3,638 research outputs found
sj-png-2-njn-10.1177_20571585241227583 - Supplemental material for Swedish nursing research: A bibliometric and content analysis revealing author and institute collaborations, impact, and topics
No full textSupplemental material, sj-png-2-njn-10.1177_20571585241227583 for Swedish nursing research: A bibliometric and content analysis revealing author and institute collaborations, impact, and topics by Christopher Holmberg in Nordic Journal of Nursing Research</p
SJ Sindu: 47th Annual ODU Literary Festival
No full textSJ Sindu is a Tamil diaspora author of two literary novels (Marriage of a Thousand Lies, which won the Publishing Triangle Edmund White Award; and Blue-Skinned Gods, which was an Indie Next Pick and a finalist for the Lambda Literary Award), two graphic novels (Shakti and the forthcoming Tall Water), and one collection of short stories (The Goth House Experiment). Sindu holds a PhD in English and Creative Writing from Florida State University and is a co-editor for Zero Street, a literary fiction series featuring LGBTQ+ authors through the University of Nebraska Press. Sindu is an assistant professor at Virginia Commonwealth University. More at sjsindu.com
sj-png-3-njn-10.1177_20571585241227583 - Supplemental material for Swedish nursing research: A bibliometric and content analysis revealing author and institute collaborations, impact, and topics
No full textSupplemental material, sj-png-3-njn-10.1177_20571585241227583 for Swedish nursing research: A bibliometric and content analysis revealing author and institute collaborations, impact, and topics by Christopher Holmberg in Nordic Journal of Nursing Research</p
sj-png-1-njn-10.1177_20571585241227583 - Supplemental material for Swedish nursing research: A bibliometric and content analysis revealing author and institute collaborations, impact, and topics
No full textSupplemental material, sj-png-1-njn-10.1177_20571585241227583 for Swedish nursing research: A bibliometric and content analysis revealing author and institute collaborations, impact, and topics by Christopher Holmberg in Nordic Journal of Nursing Research</p
Long-term follow-up of endurance and safety outcomes during enzyme replacement therapy for mucopolysaccharidosis VI: Final results of three clinical studies of recombinant human N-acetylgalactosamine 4-sulfatase
No full textCopyright © 2008 Elsevier Inc. All rights reserved.UnlabelledThe objective of this study was to evaluate the long-term clinical benefits and safety of recombinant human arylsulfatase B (rhASB) treatment of mucopolysaccharidosis type VI (MPS VI: Maroteaux-Lamy syndrome), a lysosomal storage disease. Fifty-six patients derived from 3 clinical studies were followed in open-label extension studies for a total period of 97-260 Weeks. All patients received weekly infusions of rhASB at 1 mg/kg. Efficacy was evaluated by (1) distance walked in a 12-minute walk test (12MWT) or 6-minute walk test (6MWT), (2) stairs climbed in the 3-minute stair climb (3MSC), and (3) reduction in urinary glycosaminoglycans (GAG). Safety was evaluated by compliance, adverse event (AE) reporting and adherence to treatment.ResultsA significant reduction in urinary GAG (71-79%) was sustained. For the 12MWT, subjects in Phase 2 showed improvement of 255+/-191 m (mean+/-SD) at Week 144; those in Phase 3 Extension demonstrated improvement from study baseline of 183+/-26 m (mean+/- SE) in the rhASB/rhASB group at Week 96 and from treatment baseline (Week 24) of 117+/-25 m in the placebo/rhASB group. The Phase 1/2 6MWT and the 3MSC from Phase 2 and 3 also showed sustained improvements through the final study measurements. Compliance was 98% overall. Only 560 of 4121 reported AEs (14%) were related to treatment with only 10 of 560 (2%) described as severe.ConclusionrhASB treatment up to 5 years results in sustained improvements in endurance and has an acceptable safety profile.Paul Harmatz, Roberto Giugliani, Ida Vanessa D. Schwartz, Nathalie Guffon, Elisa Leão Teles, M. Clara Sá Miranda, J. Edmond Wraith, Michael Beck, Laila Arash, Maurizio Scarpa, David Ketteridge, John J. Hopwood, Barbara Plecko, Robert Steiner, Chester B. Whitley, Paige Kaplan, Zi-Fan Yu, Stuart J. Swiedler, Celeste Decker and for the MPS VI Study Grouphttp://www.elsevier.com/wps/find/journaldescription.cws_home/622920/description#descriptio
