2 research outputs found
EFFECTS OF LIGNOCAINE NEBULIZATION VERSUS DEXMEDETOMIDINE NEBULIZATION IN BLUNTING HEMODYNAMIC RESPONSE IN PATIENTS UNDERGOING NASOTRACHEAL INTUBATION IN HEAD AND NECK SURGERIES
No full textObjective: The objective of this study was to compare the efficacy of nebulized lignocaine and dexmedetomidine in attenuating the hemodynamic response to nasotracheal intubation in patients undergoing head and neck surgeries.
Methods: This prospective interventional comparative study included 192 ASA I–II patients aged 18–60 years scheduled for head and neck surgeries under general anesthesia. Patients were allocated to receive nebulization with lignocaine 1.5 mg/kg, dexmedetomidine 2 μg/kg, or normal saline (control) 15 min before intubation. Hemodynamic parameters – heart rate (HR), systolic, diastolic, and mean arterial pressures – were recorded at baseline, pre-intubation, and at 1, 5, 10, and 15 min post-intubation. Statistical analysis was performed using analysis of variance and Chi-square tests, with p<0.05 considered significant.
Results: Baseline characteristics were comparable among the groups. Dexmedetomidine nebulization produced significantly greater attenuation of increases in HR and blood pressure at all post-intubation time points compared with lignocaine and control (p<0.001). Lignocaine provided partial attenuation, whereas the control group displayed marked hemodynamic surges. Adverse events were minimal, with only mild, self-limiting bradycardia in the dexmedetomidine group.
Conclusion: Nebulized dexmedetomidine is more effective than lignocaine in blunting the hemodynamic response to nasotracheal intubation and represents a safe, non-invasive strategy for achieving perioperative hemodynamic stability
A COMPARATIVE STUDY OF THE EFFECTS OF ORAL PREGABALIN, ORAL CLONIDINE, AND A CONTROL GROUP ON ATTENUATION OF STRESS RESPONSE TO NASOTRACHEAL INTUBATION
No full textObjective: Endotracheal intubation, particularly nasotracheal intubation, induces a pronounced sympathetic response characterized by tachycardia, hypertension, and elevated plasma catecholamines. This stress response may be deleterious in patients with cardiovascular or neurological comorbidities. Pharmacological agents such as clonidine and pregabalin have been investigated for their potential to attenuate this hemodynamic surge. The study aims to compare the efficacy and safety of oral clonidine (300 μg) and oral pregabalin (150 mg) in attenuating the hemodynamic response to nasotracheal intubation.
Methods: In this prospective randomized comparative interventional study, 120 American Society of Anesthesiologists I-II adult patients (18–60 years) scheduled for elective surgeries requiring nasotracheal intubation were divided into three groups using a computer-generated random sequence: Group A received oral clonidine, Group B received oral pregabalin, and Group C served as control. The study was single-blinded, with patients unaware of group allocation. Hemodynamic parameters were recorded at baseline, immediately before induction, immediately after intubation, and at 1, 3, 5, and 10 min post-intubation. Adverse events were also noted.
Results: Baseline demographic and clinical characteristics were comparable across all groups. Both clonidine and pregabalin significantly attenuated the post-intubation rise in heart rate, systolic blood pressure, and diastolic blood pressure compared to the control group (p<0.001). Adverse events were infrequent, mild, and self-limiting, with no serious complications reported.
Conclusion: Oral clonidine and pregabalin are effective and safe pre-medications for attenuating the hemodynamic response to nasotracheal intubation, enhancing peri-intubation stability and patient safety
