104,342 research outputs found
La querelle des corps. Acceptions et pratiques dans la formation des societes europeennes
No full textIntroduzione al fascicolo curato da Calvi G., Sebastiani S
Pia Sebastiani, piano (Argentina)
No full textConcierto interpretado por Pia Sebastiani. Esta pianista y compositora nació en Buenos Aires, donde estudió con la orientación de los maestros Lalewicz, Gilardi y Baldi. Merced a los numerosos premios y becas nacionales y extranjeros obtenidos en el comienzo de su carrera, viajó más tarde a Europa y los Estados Unidos, donde se perfeccionó con los maestros Marquerite Long, Magda Tagliaferro, Olivier Messiaen, Darius Milhaud y Aaron Copland. Así, esta artista egresó del Conservatorio Nacional de París y del "Berhshire Music Center" (Tanglewood). Desde entonces realizó ininterrumpidamente giras por los más importantes centros musicales de Europa, Latinoamérica y los Estados Unidos.
En este concierto interpretó obras de D. Scarlatti, J. Brahms, C. Debussy, G. Faure y A. Ginastera
Sebastiani (N.), Summarium Theologiœ moralis.
No full textG. V. Sebastiani (N.), Summarium Theologiœ moralis.. In: Échos d'Orient, tome 21, n°126, 1922. p. 255
G-protein coupled receptors (GPCRs) in the treatment of diabetes: Current view and future perspectives
No full textG-protein coupled receptors (GPCRs) represent the largest receptor family in the genome and are of great interest for the design of novel drugs in a wide variety of diseases including neurologic disorders, obesity and Type 2 diabetes mellitus. The latter is a chronic disease characterized by insulin resistance and impaired insulin secretion, affecting >400 million patients worldwide. Here we provide an overview on: a) The molecular basis of GPCR signalling and of its involvement in the regulation of insulin secretion and of glucose homeostasis; b) the role of GPCRs in type 2 diabetes pathophysiology and as therapeutic targets of current and future glucose-lowering drugs
Neurotrophic keratitis: current challenges and future prospects
No full textPiera Versura, Giuseppe Giannaccare, Marco Pellegrini, Stefano Sebastiani, Emilio C Campos Ophthalmology Unit, Department of Experimental, Diagnostic and Specialty Medicine (DIMES), Alma Mater Studiorum University of Bologna, Sant’Orsola-Malpighi Teaching Hospital, Bologna, Italy Abstract: Neurotrophic keratitis (NK) is a degenerative corneal disease caused by damage of trigeminal corneal innervation, which leads to spontaneous epithelial breakdown and corneal ulceration. The impairment of corneal sensory innervation causes the reduction of both protective reflexes and trophic neuromodulators that are essential for the vitality, metabolism, and wound healing of ocular surface tissues. A wide range of ocular and systemic conditions, including herpetic keratitis, ocular chemical burns, corneal surgery, diabetes, multiple sclerosis, and neurosurgical procedures, can cause NK by damaging trigeminal innervation. Diagnosis of NK requires careful investigation of any ocular and systemic condition associated with the disease, complete ocular surface examination, and quantitative measurement of corneal sensitivity. The clinical stages of NK range from corneal epithelial alterations (stage 1) to persistent epithelial defect (stage 2) and ulcer (stage 3), which may progress to corneal perforation. Management of NK is based on clinical severity, and the aim of the therapy is to halt the progression of corneal damage and promote epithelial healing. Although several medical and surgical treatments have been proposed, no therapies are currently available to restore corneal sensitivity, and thus, NK remains difficult and challenging to treat. The purpose of this review is to summarize available evidence on the pathogenesis, diagnosis, and treatment of NK. Novel medical and surgical therapies including the topical administration of nerve growth factor and corneal neurotization are also described. Keywords: neurotrophic keratitis, neurotrophic corneal ulcer, corneal nerve
Supplementary material 1 from: Astuti G, Roma-Marzio F, D'Antraccoli M, Bedini G, Carta A, Sebastiani F, Bruschi P, Peruzzi L (2017) Conservation biology of the last Italian population of Cistus laurifolius (Cistaceae): demographic structure, reproductive success and population genetics. Nature Conservation 22: 169-190. https://doi.org/10.3897/natureconservation.22.19809
