65,622 research outputs found
Chronic Idiopathic Constipation in Adults: A Review on Current Guidelines and Emerging Treatment Options
No full textGabrio Bassotti,1 Paolo Usai Satta,2 Massimo Bellini3 1Gastroenterology & Hepatology Section, Department of Medicine and Surgery, University of Perugia, Perugia, Italy; 2Gastrointestinal Unit, “G. Brotzu” Hospital, Cagliari, Italy; 3Gastrointestinal Unit, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, ItalyCorrespondence: Gabrio BassottiClinica di Gastroenterologia ed Epatologia, Ospedale Santa Maria della Misericordia, Piazzale Menghini, 1, San Sisto (Perugia), 06156, ItalyEmail [email protected]: Chronic idiopathic constipation (CIC) is a common functional bowel disorder characterized by difficult, infrequent, and/or incomplete defecation. It has a great impact on the quality of life and on health care system and represents a heavy economic burden. The diagnosis is based on symptoms, classified by the Rome IV criteria. The aim of this review was to evaluate the current therapeutic guidelines for adult CIC and highlight new emerging treatments. In detail, European, French, Spanish and Korean guidelines have been identified and compared. Osmotic laxatives, and in particular polyethylene glycol, represent the first-line therapeutic approach. Stimulant laxatives are recommended as a second-line therapy. Pelvic floor rehabilitation is recommended in patients with ano-rectal dyssynergia. In patients who fail to improve with pharmacological therapies sacral nerve stimulation is considered as last chance before surgery. Surgical approach has however limited indications in selected cases. Inertia coli refractory to any approach and obstructed defecation are two subtypes which can benefit from surgery. Among emerging agents, prucalopride, a prokinetic agent, is recommended as a second-line treatment in refractory CIC patients. In addition, the secretagogues linaclotide and plecanatide and the bile acid transported inhibitor elobixibat can be effective in patients not responsive to a second-line therapeutic regimen, although they are not worldwide commercially available.Keywords: chronic idiopathic constipation, guidelines, osmotic laxatives, pelvic floor rehabilitation, prokinetics, secretagogue
Guida alla Scheda RPM, in RPM - Scheda di rilevazione, progettazione e monitoraggio del benessere del bambino/a e della sua famiglia. Strumento per il progetto quadro
No full textDocumento depositato in http://www.educazione.unipd.it/web/?q=node/175
La traduzione dall’inglese è a cura di Paola Milani, Marco Ius, Sara Serbati.
Il lavoro di adattamento è a cura di Paola Milani, Valerio Belotti, Paola Bastianoni, Marco Ius, Sara Serbati,
Caterina Satta, Federico Zullo, Salvatore Me, Paola Baglioni, Vania Baccin, Michela Castellan, Cristina
Toniolo, Chiara Magrin
Prefix probabilities for linear context-free rewriting systems
No full textWe present a novel method for the computation of prefix probabilities for linear context-free rewriting systems. Our approach streamlines previous procedures to compute prefix probabilities for context-free grammars, synchronous context-free grammars and tree adjoining grammars. In addition, the methodology is general enough to be used for a wider range of problems involving, for example, several prefixes
Computation of distances for regular and context-free probabilistic languages
No full textSeveral mathematical distances between probabilistic languages have been investigated in the literature, motivated by applications in language modeling, computational biology, syntactic pattern matching and machine learning. In most cases, only pairs of probabilistic regular languages were considered. In this paper we extend the previous results to pairs of languages generated by a probabilistic context-free grammar and a probabilistic finite automaton.Peer reviewe
Computation of infix probabilities for probabilistic context-free grammars
No full textThe notion of infix probability has been introduced in the literature as a generalization of the notion of prefix (or initial substring) probability, motivated by applications in speech recognition and word error correction. For the case where a probabilistic context-free grammar is used as language model, methods for the computation of infix probabilities have been presented in the literature, based on various simplifying assumptions. Here we present a solution that applies to the problem in its full generality
Computing partition functions of PCFGs
No full textAcknowledgement provided in erratum at DOI:10.1007/s11168-009-9062-1We investigate the problem of computing the partition function of a probabilistic context-free grammar, and consider a number of applicable methods. Particular attention is devoted to PCFGs that result from the intersection of another PCFG and a finite automaton. We report experiments involving the Wall Street Journal corpus.Peer reviewe
