2,638 research outputs found
Reformulating the rj-McMC Algorithm for 3D Inversion of Passive Seismic Data for Near-Surface Characterization
No full textGeophysical subsurface characterization techniques could, due to their non-invasive nature, play a crucial role in the design and subsequent construction of infrastructure in urban & industrial environ- ments. Geo-data specialist company Fugro sees potential in upgrading their current ambient-seismic- noise-tomography workflow, to make use of state-of-the-art inversion schemes with the main goal of increasing the quality and accuracy of the initial-site characterization delivered to clients. In this thesis I explore the feasibility of utilizing the reverse-jump Markov chain Monte Carlo (rj-McMC) algorithm for the inversion of ambient seismic noise for characterization in urban & industrial environments. Specif- ically, testing the potential of scaling down this inversion algorithm to fit in a small scale, near-surface framework. To achieve this, I first carried out analyses to evaluate the appropriate Rayleigh wave frequency range, after which realistic noise hyperparameters, suited for this reduced scale problem, were obtained. Because of the potential exploitation of in-situ borehole measurements, I reformulated the Bayesian prior within the rj-McMC algorithm to implement these constraining shear wave velocity values appropriately. I conducted extensive synthetic experiments to gain insight into the behavior of this adapted algorithm, from which it was concluded that the inherent dynamic discretization partially prevents these constraints from being implemented to their full extent. Nevertheless, promising results lead me to conclude that the use of the rj-McMC algorithm for application in near-surface urban & industrial environments is feasible.Applied Geophysics | IDEA Leagu
Interventions to prevent vertical transmission of HIV-1: effect on viral detection rate in early infant samples.
No full textClowns, Fools, and Killers: An Exploration of Horror, Comedy, and Madness Through the Roles of Murderer 2 and Sir Richard Ratcliffe in William Shakespeare\u27s Richard III
No full textThis document is a thesis submitted in partial fulfillment of the Master of Fine Arts degree in Theatre Arts with a Concentration in Musical Theatre. It is a detailed account of author RJ Magee’s artistic and scholarly process in creating the roles of Murderer 2 and Sir Richard Ratcliffe in William Shakespeare’s Richard III. The production was performed as part of Minnesota State University, Mankato’s mainstage season in October of 2022. In five chapters, this thesis chronicles the actor’s process: a preproduction analysis, a historical and critical perspective, a rehearsal and performance journal, a post-production analysis, and a process development analysis. Appendices and works cited are included
Radiation-induced root surface caries restored with glass-ionomer cement placed in conventional and ART cavity preparations: Results at two years
No full textThe document attached has been archived with permission from the Australian Dental Association (8th Jan 2008). An external link to the publisher’s copy is included.Background: There are no published studies comparing the clinical performances of more-viscous glass-ionomer cement (GIC) restorations when placed using conventional and atraumatic restorative treatment (ART) cavity preparation methods to restore root surface caries. Methods: One dentist used encapsulated Fuji IX GP and Ketac-Molar to restore 72 conventional and 74 ART cavity preparations for 15 patients who had received cervicofacial radiation therapy. Two assessors evaluated the restorations at six, 12, and 24 months for retention, marginal defects and surface wear, and recurrent caries. Results: After two years, the cumulative restoration successes were 65.2 per cent for the conventional and 66.2 per cent for the ART cavity preparations, without statistical or clinical significance (P>0.50). Restoration dislodgement accounted for 82.8 per cent and marginal defects for 17.2 per cent of all failures. There were no instances of unsatisfactory restoration wear or recurrent caries observed. Teeth with three or more restored cervical surfaces accounted for 79.3 per cent of all failures (P<0.0001). Conclusions: For root surface caries restored with GIC, the use of hand instruments only with the ART method was an equally effective alternative to conventional rotary instrumentation for cavity preparation. Larger restorations had higher failures, usually from dislodgement.JY Hu, XC Chen, YQ Li, RJ Smales and KH Yi
Paediatric use of melatonin (Author reply to D. J. Kennaway).
No full textComment on
Paediatric use of melatonin. [Eur J Paediatr Neurol. 2015]
Current role of melatonin in pediatric neurology: clinical recommendations. [Eur J Paediatr Neurol. 2015
IMPACT OF HIV PROJECT ECHO (EXTENTIONS FOR COMMUNITY HEALTH OUTCOMES) IN KAZAKHSTAN
No full textIn 2016, Kazakh Medical University for Continuous Education (KazMUCE) in collaboration with Columbia University and the US CDC, conducted a pilot program to replicate Project ECHO, a weekly innovative, virtual mentoring and training CME platform for healthcare workers. A 10-month HIV case-based curriculum was developed and implemented by KazMUCE, which served as a Training Center for the for 24 HIV treatment facilities located throughout the country. An evaluation was developed aimed at exploring the value of Project ECHO as a CME model in Kazakhstan using the desired outcomes from each level in Moore’s Expanded CME Evaluation Framework. The study objective was to evaluate the relationship between Project ECHO and capacity-building among clinicians for providing high-quality care for people living with HIV in Kazakhstan. Methods included conducting and analyzing pre- and post- knowledge assessments, self- efficacy, and satisfaction surveys among all participants, as well as conducting nine in-depth interviews and five focus group discussions among participants.
