58 research outputs found
From a Problem to the Problem System
No full textThis case study brings to the fore designer‘s experience and challenges of intervening in a complex social system. The presentation refers to the “Need Assessment Study of Occupational and Health Hazards Faced by Desludging Workers in a City in India.” This study marked the first milestone towards understanding the safety concerns of sanitation workers in the larger context of safe sanitation practices in small and medium towns in India, where faecal sludge management is emerging as a viable way forward under the larger system of faecal sludge management. This paper focuses on the research methodology and processes used in the study in order to better understand how these might be replicated or used in other similar contexts. In particular, the presentation shall discuss the interrelationships at length to understand the dynamic, multicausal, and unpredictable nature of the complex social system as found during the study. Conducted in two Indian cities, the de-sludging operators offer cleaning services to households, establishments, and industries. (Mamta Gautam et al,19).
This presentation discusses the research design, its implementation, and findings leading to systemic design. This is being discussed from the perspective of the author as the lead design researcher for the project commissioned by IIHS
FDI Spillovers, Innovation and the Role of Industrial Clusters: Evidence from Innovative Indian Manufacturing Firms
No full text© 2025, Elsevier B.V. The attached document (embargoed until 08/09/2026) is an author produced version of a paper published in Economic Modelling uploaded in accordance with the publisher’s self-archiving policy. The final published version (version of record) is available online at the link. Some minor differences between this version and the final published version may remain. We suggest you refer to the final published version should you wish to cite from it
The dynamics of Australian commodity prices
No full textThe study uses Johansen’s (1988, 1991) cointegration technique and vector error correction model to understand the dynamic interactions between Australian commodity prices and other fundamental macroeconomic variables. The author has been formulated the econometric models by using seasonally adjusted monthly time series from January 2000 to December 2015. The study shows that the real interest rate (rr), real exchange rate (rer) and the industrial production (ip) have an adverse effect on Australian real commodity price (rci). Moreover, the model of this study shows that all the variables are helping to restore the divergence from the long-run equilibrium in commodity prices of Australi
Expanding horizons in the treatment of mantle cell lymphoma: Ibrutinib a novel BTK-targeting inhibitor
No full textMantle cell lymphoma (MCL) is a non-Hodgkin lymphoma characterized by involvement of the lymph nodes, spleen, blood, and bone marrow with short remission duration to standard therapies and a median overall survival of 4–5 years. Small molecule inhibitors targeting dysregulated pathways (MAPK/ERK, PI3K/PKB/mTOR, JAK/STAT) have significantly improved clinical outcomes in cancer patients. Recently Bruton’s tyrosine kinase (BTK), a crucial terminal kinase enzyme in the B-cell antigen receptor (BCR) signaling pathway, has emerged as an attractive target for therapeutic intervention in human malignancies and autoimmune disorders. Ibrutinib, a novel first-in-human BTK-inhibitor, has demonstrated clinical effectiveness and tolerability in clinical trials, recently been approved by FDA in the treatment of MCL.
Dapagliflozin: a new adjunct in the treatment of Type 2 diabetes mellitus
No full textDiabetes mellitus (DM) Type 2 is a metabolic disorder that is characterized by high blood glucose in the context of insulin resistance and relative insulin deficiency. The classic symptoms are excess thirst, frequent urination, and constant hunger. Management of Type 2 diabetes focuses on lifestyle interventions, lowering other cardiovascular risk factors, and maintaining blood glucose levels in the normal range. There are several classes of anti-diabetic medications available and these include sulfonylureas, nonsulfonylurea secretagogues, alpha glucosidase inhibitors, thiazolidinediones, glucagon-like peptide-1 analog, and dipeptidyl peptidase-4 inhibitors. Recently, dapagliflozin (Farxiga™), a sodium-glucose cotransporter 2 inhibitor has been approved by Food and Drug Administration as an adjunct to diet and exercises to improve glycemic control in adults with Type 2 DM
Study of thickness and uniformity of oxide passivation with DI-O3 on silicon substrate for electronic and photonic applications
No full textImpact of patient outreach methods on human papillomavirus (HPV) vaccination
No full textPurpose of the Project: The purpose of this quantitative, quality improvement (QI) project was to improve initiation rates of human papillomavirus (HPV) vaccination among children ages 9 through 13 at a federally qualified health center (FQHC) in Hudson County.
