1,720,990 research outputs found
Co-soltrim (lidaprim): microbiological evaluation vs.co-trimoxazole
No full textCosoltrim (CTM) is the generic name suggested for the new combination of sulfametrole (SMT) (3-methoxy-44(4 amino-benzene-sulfonamide)-1,2,5-thiodazoleeee) with trimethoprim (TMP)in the 1:5 ratio (LIDAPRIM Farmades S.p.A. Roma, Italy). We have studied the antibacterial activity in vitro of SMT-CTM and of cotrimoxazole (CTZ) as a standard drug, on 99 strains of Gram-positive and Gram-negative bacteria which have been recently isolated from hospitalized patients.We also have carried out an in vivo study, by comparing the antibacterial activity(PD50) in mice of CMT with that of CTZ: In vitro, the CTM antibacterial activity appears slightly superior to that of CTZ on E. coli , and Propeus spp. and Providencia spp.:The study on the in vivo activity has been carried out by infecting mice with: Proteus mirabilis CH/1, Salmonella parathyphi.ASA12.
The bacterial activity seems to be synergic for both application
Activity of kanendomycin and other aminoglycoside antibiotics against various species of Enterobacteriaceae in vitro
No full text
CP-45,899, a beta-lactamase inhibitor: in vitro study alone and combined with ampicillin
No full text[Miocamycin: microbiological features].
No full textMacrolides are antibiotics with high tolerability and wide activity spectrum both against Gram-positive and Gram-negative bacteria and other pathogenic agents: Miocamycin (MOM) belongs to this group. On this basis the antibacterial of the MOM has been proved on a sampling of hospital isolated staphylococci strains in comparison to josamicin and eriytromicin all belonging to the macrolides family and also to lincomycin and clindamicyn which have the same activity spectrum.
Miocamycin compared to other antibiotics proved to be the most active against both methicillin-sensitive and methicillin-resistant strains
ATTIVITA' ANTIBATTERICA ED ANTIFUNGINA DELLA PROPOLI
No full textSamples of wax-removal propolis by a cold working and physic extractive method
*E.P.I.D.® and crude propolis , were investigated for their antibacterial and fungicidal activity against
clinical isolates Gram-positive strains and fungi.
All the samples were active against tested microrganisms .
E.P.I.D® propolis compared with crude propolis, shows a better antimicrobial activity against bacterial
strains with MICs ranging from 0,156 to 1,25 mg/ml and fungi ranging from 0,6-5 mg/ml for
Candida spp. and from 2,5-5 mg/ml against dermathophytes.
Introduzione
La propoli è una sostanza resinosa prodotta dalle api
bottonatrici raccolta da diverse piante, da molto tempo
conosciuta per le sue caratteristiche farmacologiche.
Essa è raccolta dalle api in particolare dall’Apis
mellifera, dai germogli, foglie e cortecce di differenti
piante (betulle, pioppi, olmi etc.) , successivamente
trasformata da enzimi presenti nella saliva.
Viene utilizzata dalle api stesse per restringere l’ingresso
dell’alveare, per chiudere le fessure presenti
nell’arnia e per imbalsamare eventuali insetti predatori
uccisi, dopo un’invasione dell’alveare.
E’ usata come “medicamento alternativo”,in infezioni
otorinolaringoiatriche, in odontoiatria, gastroenterologia,
e in infezioni ginecologiche.
Le proprietà antibatteriche e antifungine della propoli
sono note, ma la sua efficacia è correlata all’origine
geografica, a causa della diversa composizione
chimica dovuta alle diverse piante. (2)
Tra i vari costituenti: cere, resine, balsami, olii essenziali,
acidi aromatici, polline e costituenti polifenolici con predominanza
di composti a struttura flavonoide, aldeidi,
acido benzoico e caffeico sono le più importanti sostanze
riscontrate nella composizione della propoli, la loro
quantità è dipendente dal luogo e dal tempo di raccolta.
Sono sta
Multifactorial aspects of antimicrobial activity of propolis
No full textWe investigated the antibacterial activity of sub-inhibitory concentrations of ethanolic extract of propolis (EEP), and its effect on the antibacterial activity of some antibiotics. Some clinically isolated Gram-positive strains were used. Moreover, sub-inhibitory concentrations of EEP were used to value its action on some important virulence factors like lipase and coagulase enzymes, and on biofilm formation in Staphylococcus aureus. Our results indicated that EEP had a significant antimicrobial activity towards all tested clinical strains. Adding EEP to antibacterial tested drugs, it drastically increased the antimicrobial effect of ampicillin, gentamycin and streptomycin, moderately the one of chloramphenicol, ceftriaxon and vancomycin, while there was no effect with erithromycin. Moreover, our results pointed out an inhibitory action of EEP on tipase activity of 18 Staphytococcus spp. strains and an inhibitory effect on coagulase of 11 S. aureus tested strains. The same EEP concentrations showed a negative interaction with adhesion and consequent biofilm formation in S. aureus ATCC 6538P. (c) 2006 Elsevier GmbH. All rights reserved
- …
