163,075 research outputs found
Sandell, J M, VX27806
No full textThis record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/415214Surname: SANDELL. Given Name(s) or Initials: J M. Military Service Number or Last Known Location: VX27806. Missing, Wounded and Prisoner of War Enquiry Card Index Number: 15884.235636
Item: [2016.0049.47475] "Sandell, J M, VX27806
Sandell, D J, 423334
No full textThis record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/415213Surname: SANDELL. Given Name(s) or Initials: D J. Military Service Number or Last Known Location: 423334. Missing, Wounded and Prisoner of War Enquiry Card Index Number: 55506.235635
Item: [2016.0049.47474] "Sandell, D J, 423334
[Report to Chief J. E. Curry, by an unknown author #1]
No full textReport to Chief J. E. Curry, by an unknown author. The report contains a list of officers who gave depositions to the United States Attorney
[Report to Chief J. E. Curry, by an unknown author #2]
No full textReport to Chief J. E. Curry, by an unknown author. The report contains a list of officers who gave depositions to the United States Attorney
Multicultural Education in American Pedagogical Universities
No full textPresentation at the Russian Academy of Education\u27s Institute of Pedagogy Development Strategy, Moscow, RU, April 13, 2016.
Video is in Russian and English and includes multiple speakers in addition to Dr. Sandell
How to Submit Manuscripts for Publication in US Scholarly Journals
No full textPresentation at the Russian Academy of Education\u27s Institute of Pedagogy Development Strategy, Moscow, RU, April 12, 2016.
Video is in Russian and English and includes multiple speakers in addition to Dr. Sandell
Development of radioligands for the serotonergic neurotransmission system for use in positron emission tomography
No full textThe serotonergic system is implicated in several neuropsychiatric disorders, such as depression, anxiety and schizophrenia. Several hypotheses on the pathophysiology of these disorders are based on the pharmacology of serotonergic drugs. Selective serotonin reuptake inhibitors (SSRIs) are widely used for the treatment of depression and anxiety. Serotonin 5HT1A receptor agonists and antagonists are currently explored as potential anxiolytics and antidepressants. The brain imaging technique Positron Emission Tomography (PET) allows quantitative studies of neuroreceptor binding and receptor occupancy in relation to clinical drug treatment and drug development. A prerequisite is the availability of suitable radioligands.The main objective of this thesis was to develop new radioligands for PET examinations of the 5-HT1A receptor and the serotonin transporter (5-HTT) in the human brain.Radiolabeling was performed with the radionuclides carbon-11, fluorine-18, iodine-125 and tritium. The radioligands were characterized in vitro on rat brain homogenates or with autoradiography on post-mortem human brain cryosections. The in vivo brain distribution of radioactivity was measured in the cynomolgus monkey brain with PET after i.v. injection of the radioligands.[Carbonyl-11C]WAY-100635 is established as a reference radioligand for in vivo imaging of the 5-HT1A receptor and is thus a suitable lead compound for the development of new radioligands with improved properties such as being less prone to metabolism and to be labeled with alternative radionuclides. Halogenated analogues of WAY-100635 were examined with autoradiography and PET. After injection of [11C]6FPWAY, the target to nontarget ratios were high. The specific binding could be inhibited by pretreatment with unlabeled WAY-100635. The early peak equilibrium and the high brain uptake makes [11C]6FPWAY a potential PET radioligand for the 5-HT1A receptor in man.NAD-299, a recently developed selective 5-HT1A receptor antagonist was labeled with carbon11. Autoradiography demonstrated accumulation of radioactivity in accordance with the known distribution of 5-HT1A receptors. The accumulation of radioactivity in 5-HT1A rich regions was completely inhibited by coincubation with known 5-HT1A receptor antagonists and agonists, thus demonstrating the specificity and selectivity of [11C]NAD-299 binding to 5 HT1A receptors. Furthermore, high target to non-target ratios and early peak equilibrium was recorded with PET. The results motivate further investigation of [11C]NAD-299 as a potential PET radioligand for quantitative studies of 5-HT1A receptors in man.A series of six phenyltropane analogues with various affinity for the 5-HTT were labeled with carbon-11. One of these, [11C]RTI-357, accumulated in 5-HTT rich regions of the monkey brain. Pretreatment with the selective 5-HTT inhibitor citalopram. indicated that [1 1C]RTI-357 binds specifically to the 5-HTT.5-methyl-6-nitroquipazine (MNQP), a methylated analogue of the potent 5-HTT inhibitor 6- nitroquipazine was synthesized and radiolabeled with