Methodology: Two educational seminars and electronic health record (EHR) facilitated automated voice and patient portal messages were implemented over a 2-week period with a total of two attempts recommending the HPV vaccine. A 2-month retrospective and prospective analysis was conducted to evaluate the impact of the interventions on HPV vaccination.
Results: The total sample size in the preintervention (September - October 2021) and postintervention (September - October 2022) cohorts were 236 and 520, respectively. The total number of first dose HPV vaccine recipients in the pre- and postintervention cohorts were 66 and 115, respectively. There were insignificant statistical results of the first dose HPV vaccination in the pre- and postintervention, X 2 = 3.05 (1), p = 0.08. In the preintervention, 22.4% (n = 35) of 9-year-olds did not receive the first dose of HPV vaccine compared to 53.2% (n = 83) in the postintervention. Thus, statistical significance was noted only for age 9 compared to all other age groups (X 2 = .5.25 (1), p = .022).
Implications for Practice: Based on the findings in this study, future recommendations include implementation of EHR-facilitated interventions to reduce missed opportunities, as well as educational campaigns focused on strong provider recommendation and vaccine hesitancy to improve first, second, and/or third dose of HPV vaccination.D.N.P.Includes bibliographical reference
The Portrayal of Girl Child in Ruskin Bond’s The Blue Umbrella
No full textRuskin Bond, Indian author of British decent, was born on 19 May 1935 at Kasauli, Himachal Pradesh. He was raised at Jamnagar (Gujarat), Shimla and Dehradun. He is a well-known Indian writer in English. He has written more than hundred short stories, six novels, three collection of verse and over thirty books for children. He is considered to be an icon among Indian writers and children’s author and a top novelist. He received Sahitya Academy award for his book; Our Trees Still Grow at Dehra in 1992, and was honored with Padam Shree in 1999 for his lifetime contribution to Indian literature in English. He was awarded with Padam Bhusham in 2014. He has been writing for the last fifty years in different genre of literature. His stories and novels got wide publicity worldwide in India. Various directors produced films on his novels. He was also appreciated by various prizes and awards at national level. In 2005, the Bollywood director Vishal Bhardwaj made a film based on his popular novel for children, The Blue Umbrella. The movie won the National Award for best Children’s film. It is a fine specimen published in 1992. This novella has also been filmed in 2007. It is set in a small village of Garhwal, where a little highland girl, Binya lives. She trades her lucky leopard claw pendent with a picknicker lady for a pretty blue umbrella
A Proposal for Exhaustive Search on Desktop Data
No full textAbstractData on one's personal computer (PC) is continue to increase day by day and it has made need of managing personal desktop data as an active area of research. Managing desktop data includes an efficient way of searching and retrieving desired data and information from it. Several search engines and search tools are developed to provide search on the desktop data. In this paper, we present a solution for providing exhaustive search on one's heterogeneous desktop data
Standardisation and Validation of Acute and Chronic Administration Ketamine at Different Doses to Produce Psychosis Like Behavioural Changes in Mice
No full textPsychosis is a complex mental illness, characterised by positive, negative and cognitive symptoms. NMDA receptor
antagonists have been established to induce behavioural as well as biochemical changes in rodents similar to psychotic
patients. The aim of the present study was to investigate the effective dose and treatment period of ketamine to induce
some behavioural changes. The results suggest that acute treatment of ketamine (50 and 100 mg/kg, i.p.) induced
hyperlocomotor activity and reduced step down latency time in passive avoidance test, whereas in effective in forced swim
test. Further, with the chronic administration of ketamine (50 and 100 mg/kg, i.p.) effective to produced hyperlocomotor
activity, reduced the step down latency time in passive avoidance test and enhanced the immobility duration in forced swim
test. Moreover, these behavioural changes persisted for 7 days after the treatment period. Thus, our findings suggest that
the chronic administration of Ketamine (50 and 100 mg/kg, i.p.) potential to produce behavioural changes, would serve as
an effective tool to screen antipsychotic drugs.</jats:p
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