1,720,981 research outputs found
The Histopathological and Immunohistochemical Features of Nipple Adenoma
No full textObjectives:Nipple adenoma is a benign breast tumor presenting with nipple erosion and bloody nipple discharge, causing the clinical suspicion of Paget’s disease, and creating difficulty in diagnosis due to the histopathologically complex morphological pattern. In our study, we aimed to examine the histopathological and immunohistochemical features of this rare tumor.Materials and Methods:For this purpose, 11 nipple adenomas diagnosed in Ankara University Faculty of Medicine, Department of Pathology between 2005 and 2020 were included in the study. Clinical information was obtained from patient files. Histomorphological and immunohistochemically p63, SMA, kaldesmon, ER and CK5/6 staining properties of the tumors were evaluated. Accompanying ductal carcinoma in situ or invasive carcinoma rates were recorded.Results:The mean age of the patients was determined to be 44.1 years (minimum: 25, maximum: 59) and it was observed that all of the patients were female. Clinical presentation was with bloody or serous nipple discharge, subareolar nodule or a palpable mass.The average tumor diameter was measured as 0.9 cm (minimum: 0.4 cm, maximum: 1.2 cm). Sclerosing papillomatosis (36.4%), mixed (36.4%) and papillomatosis (27.2%) growth patterns were observed. Erosion was detected in the epidermis at a rate of 36.4%. Necrosis and cytological atypia were observed in areas of florid hyperplasia with a rate of 18.2%. Concomitant invasive ductal carcinoma (18.2%), low nuclear grade ductal carcinoma in situ (9.1%) and invasive lobular carcinoma (9.1%) were seen. Immunohistochemical analysis revealed the presence of p63, SMA, caldesmon positive myoepithelial cells in adenoma areas, heterogeneous positivity with ER and expression loss was not observed with CK5/6.Conclusion:Nipple adenomas are rare tumors that clinically and pathologically require the differential diagnosis of malignancy. In addition, close clinical follow-up of the patients should be performed, since breast carcinoma can be observed in the adenoma or in another location in the breast simultaneously or afterwards
Diffuse Neuroendocrine Cell Hyperplasia: Report of Two Cases
Get PDFDiffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is a rare pulmonary disorder characterised by a proliferation of neuroendocrine cells within the lung. It is believed that a minority of the patients with DIPNECH can develop carcinoid tumors. Here, we report two new cases of DIPNECH with coexisting carcinoid tumors
Radiation Therapy for Stage I Primary Orbital Non-Hodgkin's Lymphomas
No full textAims and Background The orbit is an uncommon primary site for non-Hodgkin's lymphomas (NHL), and it accounts for less than 1% of all sites of primary presentations. We report the experience of the Department of Radiation Oncology at Ankara University Faculty of Medicine with radiation therapy in treatment of patients with stage I primary orbital NHL. Methods From February 1978 through August 1993, 14 patients with stage I primary orbital NHL were treated with radiation therapy. According to the Working Formulation classification, 8 patients had low-grade and 6 had intermediate-grade lymphomas. The most commonly used radiation therapy technique was a single anterior field with a Cobalt-60 unit, delivering 40 Gy in 2 Gy daily fractions. Two patients with intermediate-grade lymphomas received the CHOP regimen following radiation therapy. Results Follow-up ranged from 0.8 to 18.3 years (median, 10.3 years). Local control was achieved in all patients. Two patients with low-grade lymphomas relapsed locally and were successfully salvaged with radiation therapy. Three patients with intermediate-grade lymphomas failed systemically. Salvage therapy consisted of combination chemotherapy for 2 of them but was unsuccessful. Overall survival probabilities at 2, 5 and 10 years were 78.6%, 61.1% and 52.4%, respectively, for the entire group of 14 patients. Overall, cause-specific and disease-free survival probabilities were higher for patients with low-grade lymphomas than for those with intermediate-grade lymphomas (P = 0.03, P = 0.03 and P = 0.06, respectively). Cataracts were observed in 9 and lacrimal disorders in 4 patients. Conclusions The study suggests that among stage I primary orbital NHL, low-grade lymphomas could be treated with radiation therapy alone, whereas combination chemotherapy could accompany radiation therapy for intermediate-grade lymphomas. </jats:sec
Proximal bronchial extension with special reference to tumor localization in non-small cell lung cancer
No full textContribution of small tissue biopsy and flow cytometry to preoperative cytological categorization of salivary gland fine needle aspirates according to the Milan System: Single center experience on 287 cases
No full textHazards of the ‘Hard Cash’: Hypersensitivity Pneumonitis
Get PDFHypersensitivity pneumonitis (HP) is a nonimmunoglobulin E-related immune-mediated parenchymal lung disease. A 45-year-old woman who was a lifelong nonsmoker with a six-month history of frequent episodes of cough and dyspnea was admitted to hospital. She had been working as a money counter for 20 years at a central bank. Bibasilar crackles on lung auscultation, ground-glass opacities and a mosaic pattern on high-resolution computed tomography, restrictive abnormality on pulmonary function tests and mild hypoxemia were the prominent findings. Bronchoalveolar lavage fluid analysis revealed a predominance of CD4-positive T cells, and she tested positive on her natural challenge test. She was diagnosed with subacute HP based on established criteria. She was advised to discontinue counting fresh banknotes. Prednisolone was commenced, then tapered to discontinue in the ensuing six months. Clinical and radiological improvement was achieved within two months. To the authors’ knowledge, the present report is the first to describe ‘hard cash HP’, possibly caused by chipping dust or printing dye
Intrapulmonary Solitary Fibrous Tumour of the Lung: A Very Unusual Presentation
No full textSolitary fibrous tumour (SFT) is a rare neoplasm which most frequently occurs in the pleura, especially visceral pleura, but it is known that intrapulmonary SFT is very rare. We report the case of a 60-year-old woman who was admitted with a 6-year history of slow enhancing intrapulmonary nodular lesion in her right upper lobe on chest computed tomography (CT). A right upper lobectomy was performed for complete excision of the tumour and the postoperative histopathological examination revealed SFT. No pathology was observed during the period of 34-month postoperative follow-up. Herein we present an extremely rare case of intrapulmonary SFT that was located in the deep pulmonary parenchyma
Successful removal of a giant recurrent mediastinal liposarcoma involving both hemithoraces
No full textThyroid Gland Metastasis from Cancer of the Uterine Cervix: An Extremely Rare Case Report
No full textThe thyroid gland is a relatively uncommon site for a metastatic disease, although it is richly supplied with blood. The metastases may originate from various primary sites, mainly kidney, lung, head and neck, and breast. Thyroid metastasis from cervical carcinomas is extremely rare; and only a few cases have been previously reported in the literature. In patient with thyroid nodules and an oncological history, the possibility of thyroid metastasis should be seriously considered. Despite the rarity of the metastasis of cervical carcinoma to the thyroid, it is difficult to say appropriate treatment approach for these lesions. When managing such patients, decision-making should balance the possibility of gaining long-term survival against estimation of the aggressiveness of the disease and its possible complications. Here, a case of thyroid metastasis from a squamous cell carcinoma of the uterine cervix presenting with cervical mass and difficulty in swallowing and its treatment is reported
- …
