103,318 research outputs found
Introduction: Urban plots, organizing cities
No full textThis chapter explores the processual nature of urban phenomena, considering the organizational aspects of urban space and the material features of organizations as having a common, heterogeneous ground. A matter of concern is the machinery around which entities are assembled and challenged. Cities are intrinsically indeterminate entities, and they are constantly constructed through controversies where action is distributed among actors and actants that assemble, re-present and translate each other. The issue of public noise in the historic city centre as reported in the local newspapers provided useful insights into this mechanism. The chapter comprises various contributions in which memory has become a major issue within discussion on urban reorganization. Grning's analysis is emblematic in this regard, because it deals with the urban transformation of East German cities, and particularly with the tangle of symbolic and material traces of the city of Leipzig
Territori della Cultura
No full textLa valutazione ex ante così come i criteri di selezione utilizzati nei bandi per i progetti culturali a finalità anche sociale possono incidere sulla qualità dei progetti, in quanto la valutazione può svolgere un ruolo educativo/adattivo: la struttura e i criteri da seguire per predisporre la proposta informano un certo modo di elaborare e presentare i contenuti, di pianificare le attività; di coinvolgimento degli attori locali ed esterni. L’articolo individua alcuni aspetti dei metodi di valutazione che possono influenzare/innalzare il livello della progettazione culturale nella prospettiva delle istituzioni locali
Limiti e potenzialità della valutazione in progetti di sviluppo locale. Alcune riflessioni a partire da un’esperienza valutativa di sperimentazioni di imprese sociali
No full textRumori indecorosi. L’organizzazione sonora dei centri storici
No full textSiamo a Trento. Il 19 febbraio 2008 un articolo a fondo pagina di un quotidiano locale titola: “Giro di vite sull’arte di strada”. Il consiglio comunale sta approvando delle modifiche al regolamento di polizia urbana che prevedono misure restrittive per l’arte di strada. Questo perché, scrivono i giornali, la polizia municipale riceve continue lamentele da parte di chi risiede e lavora in centro: “Credetemi, – è il ritornello – ascoltare per ore ‘O sole mio’ sotto l’ufficio non è affatto piacevole”
Mechanism of action and neuroplastic potential of the 5-HT2A serotonin receptor agonist psilocin
No full textMajor depressive disorder (MDD) is a debilitating illness characterized by depressed mood, anhedonia, and impaired cognitive function. In the last few years, several compounds from various pharmacological classes emerged as promising rapid-onset antidepressant agents, including serotoninergic agonists. These drugs, collectively known as fast-acting antidepressants, demonstrate clinical effectiveness within 24 hours from the first administration and their effects persist long after the compounds have been eliminated from the bloodstream. It is believed that this clinical effect is driven by the promotion of long-term structural and functional neuroplasticity in the prefrontal cortex (PFC), a brain region known to experience neuronal atrophy in patients with MDD. Among all these molecules, a great interest garnered around the therapeutic potential of serotonergic psychedelics, especially psilocybin and its active metabolite psilocin. Psilocin is a partial agonists of the serotonin receptor 5-HT2A (5-HT2AR). 5-HT2ARs are G-protein coupled receptors that are densely expressed by post-synaptic neurons of the PFC, where they promote the excitatory effects of serotonin via the activation of the Gq/11 signaling cascade. Despite the role of 5-HT2ARs in the hallucinogenic effect of these molecules is well documented, their involvement in the neuroplastic effect, and whether this action is mediated by the canonical Gq/11 signaling pathway originating at the plasma membrane or by different signal transduction routes, is still unclear.
The work described in this thesis is conceived within a collaboration with MGGM LLC, a company interested in the clinical development of psilocybin and its derivates. Notably, MGGM LLC recently submitted a clinical trial application for a preliminary Phase 1 study of a new, extended-release psilocybin formulation. The aim of the project is to investigate the mechanism of action and neuroplastic potential of molecules targeting 5-HT2ARs. A recent study suggests that psilocin, after entering neurons, might promote neuroplasticity through the activation of intracellular 5-HT2ARs. An intriguing idea is that psilocin becomes protonated and trapped in acidic compartments, accumulating and explaining its prolonged effects. To investigate this possibility, we developed a fluorescent-labeled psilocin derivative that we used as a probe for exploring the intracellular distribution of psilocin.
By testing the new probe on primary cortical neurons and neuronal cells, we demonstrated that it mirrors the biological activity of psilocin in terms of 5-HT2AR activation and dendritic spine plasticity, endorsing its use as a strategic tool to explore psilocin mechanism of action. Using various microscopy imaging techniques, results obtained with this probe allowed us to shed new light on the intracellular distribution of psilocin. Preliminary data, aimed at assessing the role of psilocin accumulation in the neuroplastic outcome, suggest that psilocin retention inside acidic compartments might indeed contribute to prolong its neuroplastic action even upon a brief, transient stimulation. If confirmed, these data would explain why psilocin and other protonable membrane-permeable psychedelics promote long-term clinical effect after a single dose.
