1,725,737 research outputs found
Occupational Therapy in Neurocritical Care: Use of Cycle Ergometry for Early Upper-Extremity Rehabilitation in a Critically Ill Stroke Patient
No full textAbstract
Date Presented 3/31/2017
Upper-extremity cycling is an intervention that facilitates bilateral integration and rhythmic, repetitive arm movement. This poster highlights its potential as a safe and effective therapy for critically ill stroke patients in the early recovery period.
Primary Author and Speaker: Sandra Deluzio
Additional Authors and Speakers: Isha Vora
Contributing Authors: Sowmya Kumble, Mona Bahouth</jats:p
Historical Remote Sensing Analysis of Dust Bowl Drought in Kansas: Corrected and Georeferenced 1936 Aerial Photographs
No full textThis dataset includes a collection of corrected and georeferenced overlapping first-generation aerial photographs from 1936, created to support the study "Historical Remote Sensing Analysis of Dust Bowl Drought in Kansas." The original images have been processed to correct distortions and aligned using georeferencing techniques, producing an accurate and seamless spatial representation of Hamilton County, Kansas.
The overlapping nature of the photographs allows for stereo interpretation and enhanced visual analysis, making it possible to extract terrain features and assess land surface conditions in greater detail. This dataset is particularly valuable for evaluating land use changes, land degradation and vegetation patterns, and environmental impacts in regions historically affected by Dust Bowl drought conditions.
Images are provided in GeoTIFF format, suitable for GIS applications, historical land cover analysis, and temporal change detection
Historical Remote Sensing Analysis of Dust Bowl Drought in Kansas: Mosaicked Images from 1936 to 2012
No full textThis dataset supports the study "Historical Remote Sensing Analysis of Dust Bowl Drought in Kansas" and includes a collection of corrected and mosaicked aerial and satellite images spanning from 1936 to 2012. The aerial imagery consists of scanned historical photographs from 1936 that have been georeferenced and mosaicked to provide seamless coverage of Hamilton County, Kansas. Subsequent imagery includes satellite data that has been processed to ensure spatial consistency throughout the time series.
To optimize download and storage efficiency, the dataset has been resampled to a resolution of 20–50 meters. However, users requiring higher spatial precision may resample the data down to the original resolution of 1 meter, as needed for detailed analysis.
The data are provided in GeoTIFF format and are suitable for GIS-based temporal change detection, land use/land cover analysis, and environmental impact assessments in region historically impacted by Dust Bowl drought conditions
Historical Remote Sensing Analysis of Dust Bowl Drought in Kansas: Corrected and Georeferenced 1972 Aerial Photographs
No full textThis dataset includes a collection of corrected and georeferenced overlapping aerial photographs from 1972, created to support the study "Historical Remote Sensing Analysis of Dust Bowl Drought in Kansas." The original images have been processed to correct distortions and aligned using georeferencing techniques, producing an accurate and seamless spatial representation of Hamilton County, Kansas. The overlapping nature of the photographs allows for stereo interpretation and enhanced visual analysis, making it possible to extract terrain features and assess land surface conditions in greater detail. This dataset is particularly valuable for evaluating land use changes, vegetation patterns, and environmental impacts in regions historically affected by Dust Bowl drought conditions.
