1,720,994 research outputs found
Sentinel node biopsy in patients with cutaneous melanoma.Cafiero F, Peressini A, Gipponi M, Rainero ML, Villa G, Sertoli MR, Bertoglio S, Moresco L.
No full textAbstract
The role of elective lymph node dissection (ELND) for treatment of cutaneous melanoma is still debated. Initially, lymphatic mapping technique was performed by an intradermic injection of vital blue dye; subsequently, it was improved by the use of radioguided surgery (RGS). Preliminary experience with this technique proved effective for detection of clinical occult lymph node metastasis; it may also enable the surgeon to perform a selective lymph node dissection (SLND) to concentrate on pathologic node-positive patients for the same potential benefits that have been provided by ELND. We performed sentinel node biopsy on 48 patients with stage pT3N0M0 melanoma. Vital blue dye mapping only was carried out on 39 patients; the remaining nine patients had a combined lymphatic mapping with both blue dye and RGS. The sentinel lymph node (SLN) was identified in 46 of 48 patients (95.8%). Ten patients (20.8%) were found to have metastatic melanoma cells in their SLN(s); all these patients underwent SLND of the affected basin. Our findings confirm that the intraoperative lymphatic mapping of the SLN using both blue dye and radiodetection is an appropriate and simple technique for selecting patients who are more likely to benefit from lymph node dissection
A randomized trial of 5-fluorouracil alone vs 5-FU and high dose leucovorin in untreated advanced colorectal cancer patients
No full textHigh-dose chemotherapy shows a dose-dependent toxicity to bone marrow osteoprogenitors: a mechanism for post-bone marrow transplantation osteopenia.
No full textAdjuvant systemic treatment of resectable breast cancer: eleven years results of a monoinstitutional chemo-hormone-immunotherapy trial.
No full textDouble-blind randomized trial of lorazepam versus placebo with methylprednisolone for control of emesis due to non-cisplatin containing chemotherapy.
No full textCisplatin, methotrexate, and 5-fluorouracil combination chemotherapy for advanced ovarian cancer.
No full text[Merkel's tumor. Some comments and the authors' personal cases].
No full textThe clinical features of 7 cases of primary neuroendocrine carcinoma of the skin
(Merkel cell tumor) are reported. This cancer arises in the dermis and
subcutaneous tissues of elderly individuals. Natural history is characterized by
local recurrences (30%), regional lymph node metastases (65%) and distant
metastases (40%). Surgery is the elective treatment, chemotherapy and
radiotherapy resulted in only short-term palliative response
Preoperative chemotherapy and radiotherapy in the management of epidermoid carcinoma of the anal canal.
No full textChemotherapeutic treatment of advanced ovarian carcinoma. Preliminary results of the Piedmont-Liguria Cooperative Group]
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