1,721,003 research outputs found
Optical Coherence Tomography, from bench to bedside: shining the light during percutaneous vascular intervention
Full text linkCombination between mean platelet volume and platelet distribution width to predict the prevalence and extent of coronary artery disease: results from a large cohort study
No full textShort-term effects of aspirin and clopidogrel on mean platelet volume among patients with acute coronary syndromes. A single-center prospective study.
No full textLong-term follow-up of DDDR closed-loop cardiac pacing for the prevention of recurrent vasovagal syncope
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Optical coherence tomography for guidance of treatment of in-stent restenosis with cutting balloons.
No full textSilent double aortic arch coincidentally found during cardiac catheterization in elderly man
No full textHaemoglobin levels do not correlate with the extent of coronary artery disease: results from a large cohort study.
No full textOBJECTIVES: Even though anaemia has been shown to be a risk factor for adverse cardiovascular disease, there is scarce evidence of its relationship with angiographically proven coronary artery disease (CAD). The aim of this study was to evaluate the relationship between haemoglobin(Hb) levels and the extent of CAD.
MATERIALS AND METHODS: We measured Hb, mean corpuscular volume and red blood cell count in 2363 consecutive patients undergoing coronary angiography. Patients were divided into four groups according to quartile values of Hb (≤12.2 g/dl, group 1; 12.3-13.5 g/dl, group 2; 13.6-14.6 g/dl, group 3; >14.6 g/dl, group 4).
RESULTS: Patients with lower Hb were older (P<0.001), there was a predominance of women (P<0.0001), and patients had diabetes (P<0.0001), hypertension (P=0.024), renal failure (P<0.0001), previous coronary artery bypass graft (P<0.0001), previous cerebrovascular accident (P=0.039) and platelet count (P<0.0001). In terms of angiographic features, low Hb levels were associated with a larger prevalence of calcified lesions (P<0.001), but a lower prevalence of thrombus-containing lesions (P<0.001). Hb was not associated with the prevalence of CAD [odds ratio (OR) (95% confidence interval (CI))=0.96 (0.89-1.04), P=0.35], whereas an association was observed with the severity of CAD [OR (95% CI)=0.92 (0.85-0.99), P=0.032] that was not confirmed after correction for baseline confounding factors [OR (95% CI)=0.98 (0.89-1.09), P=0.76]. Similar findings were observed for mean corpuscular volume and red blood cell count.
CONCLUSION: This study showed that Hb levels are not associated with the prevalence and extent of CAD
Uric acid does not affect the prevalence and extent of coronary artery disease. Results from a prospective study
No full textFractional flow reserve evaluation and chronic kidney disease: Analysis from a multicenter Italian registry (the FREAK study)
No full textObjectives: To establish if the presence of chronic kidney disease (CKD) influences fractional flow reserve (FFR) value in patients with intermediate coronary stenosis. Background: FFR-guided coronary revascularization reduces cardiac adverse events in patients with coronary artery disease. CKD impairs microcirculation and increases cardiovascular risk. Whether CKD presence may limit FFR accuracy is unknown. Methods: We used data from a multicenter prospective registry enrolling 1.004 patients undergoing FFR evaluation for intermediate stenosis. We assessed the relationship between clinical and angiographic variables and FFR measurement. CKD was defined as CrCl value ≤45 ml/min. FFR value was considered potentially flow-limiting, and therefore positive, if ≤0.80. The index of microcirculatory resistance (IMR) was calculated in 20 patients stratified according CrCl value (single-center substudy). Results: FFR measurement was positive in 395 (39%) patients. Overall, 131 (13%) patients had CKD. Patients with CrCl ≤45 ml/min showed significantly higher FFR values as compared to the others (0.84±0.07 vs. 0.81±0.08, p<0.001). Positive FFR occurrence was lower in patients with CrCl ≤45 ml/min (27% vs. 41%, p<0.01). After multivariable analysis, diabetes (HR 1.07, 95%CI 1.008-1.13, p=0.03), left anterior descending (HR 1.35, 95%CI 1.27-1.43, p<0.001) and CrCl ≤45 ml/min (HR 0.92, 95%CI 0.87-0.97, p=0.005) emerged as independent predictors of FFR measurement. Accordingly, IMR values were higher in patients with CrCl ≤45 ml/min (32 U [28245] vs. 16 U [11220], p<0.01). Conclusions: FFR and IMR measurements differ between CKD patients and those with normal renal function. Flow-limiting FFR is less frequent in patients with CrCl ≤45 ml/min
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