1,721,283 research outputs found
Conscientious objection in voluntary interruption of pregnancy. Between the marginalization of professionals and the return of illegal abortion
No full textLaw n.194/1978, while legalizing voluntary interruption of pregnancy (VIP) in Italy, introduced the clause of conscientious objection and, since then, many gynaecologists have invoked this right (the so-called pro-life who are opposed to the pro-choice). The hypothesis of this article is twofold and concerns the consequences of conscientious objection: on the one hand, pro-choice gynaecologists experience a form of marginality, in terms of workload, social status and power, resulting in their isolation and stigmatization; on the other, the difficulty of accessing VIP services can lead to the return of illegal abortion. The aim is to imagine what consequences this can bring to both users and professionals and to understand how it will be possible to guarantee a balance between the right to voluntary interruption of pregnancy and that to conscientious objection. In terms of methodology, a literature review, followed by a search for documentary material (Italian and foreign newspapers and websites discussing VIP and conscientious objection) was carried out; moreover, a long interview was conducted with a pro-choice gynaecologist, who represents a symbolic case in the Italian context. Some consideration about the future scenarios close the article
Un passo avanti, un passo indietro. I livelli essenziali delle prestazioni sociali per la non autosufficienza nella legge di Bilancio 2022
No full textThis article analyzes the introduction of essential levels of social services (LEPS) for longterm care (LTC) within the 2022 Budget Law. Despite growing population ageing, the Italian LTC system is characterized by persistent structural weaknesses concerning the coverage of care needs for dependent older persons. Against this background, the introduction of LEPS represents a first crucial step in terms of institutional change. However, such change could be undermined by the specific way through which the LEPS introduction and its funding have been regulated within the 2022 Budget Law
Clinical significance of pharmacokinetic interactions between antiepileptic and psychotropic drugs.
No full textAs antiepileptic drugs (AEDs) and psychotropic agents are increasingly used in combination, the possibility of pharmacokinetic interactions between these compounds is relatively common. Most pharmacokinetic interactions between AEDs and psychoactive drugs occur at a metabolic level, and usually involve changes in the activity of the cytochrome P450 mixed-function oxidases (CYP) involved in their biotransformation. As a consequence of CYP inhibition or induction, plasma concentrations of a given drug may reach toxic or sub-therapeutic levels, and dosage adjustments may be required to avoid adverse effects or clinical failure. Enzyme-inducing AEDs, such as carbamazepine (CBZ), phenytoin (PHT), and barbiturates, stimulate the oxidative biotransformation of many concurrently prescribed psychotropics. In particular, these AEDs may decrease the plasma concentrations of tricyclic antidepressants, many anti psychotics, including traditional compounds, i.e., haloperidol and chlorpromazine, and newer agents, i.e., clozapine, risperidone, olanzapine, quetiapine, and ziprasidone, and some benzodiazepines. Conversely, new AEDs appear to have a lower potential for interactions with all psychotropic drugs. While antipsychotics and anxiolytics do not significantly influence the pharmacokinetics of most AEDs, some newer antidepressants, such as viloxazine, fluoxetine, and fluvoxamine, may lead to higher serum levels of some AEDs, namely CBZ and PHT, through inhibition of CYP enzymes. No significant pharmacokinetic interactions have been documented between AEDs and Lithium. Information about CYP enzymes responsible for the biotransformation of individual agents and about the effects of these compounds on the activity of specific CYP enzymes may help in predicting and avoiding clinically significant interactions. Apart from careful clinical observation, serum level monitoring of AEDs and psychotropic drugs can be useful in determining the need for dosage adjustments, especially if there is any change in seizure control, or possible toxicity
The pharmacology and safety of paliperidone extended-release in the treatment of schizophrenia
No full textPaliperidone extended-release (ER) is a newly commercialised antipsychotic formulated using the principal active metabolite of risperidone, 9-hydroxyrisperidone. it has been developed as an osmotic control led-release oral delivery system that minimizes peak-trough fluctuations in plasma concentrations, allowing once-daily administration and theoretically leading to a decreased incidence of adverse effects. Available data from preregistration, multicenter, short-term, double-blind, placebo-controlled studies indicate that paliperidone ER, at dosages of 3 - 15 mg/day, is relatively safe and well tolerated in adult patients with schizophrenia. As with risperidone, paliperidone may cause extrapyramidal symptoms and hyperprolactinemia in a dose-dependent manner. Preliminary long-term studies (up to 52 weeks) appear to confirm the findings from short-term trials indicating a low liability for paliperidone ER to cause metabolic effects (i.e., weight gain, hyperglycaemia and lipid dysregulation). Safety data from elderly patients appear to be promising. Due to negligible hepatic biotransformation, paliperidone ER is unlikely to be involved in clinically significant metabolic drug-drug interactions
Il trattamento degli stati di agitazione psicotica con olanzapina iniettabile. Aspetti farmacologici e clinici
No full text
Elenco delle varietà di ribes, uva spina e josta
No full textElenco delle varietà di ribes, uva spina e josta
Ravenna, Spina e la tradizione pelasgica
No full textNel contributo si passano in rassegna le fonti relative all'origine pelasgica delle città di Spina e Ravenna riprendendo le principali teorie che hanno contribuito a chiarire il significato storico di tale tradizione
- …
