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Repolarization abnormalities in the newborn
Full text linkThe recognition of ventricular repolarization abnormalities
in the newborn carries several and significant implications, because it
calls attention to the possibility of dealing with an infant affected by the
long QT syndrome (LQTS). This article provides key elements for the
correct measurement of the QT interval in newborns and succinctly
reviews some aspects of the disease. It gives normative values on theQT
interval distribution in the firstmonth of life based on a prospective study
in more than 44,000 infants. It shows the probability, based on the QTc
observed in two recordings, to find disease-causing mutations. The data
indicate clearly that widespread electrocardiographic screening in the
newborn allowsearly identification ofmost, ifnot all, the infants affected
by LQTS with marked QT prolongation and thus of those at higher risk
for life-threatening arrhythmias and sudden death. Through the affected
infants, it becomes possible to identify the family members affected by
LQTS, including the ‘‘silent mutation carriers’’; our study shows that
disease-causing mutations are found in 51% of the family members.
Because early recognition leads to the implementation of effective
preventive strategies, it follows that electrocardiographic screening will
avoid preventable deaths either in the first year of life when they are
usually labeled as ‘‘sudden infant death syndrome’’ or later in life. The
case is made for medicolegal implicationswhenever neonatologists and
pediatricians fail to inform the parents of a newborn child of the prevalence
of LQTS (one in 2000), of the effectiveness of existing therapies,
and of the diagnosis with a simple electrocardiogram
Postnatal development of cardiac innervation and susceptibility to malignant arrhythmias in the dog.
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Current Strategies to Diminish the Impact of Cardiovascular Diseases in Women
Full text linkThe European Society of Cardiology (ESC) has recently promoted the "Women at Heart" program in order to organize initiatives targeted at promoting research and education in the field of cardiovascular diseases in women. Comparisons of the gender differences in specific disease and treatment trends across Europe are provided by analyzing data from the Euro Heart Surveys. A Policy Conference has been organized with the objective to summarize the state of the art from an European perspective, to identify the scientific gaps and to delineate the strategies for changing the misperception of cardiovascular diseases in women, improving risk stratification, diagnosis, and therapy from a gender perspective and increasing women representation in clinical trials. A Statement from the Policy Conference has been provided and published in the European Heart Journal. Synergic activities should be undertaken at European level with the support of national scientific societies, European institutions, national health care authorities, patients' associations, and foundations. The commitment of the Board of the ESC is that these initiatives contribute to increase the awareness across Europe that cardiovascular disease is the primary cause of death in women and to improve the knowledge of risk factors, presentation and treatment of cardiovascular diseases in women
Gender-specific prescription for cardiovascular diseases?
Full text linkThe interest of the scientific and medical community on the impact of cardiovascular diseases in women has significantly grown in the last few years. Cardiovascular disease is indeed the leading cause of death among both women and men, even if this unequivocal epidemiological observation had not been taken into the right consideration in the past. Although cardiovascular diseases are equally important in men and women, gender differences in the clinical manifestation and progression of the disease have been demonstrated. The understanding of these differences is of crucial importance for the improvement of the clinical management of cardiovascular diseases and for the development of possible new gender-specific diagnostic and therapeutic options
Development of cardiac innervation, ventricular fibrillation, and sudden infant death syndrome.
No full textEffects of beta-adrenergic blockade on dispersion of ventricular repolarization in newborn infants with prolonged QT interval.
No full textEffects of the potassium channel blocking agent ambasilide on ventricular arrhythmias induced by acute myocardial ischemia and sympathetic activation.
No full textComplex electrocardiographic findings ia a neonate with Long QT syndrome
No full textA case of long QT syndrome diagnosed in the early neonatal period is described. A full-term male baby was delivered by cesarean section at 38 weeks of gestation. The indication to cesarean section was sudden marked fetal bradycardia. At birth, he presented the following rhythm disorders: a) an ectopic atrial rhythm with T wave alternans, and b) atrioventricular conduction disorders. Sinus rhythm, with a prolonged QT interval and T wave alternans, was recovered soon after birth, before starting beta-blocker therapy. The family history was negative for the long QT syndrome: sudden unexpected death and/or syncopal episodes and cases of congenital deafness have not been reported. Molecular screening of the five long QT syndrome-related genes did not reveal the presence of any mutation. At 3 years of follow-up, the child is well and he did not present with symptoms or arrhythmias during this period
Are gender differences in QTc present at birth? MISNES Investigators. Multicenter Italian Study on Neonatal Electrocardiography and Sudden Infant Death Syndrome.
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