There was over 90% participation in all sessions from 97 participants across all 24 HIV treatment sites in Kazakhstan. The pre- and post-knowledge assessment showed that 75% (n=73) of participants increased their score from the baseline. The surveys showed an increase of 28% in self-efficacy and an increase of 19% in job satisfaction. In the focus groups and interviews participants shared that they appreciated being involved in a community of practice and having evidence-based concepts reinforced through the real-time practical case presentations and short didactic sessions. Providers also mentioned that the case-based learning provided a unique opportunity for providers to gain information to apply in their service delivery. Reports from respondents suggest that providers improved their performance, specifically the quality of prescribing effective treatment, managing side effects of the treatment as well as complications associated with HIV infection. As a result, providers shared that their patients’ outcomes have improved.
The high degree of site participation, individual attendance, and support for the program among healthcare workers suggests that Project ECHO is a feasible model of CME in Kazakhstan, which could be expanded to other specialties and medical cadres.Doctor of Public Healt
Platelet-rich plasma and macular hole surgery: A clue to their mode of action and the influence of anti-platelet agents
No full text\ua9 The Author(s) 2022. Purpose: To present a case of refractory full-thickness macular hole (FTMH), in which autologous platelet-rich plasma (aPRP) was used on two consecutive occasions, and associated with successful closure only after complete cessation of anti-platelet therapy. Methods: Interventional case report. Results: A 63-year-old male with Alport syndrome underwent pars plana vitrectomy with internal limiting membrane peeling and gas for a large FTMH. The patient was on systemic anti-platelet agents for coronary disease. Post-operatively, the FTMH remained open and repeated surgery, augmented with aPRP, was performed. Although a thick pre-retinal coagulum was evident on optical coherence tomography on day one post-surgery, the second surgery failed. Ultimately, successful aPRP-augmented surgical closure of the FTMH was achieved only after complete cessation of systemic anti-platelet agents. Conclusion: Appropriate management of anti-platelet therapy may be relevant when planning aPRP use, though further large-scale studies are needed to assess the precise effect of anti-platelet therapy on the efficacy of aPRP, and to confirm the potential role of aPRP in patients with Alport syndrome
Needle deflection in thermal ablation procedures of liver tumors: a CT image analysis
No full textIntroduction: Accurate needle placement is crucial in image-guided needle interventions. A targeting error may be introduced due to undesired needle deflection upon insertion through tissue, caused by e.g. patient breathing, tissue heterogeneity, or asymmetric needle tip geometries. This paper aims to quantify needle deflection in thermal ablation procedures of liver tumors by means of a CT image analysis. Methods: Needle selection was done by using all clinical CT data that were made during thermal ablation procedures of the liver, ranging from 2008-2016, in the Erasmus MC, the Netherlands. The 3D needle shape was reconstructed for all selected insertions using manual segmentation. Subsequently, a straight line was computed between the entry point of the needle into the body and the needle tip. The maximal perpendicular distance between this straight line and the actual needle was used to calculate needle deflection. Results: In total, 365 needles were included in the analysis ranging from 14G to 17G in diameter. Average needle insertion depth was 95mm (range: 32 mm – 182 mm). Needle deflection was on average 1.3 mm (range: 0.0 mm – 6.5 mm). 54% of the needles (n=196) had a needle deflection of more than one millimeter, whereas 7% of the needles (n=25) showed a large needle deflection of more than three millimeters. Conclusions: Needle deflection in interventional radiology occurs in more than half of the needle insertions. Therefore, deflection should be taken into account when performing procedures and when defining design requirements for novel needles. Further, needle insertion models need to be developed that account for needle deflection.Medical Instruments & Bio-Inspired Technolog
Pharmacological interventions for patients experiencing acute post-operative pain
No full textWhat is pain? It is an unpleasant sensory and emotional experience associated with actual or potential tissue damage. What are goals for postoperative pain management?To increase a patients quality of life, to facilitate a full and healthy recovery, to decrease the risk for complications (Impaired mobility -
pneumonia, pressure ulcers, DVT), to allow for early discharge from the hospital. Conclusion: by using a combination of pharmacological interventions we can more accurately provide pain management to patients by addressing multiple types of pain at once. By performing a thorough pain assessment and using our clinical judgement to determine what pharmacological interventions are necessary, we can move closer to achieving our postoperative pain management goals.Not peer reviewedStudent Research Day Poster (2017
Response-dependent two-phase sampling designs for biomarker studies
No full textTwo‐phase sampling designs are developed and investigated for use in the context of a rheumatology study where interest lies in the association between a biomarker with an expensive assay and disease progression. We derive optimal phase‐II stratum‐specific sampling probabilities for analyses from parametric maximum likelihood (ML), mean score (MS), inverse probability weighted (IPW) and augmented inverse probability weighted estimating equations (AIPW). The easy‐to‐implement optimally efficient design for the MS estimator is found to be asymptotically optimal for the IPW and AIPW estimators we consider, and is shown to result in efficiency gains over balanced and simple random sampling even when analyses are likelihood‐based. We further demonstrate the robustness of this optimal design and show that it results in very efficient estimation even when the model or parameters used in its derivation are misspecified. This is the peer-reviewed version of the following article: McIsaac, M. A., & Cook, R. J. (2014). Response-dependent two-phase sampling designs for biomarker studies. Canadian Journal Of Statistics, 42(2), 268-284. doi:10.1002/cjs.11207, which has been published in final form at http://doi.org/10.1002/cjs.11207. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Version
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