tritium or carbon-11. [3H]MNQP was found to have subnanomolar affinity for the 5-HTT in the rodent brain. High accumulation of radioactivity in 5-HTT rich regions was recorded with PET after injection of [11C]MNQP. The uptake could be reduced by pretreatment with citalopram. Although a promising radioligand for studies of the 5-HTT in vitro, the slow kinetics and moderate ratios recorded in vivo, may limit its use for quantitative studies of the 5-HTT with PET.List of scientific papersI. Sandell J, Halldin C, Pike VW, Chou Y, Varnas K, Hall H, Marchais S, Nowicki B, Wikstrom HV, Swahn C, Farde L (2001). "New halogenated [11C]WAY analogues, [11C]6FPWAY and [11C]6BPWAY- Radiosynthesis and assessment as radioligands for the study of brain 5-HT1A receptors in living monkey." Nucl Med Biol 28(2): 177-85 https://pubmed.ncbi.nlm.nih.gov/11295428II. Sandell J, Halldin C, Hall H, Thorberg SO, Werner T, Sohn D, Sedvall G, Farde L (1999). "Radiosynthesis and autoradiographic evaluation of [11C]NAD-299, a radioligand for visualization of the 5-HT1A receptor. " Nucl Med Biol 26(2): 159-64 https://pubmed.ncbi.nlm.nih.gov/10100214III. Sandell J, Halldin C, Chou YH, Swahn CG, Thorberg SO, Farde L (2000). "PET examination and metabolism in monkey of [11C]NAD-299, a radioligand for the 5-HT1A receptor." Nucl Med Biol (Accepted)IV. Helfenbein J, Sandell J, Halldin C, Chalon S, Emond P, Okubo Y, Chou YH, Frangin Y, Douziech L, Gareau L, Swahn CG, Besnard JC, Farde L, Guilloteau D (1999). "PET examination of three potent cocaine derivatives as specific radioligands for the serotonin transporter. " Nucl Med Biol 26(5): 491-9 https://pubmed.ncbi.nlm.nih.gov/10473187V. Sandell J, Halldin C, Helfenbein J, Chou YH, Emond P, Swahn CG, Guilloteau D, Farde L (2000). "Synthesis of [11C]2beta-carbomethoxy-3beta-(3-iodo-4-methyl,-ethyl and-isopropyl phenyl)nortropane as potential radiotracers for examination of the serotonin transporter with positron tomography." J Lab Compds Radiopharm 43: 1033VI. Sandell J, Meixiang Y, Chalon S, Emond P, Vercouillie J, Nagren K, Guilloteau D, Halldin C (2000). "Synthesis, radiolabeling and preliminary biological evaluation of 5-methyl-6-nitroquipazine, a potential radioligand for the serotonin transporter." Bioorg Med Chem Lett (Submitted)VII. Sandell J, Halldin C, Sovago J, Chou YH, Gulyas B, Yu M, Emond P, Nagren K, Guilloteau D, Farde L (2001). "PET examination of [11C]5-methyl-6-nitroquipqzine, a radioligand for visualization of the serotonin transporter." (Manuscript)</p
Minimally invasive catheter-based technologies
No full textA simple incision procedure in a blood vessel makes the entire vascular system accessible. Through contrast injection and X-ray visualization, the vascular tree can be mapped and navigated through manual manipulation of thin tubes and wires. This utilization of the vasculature as internal pathways is commonly referred to as the endovascular technique. This technique can be used to deliver implants and drugs, retrieve problematic lesions or objects from the vasculature, or take tissue samples. Compared to open surgery, the advantage of this technique lies in the reduced invasiveness, ideally only leaving a small incision scar at the point of entry. Some interventions, however, are still associated with certain risks, requiring medication or complicating further interventions. The development of sequencing technologies presents an opportunity to improve and miniaturize devices, reducing invasiveness. This thesis aims to mitigate these risks and capitalize on the potential of next-generation sequencing through microfabrication technologies, producing devices that are less invasive than current methods or that enable a new procedure.Initially, the aspect of endovascular heart biopsy is covered. The first work presents the fabrication and in vivo evaluation of a nitinol-based catheter device designed for extracting myocardial tissue. The device is fabricated through picosecond laser machining of nitinol tubes and wires, producing a device that is substantially smaller than what is currently used. The samples are evaluated and compared to samples extracted with conventional devices through RNA-Sequencing, verifying the proof of concept. The second work further emphasizes the device's functionality by evaluating it in a disease model of endomyocardial infarction. Tissue that is affected by the infarct and surrounding healthy tissue is extracted and compared in terms of its genetic expression. This comparison reveals a genetic discrepancy between the sick and healthy tissue, verifying the potential of using the device with RNA-sequencing for diagnostic purposes. The third work evaluates the safety aspects of the novel device in a head-to-head comparison with a conventional device. The study reveals a clear benefit of using the smaller device in terms of the complication rate during the procedure.The