1,721,001 research outputs found
Activation of the endogenous interferon system, expression of interferon-alpha receptors, and response to interferon therapy in chronic hepatitis C
No full textOmega-3 Polyunsaturated Fatty Acids in the Treatment of Non-Alcoholic Fatty Liver Disease: Are They So Good?
No full textEditorial. No abstract available
Signs and Symptoms
No full textHepatocellular carcinoma (HCC) is often diagnosed after the tumor manifests clinical signs
and symptoms. Early diagnosis is usually performed thanks to HCC screening programs for
patients affected by liver cirrhosis or chronic viral hepatopathies using ultrasound and serum
alfa-fetoprotien. In most HCC cases, clinical signs and symptoms of this tumor may occur
several months after development, when therapy can not be curative, given the advanced
tumor stage and underlying liver disease, which preclude curative options, such as ablation,
resection, or liver transplantation.
Clinical features of HCC are often similar to those caused by the underlying hepatic disease.
It is very hard for physicians to distinguish signs and symptoms of HCC in contests characterized
by an advanced liver disease. Advanced liver cancer can be responsible for accelerated
liver functions deterioration caused by the intrahepatic tumor growth.
In this chapter, we review the clinical signs and symptoms induced by advanced carcinoma.
We also discuss particular clinical scenarios caused by metastases and paraneoplastic syndromes,
sometimes described case reports in literature
Omega-3 Polyunsaturated Fatty Acids in the Treatment of Non-Alcoholic Fatty Liver Disease: Are They So Good?
Full text linkCirculating standard CD44 isoform in patients with liver disease: Relationship with other soluble adhesion molecules and evaluation of diagnostic usefulness
No full text
Effects of antihypertensive drugs on alcohol-induced functional responses of cultured human endothelial cells.
No full textAlcohol-induced endothelial changes might contribute to an increase in blood pressure in regular alcohol consumers. Some antihypertensive drugs affect oxidative stress and endothelial function and might counteract the effects of alcohol at the cellular level. The aim of this study was to investigate in vitro the effects of three different types of anti hypertensive agents on alcohol-induced endothelial responses and oxidative stress. Cultured human endothelial cells were exposed to increasing concentrations (1, 10, 60 mu mol/L) of zofenoprilat, carvedilol, and lacidipine in the absence and in the presence of ethanol (140 mmol/L). Concentrations of endothelin (ET) and nitric oxide (NO) were measured in the culture media as markers of endothelial function, and malondialdehyde (MDA) and intracellular glutathione (GSHi) were measured as markers of oxidative stress. Exposure to alcohol increased the levels of ET, NO, and MDA, and decreased GSHi. Carvedilol and zofenoprilat were more effective than lacidipine in counteracting the effects of alcohol on ET production. Alcohol-induced NO production was enhanced by carvedilol, whereas zofenoprilat and lacidipine did not have a significant effect. The alcohol-induced increase in MDA concentrations was blunted by all three drugs, but only carvedilol restored a normal response. All three drugs increased GSHi levels, with the effect being greater for carvedilol and lacidipine than zofenoprilat. Carvedilol is more effective than zofenoprilat and lacidipine in counteracting alcohol-induced endothelial responses in vitro and in decreasing oxidative stress. These effects might be particularly beneficial in patients with alcohol-related hypertension
Acetaminophen-induced liver injury in a woman with febrile flare of systemic lupus erythematosus
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