1,720,985 research outputs found
Photosensitized Inactivation of ProtozoaPathogenic Agents of Water- and Vector-Borne Diseases
No full textSeveral protozoa are recognized etiological agents of dangerous water- and vector-borne
diseases, and some of them are among the most dangerous and deadly of human pathogens. Diseases
such as amoebiasis, leishmaniasis, trypanosomiasis, and malaria are among the most fatal infections for
humans. Despite major advances in medicine in the last century, infectious diseases continue to present
enormous global health problems. Antibiotic therapy for the infections caused by pathogenic protozoa is
generally empirical, and patient recovery is often problematic, but some forms of combination therapy
have proven more successful than single-drug therapies. New approaches that are effective, affordable,
and widely applicable and that are not susceptible to resistance are urgently needed. The effectiveness
of antimicrobial photodynamic therapy (PDT) as a novel mode of treating some diseases caused by
eukaryotic microorganisms has been demonstrated against some protozoan pathogenic species. PDTs
offer alternative approaches in the medical and environmental control of pathogenic agents as well as
the sterilization of blood products
Use of tetraalkyl phenothiazine derivatives as photodynamic agents in the treatment of microbial infections.
No full textPhotosensitized inactivation of protozoa in the medical and environmental control of water-borne diseases.
No full textSunlight-activatable porphyrin photosensitisers as environmentally safe larvicidal agents: studies with larvae of Aedes albopictus
No full textPhotodynamic inactivation of microbial pathogens: disinfection of water and prevention of water-borne diseases.
No full textPorphyrins have been shown to act as very efficient photosensitizing agents against a broad number of microbial pathogens, including bacteria, fungi, and protozoa. This property has promising applications at a clinical level for the treatment of infectious diseases by photodynamic therapy. Moreover, this technique is also being used to address environmental problems of high significance, such as the decontamination of wastewaters, the disinfection of fish-farming tanks, the protection of animal species (e.g., amphibians and reptiles) that are endangered by pathogens whose life cycle takes place largely in aqueous media, and the control of populations of noxious insects. Such diversified applications take advantage of the availability of a truly large number of porphyrin derivatives with chemical structures that can be tailored to comply with the physical and chemical properties as well as the biological features of several milieus. In addition, the property typical of porphyrins to absorb essentially all of the wavelengths in the sun emission spectrum allows the promotion of processes largely based on natural resources with significant energy savings and low impact on ecosystems
Porphyrin-photosensitized processes: an environmentally friendly approach to water disinfection.
No full textPorphyrin-photosensitized inactivation of protozoa in the trophozoitic and cystic stage.
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