1,721,112 research outputs found
Special Section on IEEE MeMeA 2021
No full textThe 16th edition of the IEEE International Symposium on Medical Measurements and Applications was held on June 23-25, 2021. The Symposium, whose first edition was held in 2006 in Benevento, Italy, has become an annual meeting for researchers from academia and industry working in the field of medical measurements and instrumentation. The Symposium offers them the opportunity to work together to design and develop feasible and effective measurement solutions and instrumentation for data processing, medical diagnosis and patient healthcare
A sensitivity analysis of laser thermotherapy efficacy in lung cancer treatment to the temperature dependence of thermal properties
Full text linkLaser interstitial thermotherapy has shown potential in the treatment of inoperable lung cancers, which make up 70-80 % of all cases, thanks to the possibility of real-time ultrasound guidance, a fine introducer needle, and faster recovery after the procedure. To plan a laser ablation session through numerical modeling, the sensitivity analysis of the input parameters is necessary since simplifying the influential parameters could lead to a different treatment outcome.The purpose of this study is to determine the sensitivity of laser-induced ablated volume, an indicator of therapy efficacy, with regard to the temperature dependence of thermal properties in the clinical power ranges (i.e., between 2 W and 5 W at the wavelength of 1064 nm) for lung tissue. According to the results, the difference between ablated volumes derived from constant and temperature-dependent thermal properties grows with increasing power, reaching 17.5% and 60.3% under ex vivo and in vivo conditions at 5 W, respectively. As the blood perfusion rate strongly affects the thermal effects in tissue, the temperature dependency of this parameter cannot be ignored. The assumption of constant thermal properties is valid for ex vivo planning by acceptable error when the laser power is set at a low level, e.g., ~ 2% at 2 W and ~ 6% at 3 W.Clinical Relevance - The methods and results of this study set the basis for defining the accurate pre-planning of laser-induced thermotherapy of lung cancer
Can gold nanoparticles improve delivery performance of polymeric drug delivery systems?
Full text linkDuring the recent developments in nanomedicine, gold nanoparticles (Au NPs) have emerged as interesting tools
in the field of drug-delivery systems (DDS) due to their low toxicity, stability, easy synthesis and reproducibility [1].
Au NPs are able to link therapeutic molecules on their surface by covalent or noncovalent bonding or by a previous
functionalization of Au NPs and release the drug only in a specific site without damaging the healthy tissue [2].
Moreover, the small size of gold NPs allows their accumulation in sites of tumor and inflammation and exhibit
fast cell uptake using mechanisms different from those typical of small molecules [3]. Their optical property is
characterized by surface plasmon resonance (SPR), by which incident light is converted into heat, which makes
them very useful in promoting photothermal drug release [4]. The main drawback resides in the fact that after their
administration, if not confined, they escape through the circulatory torrent without reaching the target site and so
losing their efficacy. For this purpose, hybrid materials formed by the loading of Au NPs inside polymer networks
are studied to improve local drug delivery. In this case, the easy injection and confinement of the hydrogel in the
site of injury represent the main advantages together with local release of both small and large molecules in response
to thermal stimuli [5]
A high sensitivity fiber optic macro-bend based gas flow rate transducer for low flow rates: Theory, working principle, and static calibration
No full textDesign of fiber optic applicators for laser interstitial thermotherapy: Theoretical evaluation of thermal outcomes
No full textMechanical ventilation with heated humidifiers: measurements of condensed water mass within the breathing circuit according to ventilatory settings.
No full textPerformances of heated wire humidifiers during adult mechanical ventilation: Estimation of the amount of condensation
No full text- …