fourth work presents the fabrication and in vivo evaluation of another nitinol-based catheter device designed for endothelial cell sampling. The device is fabricated through two-photon polymerization technologies, producing sub-mm brush structures mounted on a nitinol wire. Currently, there are no devices in clinical use that are capable of exclusively extracting endothelial cells. The novel device presents a solution for selective interaction with the innermost layer of the blood vessel. It represents an important step toward sampling endothelial cells for diagnostic and research purposes.The fifth and sixth works collectively present two different aspects of a third nitinol-based catheter device designed to sample tissue from soft organs anywhere in the body. The device is fabricated using laser micromachining, grinding, and two-photon polymerization. The work is separated in terms of the in vivo evaluation and the technical solution. The technical aspects of the device are examined in terms of force generation in miniaturized catheter systems and the problems that arise in terms of mechanical scaling. These problems are solved by attaching pistons along the wire surface coupled with applied pressure to increase the force generated. The sampling with this device is realized, similar to the fourth work, with sub-mm brushes mounted on the wire. In vivo evaluation of this device reveals successful sampling of minute tissue quantities from the liver and kidney, in the size range of 10-100 cells per sample.The seventh work presents the in vivo and in vitro performance of a nanostructure coating on nitinol-based stents. Patients with a stent implant are prescribed an extensive medication regimen to counteract the metal implant's effects on the blood and surrounding tissue. This issue is being continuously targeted by new stent platforms, either with a drug-eluting polymer layer or by being resorbable by the body or through various other means. These implants all have a transient behavior, resulting in different issues over time. Paper VII presents an alternative approach to this problem by instead applying a nanostructure coating that is designed to interact with the blood to a much lesser degree, as demonstrated by CT-angiography and the measurement of multiple biomarkers.List of scientific papersI. Myocardial micro-biopsy procedure for molecular characterization with increased precision and reduced trauma. R. Grankvist, A. Chireh, M. Sandell, A. K. Mukarram, N. Jaff, I. Berggren, H. Persson, C. Linde, F. Arnberg, J. Lundberg, M. Ugander, G. La Manno, S. Jonsson, C. O. Daub & S. Holmin. Scientific Reports. 10, 8029, 2020. https://doi.org/10.1038/s41598-020-64900-w II. Micro-biopsy for detection of gene expression changes in ischemic swine myocardium: A pilot study. A. Chireh, R. Grankvist, M. Sandell, A. K. Mukarram, F. Arnberg, J. Lundberg, C. O. Daub, and S. Holmin. PLOS ONE. 16(4): e0250582. 2021. https://doi.org/10.1371/journal.pone.0250582 III. Safety evaluation of high-risk myocardial micro-biopsy in a swine model. A. Chireh, M. Sandell, R. Grankvist, V. Lövljung, J. Al-Saadi, F. Arnberg, J. Lundberg, M. Settergren, and S. Holmin. Heart and Vessels. 37, 697–704, 2022. https://doi.org/10.1007/s00380-021-01995-9 IV. Endovascular Device for Endothelial Cell Sampling. M. Sandell, A. Chireh, A. Spyrou, R. Grankvist, J. Al-Saadi, S. Jonsson, W. van der Wijngaart, G. Stemme, S. Holmin, and N. Roxhed. Advanced NanoBiomed Research. 2: 2200023, 2022. https://doi.org/10.1002/anbr.202200023 V. Sampling through a transvascular working channel. M. Sandell, A. Chireh, A. Spyrou, J. Al-Saadi, S. Jonsson, W. van der Wijngaart, G. Stemme, N. Roxhed, and S. Holmin. [Manuscript]VI. Hydraulic micropistons enable high force operations through miniaturized catheters. M. Sandell, S. Jonsson, W. van der Wijngaart, G. Stemme, S. Holmin and N. Roxhed. [Submitted]VII. A novel noble metal stent coating reduces in vitro platelet activation and acute in vivo thrombosis formation: a blinded study. M. Sandell, A. Ericsson, J. Al-Saadi, B. Södervall, E. Södergren, S. Grass, J. Sanchez, and S. Holmin. [Submitted]</p
Undergraduate Research Projects: Step-by-Step
No full textThis book is in a workbook format, intended to complement any individual or group of undergraduate researchers in their social science investigations. The step-by-step approach provides understanding and experience with scholarly inquiry. Students discover content and practice skills related to scholarly inquiry and their academic subjects.https://cornerstone.lib.mnsu.edu/books-sandell-undergraduate-research/1000/thumbnail.jp
Murder on the mountain: author talk with Peter J. Wosh
No full textAuthor talk by Peter J. Wosh on May 5th, 2022, on his book, "Murder on the Mountain: crime, passion, and punishment in gilded age New Jersey.
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