1,721,231 research outputs found
Role of technetium-99m tetrofosmin SPECT imaging in the examination of patients with breast lesions
No full textFeasibility study of a computer-assisted radioguided surgery system
No full textThis paper deals with the study of a system prototype that can be used as an auxiliary tool in radioguided surgery methods. The use of new technologies in radioguided surgery concern the exact positioning of the lesion to be exerted. This is possible, in operation theatre, thanks to portable scintigraphics devices or to radiation counters. Due to lack of a coordinate system in the operation field, it is difficult for the surgeon to localize the pathology after removing the detection instrument. The system proposed in this paper is composed mainly of three elements: a handheld, high-resolution gamma camera with a small Field Of View (FOV) based on Hamamatsu R8900-00-C12 Position Sensitive Photomultiplier Tube (PSPMT), a laser scanner for the reconstruction of the body district and a stereoscopic system for contactless surgical tool tracking. Analyzing a set of scintigraphic images, taken from different projections, it is possible to localize the three-dimensional position of the lesion. Thanks to the use of the scanner and image fusion techniques, the pathology is shown on a PC monitor correctly positioned with respect to the body surface. Using a couple of stereoscopic cameras, the surgical tool can be tracked and shown on the same monitor, so that the surgeon can know the instantaneous relative position between the tool and the pathology. Exploiting these systems, a navigation system prototype has been developed that is suitable for radioguided surgical application. (c) 2007 Elsevier B.V. All rights reserved
Sentinel node biopsy
No full textKrag et al. (Oct. 1 issue)1 present interesting data on the use of probe-guided resection of radioactive sentinel nodes in patients with breast cancer, but they conclude that “the procedure can be technically challenging, and the success rate varies according to the surgeon.” In our opinion, preoperative lymphoscintigraphy can facilitate surgical localization and excision of the sentinel node and increase the detection rate.
Lymphoscintigraphy is a nuclear-medicine procedure that is easy to perform and, in conjunction with the intraoperative gamma probe, has been successfully used primarily in patients with malignant melanoma or breast cancer.2,3 The main advantage of this imaging technique is that it allows accurate preoperative localization of the sentinel node; after scintigraphic images have been obtained, a mark can be made on the skin that corresponds to the first lymph node detected by the gamma camera, thereby indicating precisely where the incision should be made. The use of the gamma probe during surgery then guides dissection, making the node biopsy easier and consistently successful. In most patients, the sentinel node is visible within 30 minutes after the injection, regardless of the size of the radiolabeled particles used, when they are injected subdermally.4 Lymphoscintigraphy is not time-consuming; anterior and lateral views, each obtained within five minutes, are sufficient to identify another 10 percent of sentinel nodes that might have not been detected with the use of a probe survey alone.
Indium-111 pentetreotide scintigrapy in the detection of insulinomas: importance of SPECT imaging
No full textJ Nucl Med. 2000 Mar;41(3):459-62.
111In-pentetreotide scintigraphy in the detection of insulinomas: importance of SPECT imaging.
Schillaci O, Massa R, Scopinaro F.
SourceDepartment of Sciences and Biomedical Technologies, University of L'Aquila, Rome, Italy.
Abstract
The aim of this study was to determine whether the systematic use of SPECT can increase the reported low sensitivity of somatostatin receptor scintigraphy (SRS) in detecting insulinomas.
METHODS: Fourteen patients were evaluated. After 111In-pentetreotide injection (approximately 250 MBq intravenously), abdominal SPECT images were obtained at 4 h and multiple planar images were obtained at 4 and 24 h. MRI and CT were performed within 1 mo of SRS. Sixteen tumors were histologically verified after surgery in 14 patients.
RESULTS: SPECT revealed 14 lesions in 12 patients (sensitivity, 87.5%), both planar SRS and MRI revealed 7 tumors in 7 patients (sensitivity, 43.8%), and CT revealed only 5 lesions in 4 patients (sensitivity, 31.3%). Moreover, in 4 patients SPECT was the only examination with positive findings.
CONCLUSION: SPECT at 4 h is mandatory for preoperative detection of insulinomas using SRS because the images are more sensitive than planar images and are superior to images from other conventional methods.
PMID:10716319[PubMed - indexed for MEDLINE] Free full tex
Anticorpi monoclonali anti-galectina-3 marcati per visualizzazione e radio ablazione in vivo di tumori galectina-3 positivi
No full text“Boom-Boom” radioimmunotherapy of lymphomas. Are two magic bullets better than one?
No full textThis is a commentarz on the use of radioimmunotherapy with Zevalin in the management of lymphomas
- …