Our approach, that we are currently implementing with ex vivo and in vivo methodologies, represents a novel, powerful strategy to comprehend the contribution of intracellular acidic compartments in the pharmacology of other fast-acting antidepressants. This will also lay the groundwork for the rational design of new serotoninergic agonists that leverage drug retention within acidic compartments
Entrevista a Jaume Pérez Montaner
No full text[ES] El equipo de Folias y el equipo de la revista Sonda entrevista a Jaume Pérez Montaner.Martínez Barragán, C.; Martínez Pérez, A.; Cano Rojas, G. (2016). Entrevista a Jaume Pérez Montaner. Revista Sonda: Investigación y Docencia en Artes y Letras. 5:92-105. https://doi.org/10.4995/sonda.2016.18410OJS92105
Impulso y transformación en Viento y Latido
No full text[ES] Reseña de "Viento y Latido", de Heriberto Morales Vindel, Editorial Ars Poética, Colección Sole Note, dirigida por Jesús Urceloy.Cano Rojas, G. (2021). Impulso y transformación en Viento y Latido. Revista Sonda: Investigación y Docencia en Artes y Letras. 10:251-256. https://doi.org/10.4995/sonda.2021.17844OJS2512561
The endangered artistic world, according to G. Lipovetsky
No full text[EN] Following closely the thought process of Gilles Lypovetsky, we have a compass in order to sustain our vision in the world, that of creativity and vibrancy of art in general. It is only from the truth that we can reconstruct an educational project without illusion.Society structures that sense of narcissism through various ways which are the following: the ongoing seduction, complete indifference, the strategy of isolation, the radical individualism of postmodernity, the major publicizing characterized by changing fashions and the humorous perspective of one s conscience, of the religious, and lastly, modern violence as an instrument that isn t balanced but is of free expression.Capitalism hasn t merely structured our environment but has also structured our spirit, in which we are consumed.[ES] Acercándonos al pensamiento de Gilles Lipovetsky obtenemos la brújula que nos sostiene la mirada en un mundo, el de la creatividad y la vivencia del arte en general, con tendencias a la endogamia y la autoreferencialidad. Sólo desde la verdad se puede reconstruir un proyecto educativo sin la ilusión autocomplaciente.Hoy en día la creatividad y la expresión artística están vehiculadas por el monopolio del capitalismo artístico. Esta sociedad estructura ese sentido narcisista a través de algunas claves como son: la seducción continua, la pura indiferencia, la estrategia del vacío, el radical individualismo del posmodernismo, la metapublicidad caracterizada por las modas líquidas y la perspectiva humorística de la propia conciencia, de lo religioso, de las instituciones y por último las violencias modernas cono instrumento no que equilibrio sino de gratuita expresión.El capitalismo no sólo ha estetizado nuestro entorno, sino que también ha sabido estetizar nuestro alma, en tanto que consumidores.Medina Rodríguez, JJ.; Rodríguez Peralta, MI. (2015). El mundo artístico hipotecado, según G. Lipovetsky. Revista Sonda: Investigación y Docencia en Artes y Letras. 4:6-15. https://doi.org/10.4995/sonda.2015.18413OJS6154HAN, B. Ch. La agonía del Eros. Barcelona, Herder. 2014. https://doi.org/10.2307/j.ctvt9k1shLIPOVETSKY, G. El crepúsculo del deber. Barcelona: Anagrama. 1994.LIPOVETSKY, G. El imperio de lo efímero. Barcelona: Anagrama, 1996.LIPOVETSKY, G. La era del vacío. Barcelona: Anagrama. 2000.LIPOVETSKY, G. El lujo eterno. Barcelona: Anagrama. 2006.LIPOVETSKY, G. La estilización del mundo: vivir en la era del capitalismo artístico. Barcelona: Anagrama. 2015Entrevista a LIPOVETSKY G. 30/8/2009 Cómo las pantallas tomaron el mundo, rescatado de: www.pagina12.com.ar. https://docs.google.com/viewer?a=v&pid=sites&srcid=ZGVmYXVsdGRvbWFpbnxiaWJsaW90ZWNhZGlnaXRhbDMyYnxneDo0NzFlNzFlNjY5NjhmZjJlEntrevista a LIPOVETSKY G. 25/01/2015 La gente común no halla ya la felicidad en el súper, por eso escribe o hace fotos, rescatado de http://www.elmundo.es/cronica/2015/01/25/54c39959e2704e8d4c8b457c.htmlRUIZ Sánchez, J. C. De Guy Debord a Gilles Lipovetsky: el tránsito de la categoría de lo social hacia la categoría de lo individual. Universidad de Córdoba. Servicio de Publicaciones. 2010 Sébastien C. La philosophie française en questions. Entretiens avec Comte-Sponville, Conche, Ferry, Lipovetsky, Onfray et Rosset. Paris: Le Livre de poche. 200
Muri come trame e infrastrutture urbane. Organizzare la città attraverso sensi, pratiche, narrative, controversie
No full textCome operano i muri nel dare forma allo spazio e alle pratiche urbane? Di che cosa sono fatti? Il capitolo propone una riflessione sui muri
urbani interrogandosi sulla loro composizione, sulla capacità d’azione
e sulla dimensione organizzativa che essi chiamano in causa. Lo studio
prende le mosse dall’analisi di alcune controversie urbane che hanno
avuto luogo nella città di Trento e che hanno avuto risalto nella stampa
locale. Si tratta di episodi che permettono di seguire il modo in cui lo
spazio prende forma nelle narrazioni e nelle pratiche. Il materiale giornalistico raccolto non è stato trattato tanto per la funzione informativa
quanto per la capacità performativa delle notizie di orientare il discorso
pubblico (Park 1949): nel connotare e organizzare il discorso degli spazi,
la stampa locale contribuisce infatti a creare un immaginario e uno status specifico del luogo
Presentación
No full text[ES] Presentación nº 5Cano Rojas, G. (2016). Presentación. https://doi.org/10.4995/sonda.2016.18398OJ
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