sj-docx-1-mdm-10.1177_0272989X221097106 – Supplemental material for Trends in Author-Reported Cost-Effectiveness Thresholds in the United States from 1995 to 2018: Implications for Discount Rates
No full textSupplemental material, sj-docx-1-mdm-10.1177_0272989X221097106 for Trends in Author-Reported Cost-Effectiveness Thresholds in the United States from 1995 to 2018: Implications for Discount Rates by Ankur Pandya, Mike Paulden, Jinyi Zhu, Tara A. Lavelle and James Hammitt in Medical Decision Making</p
Design of bimetallic nanoparticles
No full textThis work was supported by Korean Research Foundation Grant(KRF-2003-003-D00087). The author(S.J.Cho) acknowledged the generous permission to use the synchortron radiation at the Pohang Accelerator Laboratory
Enzyme replacement therapy for mucopolysaccharidosis VI from 8 weeks of age - a sibling control study
No full textMucopolysaccharidosis type VI (MPS VI) is a progressive, multisystem disorder caused by a deficiency of the lysosomal enzyme N-acetylgalactosamine-4-sulphatase (ASB). Enzyme replacement therapy (ERT) has been shown to clinically benefit affected individuals greater than 6 years of age. This case control study of affected siblings assessed the safety, efficacy and benefits of ERT in children less than 5 years of age. Siblings, aged 8 weeks and 3.6 years, were treated weekly with 1 mg/kg recombinant human N-acetylgalactosamine-4-sulphatase (rhASB) with an end-point of 3.6 years. Clinical and biochemical parameters were monitored to assess the benefits of ERT. The treatment was well tolerated by both siblings. In the younger sibling, ERT was associated with the absence of the development of scoliosis and preserved joint movement, cardiac valves and facial morphology. The older sibling had a marked improvement in joint mobility and cardiac valve pathology and scoliosis slowed or stabilized. Corneal clouding and progressive skeletal changes were observed despite treatment. This study demonstrated a clear benefit of early initiation of ERT to slow or prevent the development of significant pathological changes of MPS VI. These results indicate that the earlier ERT is started, the greater the response.JJ McGill, AC Inwood, DJ Coman, ML Lipke, D de Lore, SJ Swiedler and JJ Hopwoo
A TCAD Simulation Study on the Short-circuit Performance of 650V P-pillar Offset Super-junction MOSFET
No full textThe limitation of Silicon based power MOSFET was broken by the super-junction (SJ) structure, which can provide lower specific on-resistance and higher breakdown voltage compared with the conventional power MOSFET structure. Multi-epitaxial and multi-ion-implant technology, as a mature manufacturing process of the SJ structure, has been widely used in the field of SJ-MOSFET. Therefore, this process is applied to construct the cell structure of 650V SJ-MOSFET in our study. Based on practical application, high current caused by unexpected short circuit will induce an increasing of the internal temperature of SJ-MOSFET, which leads to an irreversible damage in the SJ-MOSFET devices. However, the short-circuit robustness of SJ-MOSFET is still unstable, and the structure needs to be further improved. In our study, the electrical performance of a 650V SJ-MOSFET with offset P-pillar is theoretically investigated by means of technology computer aided design (TCAD) when the SJ-MOSFET is short circuited. The results clearly show that the optimized SJ-MOSFET can withstand the source-drain voltage of 400V for at least 10 μs in the case of the short-circuit. The thermal distribution and peak temperature of the cell structure of SJ-MOSFET are also simulated to assist in the analysis of the short circuit capable of the device. In addition, the hole current density distribution of two SJ-MOSFETs is considered to gain insight into the effect of P-pillar parameters on the short-circuit robustness. The result represents that the structure with offset P-pillar can effectively improve the short-circuit capability.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Bio-ElectronicsElectronic Components, Technology and Material
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