correlated only during the maintenance phase of working memory, i.e. when attention is focused on a memorized stimulus in the absence of external input. Conversely, during the encoding and retrieval phases, when the external stimulation is present, the default mode network is positively coupled with the working memory network, suggesting the existence of a dynamically switching of functional connectivity between "task-positive" and "task-negative" brain networks.ConclusionsOur results demonstrate that the well-established dichotomy of the human brain (anti-correlated networks during rest and balanced activation-deactivation during cognition) has a more nuanced organization than previously thought and engages in different patterns of correlation and anti-correlation during specific sub-phases of a cognitive task. This nuanced organization reinforces the hypothesis of a direct involvement of the default mode network in cognitive functions, as represented by a dynamic rather than static interaction with specific task-positive networks, such as the working memory network
Odoardo Fialetti (1573-c.1638): the interrelation of Venetian art and anatomy, and his importance in England
No full textBolognese artist Odoardo Fialetti (1573 – c.1638) is a fascinating figure upon which curiously little work has been done. Though he is a rarely discussed pupil of Tintoretto, Fialetti’s oeuvre is vast (some 55 known paintings and approximately 450 prints) and incredibly diverse. His work encompasses religious subjects, portraits, books on drawing and sport, maps, and illustration for treatises on city defences, literary texts, and anatomy. His work was influential for several hundred years after his death, not only in Venice and northern Italy, but also in France where his designs were used as decoration on faïence produced at Nevers, and England, where his paintings were much admired at court. Fialetti’s close association with Sir Henry Wotton, and the careful copy of his drawing book made by Alexander Browne in the mid-seventeenth century, attest to his impact on the formation of an Italianate sensibility in the appreciation of the visual arts in Early Modern England. In the realm of science, Fialetti’s influence can be deduced from his drawings of curiously animated cadavers in detailed landscapes to those of future generations of anatomists and illustrators throughout Europe. Because of the diverse associations and projects throughout his career, the study of Fialetti is inherently interdisciplinary, encompassing the history of art, history of science and history of the Venetian book trade, as well as crossing geographical boundaries in linking Venetian art and English tastes of the late renaissance and early baroque. Through examination of his extant oeuvre, as well as discussion of lost work, I aim to recognise Fialetti’s status as an artist responding to contemporary artistic debates (disegno versus colorito), a changing cultural climate and the burgeoning importance of the printed medium
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