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QUANTITATIVE EEG AND RCBF BIDIMENSIONAL MAPS: METHODOLOGY AND APPLICATION IN PHARMACO- ELECTROENCEPHALOGRAPHY.
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Quantitative EEG effects and drug plasma concentration of phenobarbital, 50 and 100 mg single-dose oral administration to healthy volunteers: evidence of early CNS bioavailability.
No full textSingle, 50- and 100-mg oral doses of phenobarbital and a matching placebo were administered double-blind to 8 young, healthy male subjects. Multilead electroencephalographic (EEG) samples were recorded prior to, and at regular intervals within the 2 h following administration. The EEG signal was processed by power spectral analysis; the drug plasma concentration was assessed concomitantly. Plasma peaks after the 50- and 100-mg dose were, respectively, 3.38 +/- 1.29 and 4.09 +/- 1.24 micrograms/ml. Despite the low drug plasma concentration, a systematic power increment of the EEG fast frequency spectral segments occurred at either dose on the anterior scalp areas from the 30- or 60-min postdrug control onward, and was preponderant on central electrodes; a significant correlation (Kendal's coefficient for ranked data) with the drug plasma concentration was observed limitedly to the anterior scalp areas. No correlation with plasma levels was observed for unsystematic EEG variations
Magnetic oscillatory components of Human Flash-VEP: Luminance and eccentricity functions and effect of acute scopolamine
No full textComputerized EEG analysis for studying the effect of drugs on the central nervous system.
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Cutaneous antihistaminic action of cetirizine and dose-related EEG concomitants of sedation in man.
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