Images are provided in GeoTIFF format, suitable for GIS applications, historical land cover analysis, and temporal change detection
A FRET based high content screen identifies DMPK as a novel tether of ER and mitochondria
Get PDFInter-organelle communication is a key feature of basic eukaryotic cells functions and of numerous cell signaling events (Bravo-Sagua et al., 2014). One of the best-characterized interorganelle cross talk is that between Endoplasmic Reticulum (ER) and mitochondria(Lopez-Crisosto et al., 2015). Also referred to as mitochondria associated ER-membranes (MAMs), the existence of mitochondria-ER contacts was uncovered 50 years ago through electron microscopic studies(Copeland and Dalton, 1959). The 90s saw the first break-through in functional significance of the MAMs, when Vance and Rizzuto et al., showed that exchange of phospholipids and calcium transfer occurs between the two organelles(Rizzuto et al., 1998; Vance, 1990). Despite the importance of the tether in metabolism and disease(Cali et al., 2013; Giorgi et al., 2015; Vance, 2014), only few proteins have so far been described to maintain the structural integrity of the tether in mammals (Lopez-Crisosto et al., 2015). MFN2was the firststructural tether to be identified. ER localized MFN2 forms homo and heterotypic interactions with mitochondrialMFN2 and MFN1, thus tethering the two organelles. As residual juxtapositionexist in Mfn2-/-cells, yet to be discovered tethersmust exist (de Brito and Scorrano, 2008). Hence, we set out to perform a genome wide screening to identify the structural components of the tether in mouse embryonic fibroblasts (MEFs). In order to perform the genome wide screening, we capitalized on the FRET based biosensor developed by Csordas et al., where CFP fused with FRB domain and YFP fused with FKBP domain were targeted to ER
(by a Sac 1 signaling sequence) and mitochondria (by an Akap signaling sequence) respectively (Csordas et al., 2010). We modified this biosensor by driving expression of both fluorescent molecules from a single mRNA, introducing between their cDNAs a self-cleaving Tav2A peptide(Luke et al., 2008). This modification allows expressing equimolar level of the proteins.
Thanks to FKBP and FRB binding domain, which interacts upon addition of rapamycin, we were able to study the basal and maximal level of juxtaposition between the two organelles. We then utilized this modified biosensor to perform a high content screen to identify molecules that either tether or space ER and mitochondria. We termed them as tethers and spacers respectively. We analyzed raw images from the screen and calculated the maximum number of contacts possible for every gene. Following automated image analysisand statistical analysis using R programming in cellHTS2 package of the primary screen performed on ~10,000 genes, we identified 14.4% genes as ER-mitochondria tethers (i.e., genes that once ablated increase the distance between the two organelles) and 5.3% genes as spacers (i.e., genes that once ablated decrease the distance between the two organelles). Pathway analysis using reactome and Panther predicted both existing and new pathways that are yet to explored in terms of ERmitochondria communication. Subcellular localization analysis of the tethers revealed eight proteins predicted to be present in both ER and outer mitochondrial membrane (OMM). One of the eight is myotonic dystrophy protein kinase (DMPK) and we have further characterized how DMPK tethers ER and mitochondria. DMPK is mutated in myotonic dystrophy 1 (DM1) (Cho and Tapscott, 2007). Having six known isoforms based on alternate splicing in humans and mouse (Wansink et al., 2003), DMPK’s role in myotonic dystrophy is not yet understood completely since the KO model of this gene developed late onset of myopathy and cardiac contractile dysfunction (Reddy et al., 1996). The subcellular localization either to ER or to mitochondria of the isoforms have been identified, although very less emphasis has been given to the functional relevance of different sub-cellular localizations. In conclusion, we have developed a new method to assess the proximity of ER and mitochondria and we have utilized this technology in a high content screen to identify novel structural components of the tether. The data from the screen has also spanned several existing pathways where ER-mitochondria junction has been implicated but not completely understood. Hence, the molecules identified from our screen, will help in unraveling the molecular players in these cellular pathways
Adversarial NER paper data/code
No full textCode and Data for the following paper:
"A Multilingual Evaluation of NER Robustness to Adversarial Inputs"
Akshay Srinivasan and Sowmya Vajjala
To appear in 8th Representation Learning for NLP workshop at ACL 2023
Paper pdf will be linked to soon. </p
Motion planning in Prototypical Corridors
No full textWe discuss the motion planning of a rectangular moving object in certain prototypical situations arising in a 2-D isothetic workspace. We have suggested three possible motion strategies involving rotation and translation of the moving object negotiating an L-shaped corridor. We have also given simulation results to compare the three cases of the proposed motion. E-mail: [email protected] First author's affiliation: Department of Computer Science James Cook University of North Queensland Townsville QLD 4811, Australia 1 Introduction Motion planning is required for moving a robot from a source placement (s) to a destination placement (d) within a workspace occupied by obstacles. Motion planning for a mobile robot can be viewed as a two-level process. At level one, the primary interest is in solving the FINDPATH problem, called path planning under global constraints. The result of this level is a path description of the desired motion from s to d. Once a path is proposed by leve..
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