1,721,001 research outputs found
On the presence and role of the so called "M cells" in rat Peyer's patches: an ultrastructural and immunocytochemical study.
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Immunohistochemical aspects of rat liver in normal conditions and after common bile duct ligation.
No full textFollicle associated epithelium in the rat peyer’s patches : a morphological, immuno-histochemical and morphometrical study.
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PPAR-γ with its anti-inflammatory and anti-fibrotic action could be an effective therapeutic target in IBD
Full text linkAbstract. – OBJECTIVE: Intestinal fibrosis is
a process characterized by an excessive deposition of Extracellular Matrix (ECM) proteins by
activated myofibroblasts and represents a consequence of a chronic inflammation that usually occurs during Inflammatory Bowel Disease
(IBD). The relationship between inflammation
and fibrosis in IBD remains still unclear and
nevertheless the recent pharmacological progresses, currently the only resolutive therapeutic strategy is surgery, especially when complications (stricture, stenosis and obstruction of
intestinal tracts) appear. As many different cellular types and molecular mechanisms are implicated in the pathogenesis of IBD, the identification of molecules able to counteract this process could be crucial.
MATERIALS AND METHODS: This is a literature review of several articles published on
PubMed databases.
RESULTS: A number of researches suggest
that Proliferator-Activated Receptor-gamma
(PPAR-γ) has both anti-inflammatory and anti-fibrotic effects in many organs. PPAR-γ has been
demonstrated to be able to downregulate pro-inflammatory cytokines production such as Interleukin (IL)-4,-5,-6 but also to interfere with profibrotic molecules as Platelet-Derived Growth
Factor (PDGF), IL-1 and Transforming Growth
Factor Beta (TGF-β), the main promoter of fibrosis. In preliminary clinical trials and in experimental models of intestinal fibrosis, natural and
chemical PPAR-γ ligands have ameliorated the
fibrotic process.
CONCLUSIONS: Since PPAR-γ could play a
crucial role in the development of the disease,
the research of new molecules, capable of ameliorating both inflammation and fibrosis lesions,
as PPAR-γ agonists, could represent a valid and
effective therapeutic approach for the prevention and treatment of IBD and intestinal fibrosis
Produzione di biofilm (slime layer) in isolati clinici ed ambientali di Candida Parapsilosis: studio della variabilità ed analisi ultrastrutturale (M.E.S.).
No full textBiofilm in isolati clinici ed ambientali di Candida parapsilosis: variabilità ed analisi ultrastrutturale.
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