1,721,267 research outputs found

    D-Serine metabolism: New insights into the modulation of d-amino acid oxidase activity

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    Over the years, accumulating evidence has indicated that d-serine represents the main endogenous ligand of NMDA (N-methyl-d-aspartate) receptors. In the brain, the concentration of d-serine stored in cells is defined by the activity of two enzymes: serine racemase (responsible for both the synthesis and degradation) and d-amino acid oxidase (which catalyses d-serine degradation). The present review is focused on human damino acid oxidase, discussing the mechanisms involved in modulating enzyme activity and stability, with the aim to substantiate the pivotal role of d-amino acid oxidase in brain d-serine metabolism. © 2013 Biochemical Society

    Le politiche del lavoro nell'era digitale: indicazioni per l'Italia dall'evidenza comparata

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    The use of digital tools in the design and delivery of social policies is a topic of growing interest in public and scientific debate. An important part of this debate is devoted to active labour market policies (ALMPs). In Italy, digitalization can provide an opportunity to fill some historical gaps and overcome structural limitations of ALMPs, particularly within the framework of the investments envisaged by the National Recovery and Resilience Plan (NRRP). This article first aims to offer an empirical account of the actual tools and processes introduced in four cases of ALMPs’ digitalization in Europe, selected according to the degree of development of digital services and their multi-level governance: the Netherlands, Austria, Denmark and Flanders. This description illustrates the governance of ALMPs, and then focuses on the dimensions of employment assistance that are most affected by digitalization: access, diagnosis, and job matching. This exercise is then made relevant to Italian ALMPs, finalizing it to identify some policy directions for initiating a strategy for the digitalization of ALMPs in such country
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