1,721,294 research outputs found
AIDS-related Kaposi's sarcoma: principal pathogenic mechanisms
No full textKaposi's sarcoma (KS) is the most common malignancy that affects patients with HIV infection. Considerable progress has recently been achieved in understanding the pathogenesis of this vascular malignancy. A novel herpesvirus has been detected in KS lesions of all types, in skin-lesions of post-transplant immunosuppressed individuals and in various lymphoproliferative disorders. Apart from this, the increased severity of this neoplasm in patients infected with HIV may be due to HIV-derived tat protein synergising with cytokines and chemokines with angiogenetic activity. Finally, the lower incidence of the malignancy in females may be related to a protective effect of human chorionic gonadotrophin (HCG), presumably mediated by its effect on microvasculature. All these advances suggest new possibilities in the management of the disease
Systemic chemotherapy for patients with advanced and metastatic bladder cancer: Current status and future directions
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Extensive small cell lung cancer: Standard and experimental treatment approaches in elderly patients
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Torch study: How much longer should we continue to use erlotinib in unselected patients with non-small-cell lung cancer?
No full textRole of liposomal anthracyclines in breast cancer
No full textAnthracyclines are among the most effective drugs for patients with breast cancer. Their use, however, has been limited by associated toxic effects, including myelosuppression, alopecia, nausea and vomiting, stomatitis, and most importantly, cardiotoxicity. Liposomal anthracyclines were developed to increase the therapeutic index of conventional anthracyclines by maintaining antitumor efficacy while improving the safety profile. There are currently two liposomal formulations available for treatment of advanced disease: a not pegylated liposomal doxorubicin and a pegylated liposomal doxorubicin. This review will focus on both liposomal formulations of doxorubicin which are approved in Europe and Canada for use in patients with metastatic breast cancer
Synchronous Mandibular and Giant Parieto-occipital Skull Metastasis From Hepatocellular Carcinoma
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