1,204 research outputs found
Site and size of lesion and psychosurgical outcome in obsessive-compulsive disorder: A magnetic resonance imaging study
No full textSachdev, Perminder; Hay, Phillip
Arterial stiffness, the brain and cognition: A systematic review
No full textAbstract not availableJoel Singer, Julian N. Trollor, Bernhard T. Baune, Perminder S. Sachdev, Evelyn Smit
Is the incidence of dementia declining?
Full text linkAction on preventative health could lower the risk of dementia for future generations, argues this report.
Executive summary
The world-wide projections of the prevalence of dementia in the coming decades have been a source of great concern to health systems and societies around the world. The World Alzheimer Report 2010 estimated that there were 36 million people with dementia in 2010, with an expected doubling every 20 years to nearly 115 million in 2050. These sobering figures are based on assumptions that the age-adjusted prevalence of dementia would remain constant and the population would continue to age at the current rate.
The assumption that the incidence of dementia will remain stable is now being put into question. There is emerging evidence to suggest that the incidence of dementia in older individuals may be declining. It appears that this change may be recent and has possibly occurred only in the last one to two decades. It may also be restricted so far to high income countries, although data from low and middle income countries are lacking.
The reasons for this change are not understood, but education, more stimulating environments and better control of vascular risk factors may have contributed. The data are still preliminary and more studies are needed to establish the extent of this change and understand its causes. It should be noted that the decline is not large enough to offset the increase in prevalence of dementia due to the ageing of the population and therefore investment and efforts to develop better treatments and care for people with dementia need to continue.
The fact that dementia rates are malleable is an encouraging finding but the reduction cannot be taken for granted as gains in population health can easily be lost if societies do not remain vigilant and continually proactive. These preliminary findings provide a strong argument for large scale Government investment in dementia-prevention strategies, which should start from early life
Supplemental – Supplemental material for The psychological health of 207 near-centenarians (95–99) and centenarians from the Sydney Centenarian Study
No full textSupplemental material, Supplemental for The psychological health of 207 near-centenarians (95–99) and centenarians from the Sydney Centenarian Study by Adrian Cheng, Yvonne Leung, John D Crawford, Fleur Harrison, Perminder Sachdev and Henry Brodaty in Australian & New Zealand Journal of Psychiatry</p
sj-docx-2-his-10.1177_11786329241232254 – Supplemental material for The Integrated Atlas of Dementia Care in the Australian Capital Territory: A Collective Case Study of Local Service Provision
No full textSupplemental material, sj-docx-2-his-10.1177_11786329241232254 for The Integrated Atlas of Dementia Care in the Australian Capital Territory: A Collective Case Study of Local Service Provision by Hossein Tabatabaei-Jafari, Mary Anne Furst, Nasser Bagheri, Nathan M. D’Cunha, Kasia Bail, Perminder S. Sachdev and Luis Salvador-Carulla in Health Services Insights</p
sj-docx-1-his-10.1177_11786329241232254 – Supplemental material for The Integrated Atlas of Dementia Care in the Australian Capital Territory: A Collective Case Study of Local Service Provision
No full textSupplemental material, sj-docx-1-his-10.1177_11786329241232254 for The Integrated Atlas of Dementia Care in the Australian Capital Territory: A Collective Case Study of Local Service Provision by Hossein Tabatabaei-Jafari, Mary Anne Furst, Nasser Bagheri, Nathan M. D’Cunha, Kasia Bail, Perminder S. Sachdev and Luis Salvador-Carulla in Health Services Insights</p
An inverse relationship between serum macrophage inhibitory cytokine-1 levels and brain white matter integrity in community-dwelling older individuals
No full textAbstract not availableJiyang Jiang, Julian N. Trollor, David A. Brown, John D. Crawford, Anbupalam Thalamuthu, Evelyn Smith, Samuel N. Breit, Tao Liu, Henry Brodaty, Bernhard T. Baune, Perminder S. Sachdev, Wei We
Non-pharmacological interventions in secondary schizophrenia
No full textSchizophrenia may not be a single disease, but the result of a diverse set of related conditions. Modern neuroscience is beginning to reveal some of the genetic and environmental underpinnings of schizophrenia; however, an approach less well travelled is to examine the medical disorders that produce symptoms resembling schizophrenia. This book is the first major attempt to bring together the diseases that produce what has been termed 'secondary schizophrenia'. International experts from diverse backgrounds ask the questions: does this medical disorder, or drug, or condition cause psychosis? If yes, does it resemble schizophrenia? What mechanisms form the basis of this relationship? What implications does this understanding have for aetiology and treatment? The answers are a feast for clinicians and researchers of psychosis and schizophrenia. They mark the next step in trying to meet the most important challenge to modern neuroscience – understanding and conquering this most mysterious of human diseases
sj-docx-2-asm-10.1177_10731911221127902 – Supplemental material for Measuring Empathy Across the Adult Lifespan: A Comparison of Three Assessment Types
No full textSupplemental material, sj-docx-2-asm-10.1177_10731911221127902 for Measuring Empathy Across the Adult Lifespan: A Comparison of Three Assessment Types by Sarah A. Grainger, Kate T. McKay, Julia C. Riches, Russell J. Chander, Rhiagh Cleary, Karen A. Mather, Nicole A. Kochan, Perminder S. Sachdev and Julie D. Henry in Assessment</p
The relationship between inflammatory markers and voxel-based gray matter volumes in nondemented older adults
No full textAbstract not availableHaobo Zhang, Perminder S. Sachdev, Wei Wen, John D. Crawford, Henry Brodaty, Bernard T. Baune, Nicole A. Kochan, Melissa J. Slavin, Simone Reppermund, Kristan Kang, Julian N. Trollo
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