1,721,106 research outputs found
Hyper-immune/convalescent plasma: an old option and a valid strategy for treatment of COVID-19?
No full textCurrently, there are no approved specific antiviral agents for novel coronavirus disease (COVID-19). Hyper-immune/convalescent plasma derived from recently recovered donors seems to be useful to treat COVID-19 patients, an addition to maximal supportive care and antiviral agents. The endpoints are the improvement of clinical symptoms and laboratory parameters of these patients. However, the efficacy of hyper-immune/convalescent plasma treatment for severe infectious diseases is still controversial. The optimal dose and time point, as well as the clinical benefit of hyper-immune/convalescent plasma therapy, needs further investigation in larger well-controlled trials
Atlante di anatomia palpatoria di collo, tronco e arto superiore. Ispezione manuale di superficie. Serge Tixa
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The Role of CTLA-4 Gene Polymorphisms in Autoimmune Disease Pathogenesis: A 2012 Update
No full textGene association studies are very appealing in autoimmune diseases. In recent years, access to other human
gene sequences prompted investigators to focus on genes encoding the immune regulatory proteins such as the costimulatory,
adhesion molecules, cytokines and chemokines and their receptors. Among them, cytotoxic T-lymphocyte
antigen-4 (CTLA-4) has been extensively studied for its pivotal role in autoimmunity. As a central regulatory element of
the immune responses magnitude, CTLA-4 could act as a double-edged sword and only the optimal expression ensures
an effective, but at the same time, safe immune response. Thus, we can argue that CTLA-4 alleles associated with abnormal
membrane expression could make a person more susceptible to tumor growth and/or manifestation of autoimmune
diseases. Unfortunately, the relationship between the presence of SNP conferring susceptibility/protection to autoimmune
disease and the genetic regulation/modification of CTLA-4 is the not yet fully clarified, and in some aspects conflicting
Influenza di alcune cefalosporine sull'eliminazione di diversi plasmodi in Escherichia coli.
No full textEffect of lentiviral vectors on the phenotypical and functional maturation of human dendritic cells: implications for gene therapy.
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Eliminazione di Flac durante saggi in vitro dell'attività antibatterica di diversi antibiotici.
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