Bacterial cell shape regulation: testing of additional predictions unique to the two-competing-sites model for peptidoglycan assembly and isolation of conditional rod-shaped mutants from some wild-type cocci
No full textThe two-competing-sites model for peptidoglycan assembly for bacterial cell shape regulation suggests that in rods, bacterial cell shape depends on the balance between two reactions (sites), one responsible for lateral wall elongation and the other responsible for septum formation. The two reactions compete with each other so that no lateral wall can be formed during septum formation and vice versa. When the site for lateral wall elongation overcomes that for septum formation, long rods or filaments are formed and cell division may be blocked. When the reaction leading to septum formation is hyperactive compared with the other, coccobacilli or cocci are formed. Other bacteria carry only one site for peptidoglycan assembly and can grow only as cocci. The two-competing-sites model predicts that two different types of cocci exist (among both morphology mutants and wild-type strains); one carries only the site for septum formation, whereas the other also carries the site for lateral wall elongation, the former site predominating over the latter. As a consequence of the inhibition (by antibiotics or by mutations) of septum formation in wild-type cocci of various species and in coccoid morphology mutants, some cocci are expected to undergo transition to rod shape and others are not. We have evaluated these predictions and show that they are in agreement. In fact, we found that among wild-type cocci belonging to 13 species, those of 6 species formed rods, whereas the remaining organisms maintained their coccal shape when septa were inhibited by antibiotics. Some coccoid morphology mutants of rod-shaped bacteria underwent coccus-to-rod transition after septum inhibition by antibiotics, whereas others maintained their coccal shape. When a mutation that causes septum inhibition was expressed in a morphology mutant of Klebsiella pneumoniae grown as a coccus, transition to rod shape was observed. A total of 914 mutants unable to form colonies at 42 degrees C were isolated from the coccoid species mentioned above. Between 75 and 95% of the mutants isolated from the species that formed rods when septum formation was inhibited by antibiotics but none of those isolated from the others underwent coccus-to-rod transition upon incubation at the nonpermissive temperature
Plecanatide for the treatment of chronic idiopathic constipation in adult patients
No full textIntroduction. Chronic idiopathic constipation (CIC) is a functional gastrointestinal disorder that is associated with an increased healthcare cost and an abnormally poor quality of life. Plecanatide is a natural analog to the peptide agonist of the guanylate cyclase-C (GC-C) receptor, uroguanylin. The conversion of guanosine 5-triphosphate to cyclic guanosine monophosphate results in an increased bowel fluid secretion. Plecanatide is a promising new agent for CIC unresponsive to current therapeutic regimes.Areas covered. A comprehensive online search of Medline and the Science Citation Index was made using the keywords 'plecanatide', 'guanylate cyclase-C agonists', and 'constipation', in various combinations. We reviewed the pharmacodynamics, pharmacokinetics, and metabolism of this agent, and the most significant studies regarding the clinical efficacy and safety of plecanatide in CIC therapy.Expert opinion. Experimental studies showed that plecanatide was significantly better than placebo in reducing CIC severity, straining, stool consistency, bowel movements and quality of life. Apart from limited cases of diarrhea, no serious adverse events were reported. However, few data are available on its long-term safety. Furthermore, patients' affordability of plecanatide can be limited by its costs. Finally, this new agent with a different way of action can be proposed in patients refractory to common therapy
La donna che "non esiste". Rappresentazioni del femminile nell'opera giuridico-letteraria di Salvatore Satta
No full textThe aim of this essay is to explore Salvatore Satta's work, with a special focus on the female characters which appear in his novels. Through Kafka and Benjamin's vision of the law mythical trait, the article analyses the masterpiece “Il giorno del giudizio” showing how Satta presents gender discrimination in the Sardinian cultural imagery. The narrative of the female figures and of their “guilt” of existence offers the same idea of law as life and life as judgment (i.e. as trial) which is typical of Satta’s thought
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