No full textSupplementary material 1 from: Astuti G, Roma-Marzio F, D'Antraccoli M, Bedini G, Carta A, Sebastiani F, Bruschi P, Peruzzi L (2017) Conservation biology of the last Italian population of Cistus laurifolius (Cistaceae): demographic structure, reproductive success and population genetics. Nature Conservation 22: 169-190. https://doi.org/10.3897/natureconservation.22.1980
Supplementary material 3 from: Astuti G, Roma-Marzio F, D'Antraccoli M, Bedini G, Carta A, Sebastiani F, Bruschi P, Peruzzi L (2017) Conservation biology of the last Italian population of Cistus laurifolius (Cistaceae): demographic structure, reproductive success and population genetics. Nature Conservation 22: 169-190. https://doi.org/10.3897/natureconservation.22.19809
No full textSupplementary material 3 from: Astuti G, Roma-Marzio F, D'Antraccoli M, Bedini G, Carta A, Sebastiani F, Bruschi P, Peruzzi L (2017) Conservation biology of the last Italian population of Cistus laurifolius (Cistaceae): demographic structure, reproductive success and population genetics. Nature Conservation 22: 169-190. https://doi.org/10.3897/natureconservation.22.1980
Blue-jeans
No full textStudio della comparsa e della simbologia dei blue-jeans nella letteratura italiana dal dopoguerra a oggi, con particolare attenzione alle difficoltà grafiche nell’uso del prestito, poi non adattato
Supplementary material 2 from: Astuti G, Roma-Marzio F, D'Antraccoli M, Bedini G, Carta A, Sebastiani F, Bruschi P, Peruzzi L (2017) Conservation biology of the last Italian population of Cistus laurifolius (Cistaceae): demographic structure, reproductive success and population genetics. Nature Conservation 22: 169-190. https://doi.org/10.3897/natureconservation.22.19809
No full textSupplementary material 2 from: Astuti G, Roma-Marzio F, D'Antraccoli M, Bedini G, Carta A, Sebastiani F, Bruschi P, Peruzzi L (2017) Conservation biology of the last Italian population of Cistus laurifolius (Cistaceae): demographic structure, reproductive success and population genetics. Nature Conservation 22: 169-190. https://doi.org/10.3897/natureconservation.22.1980
The transcription factor Foxm1 controls pro-stemness microRNAs in cerebellar neural stem cells (NSCs)
No full textBackground: Cerebellar neural stem cells (NSCs) maintenance is of great interest since NSCs can be used to treat impaired cells and tissues or improve regenerative power of degenerating cells in neurodegenerative diseases or spinal cord injuries. Under maintenance conditions, NSCs express a number of Hedgehog-Gli (Hh-Gli) linked and stemness genes (e.g. Nanog, Oct4, Sox2) whose mechanisms of regulation have been under investigation. However, the interplay between transcription factors and microRNAs in NSCs is still being charted.
Aim: Identification of new molecular players involved in NSCs’ maintenance with particular interest in the major regulatory pathway Hedgehog-Gli.
Materials and Methods: Cells used for the study were NSCs isolated from postnatal day 4 (P4) wild type (C57BL/6) mice cultured both as neurospheres in selective medium and as differentiated NSCs when cultured in medium with serum. NSCs and their differentiated counterparts were analysed by high-throughput technologies. Bioinformatics analysis was used for the identification of the Foxm1-regulated miRNAs; knock-down experiments and clonogenic assays were used for functional studies. Chromatin immunoprecipitation experiments (ChIP) were used to investigate the binding between Foxm1 and its targets and between Foxm1 and its regulators.
Results: NSCs and their differentiated counterparts were analysed using next-generation mRNA- and miRNA-sequencing. The transcriptional analysis allowed the identification of Foxm1 as one of the highest transcripts in NSCs and the miRNA-sequencing provided a number of highly expressed miRNAs. The use of bioinformatics analysis resulted in the Foxm1-regulated miRNAs, miR-15 ~ 16 cluster, miR-17 ~ 92 cluster, miR- 130b and miR-301a. Functional experiments, such as knock-down experiments and clonogenic assays enabled the identification of Foxm1 as a downstream mediator of the Hh-Gli signalling and with the ability to regulate the above mention miRNAs.
Conclusion: The study presented reveals a new Foxm1-microRNAs network with a major role in the maintenance of NSCs. These results add a previously unidentified important molecular aspect that could be used in future neurodegenerative disease studies, thus enriching the field of translational medicine
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