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VALUTAZIONE STRUMENTALE E CLINICA DEL SINTROPIO BROMURO (VAL 480), NUOVO SPASMOLITICO DI SINTESI
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Valutazione clinica, endoscopica e funzionale delle anastomosi colo-rettali con suturatrice americana EEA
No full textBlood sample contamination by glucose-containing solutions: effects and identification.
No full textBlood sample contamination by glucose-containing solutions: effects and identification
Sindrome ipercalcemica grave da iperparatiroidismo ectopico in corso di carcinoma broncogeno. Bilobectomia e guarigione
No full textSplenic abscess: the rationale for selective non-surgical treatment.
No full textAbscess of the spleen is a potentially lethal condition, with an associated
mortality rate of 60-100% in untreated patients. Splenectomy, or in selected
cases, surgical or percutaneous drainage of the abscess is currently considered
the standard of care. So far, conservative treatment with antibiotics has been
successfully employed in four patients, including the two reported herein. The
importance of a careful clinical and ultrasonographic monitoring for best
therapeutic decision-making in patients with splenic abscess, is stressed
Influence of spurious hemolysis on blood gas analysis.
No full textBackground: Although the prevalence of hemolyzed samples referred for blood gas analysis is as high as 4%, no studies have assessed the bias introduced by spurious erythrocyte breakdown, nor it is known which parameters are mostly influenced and to what extent. This study was hence planned to assess the influence of spurious hemolysis on venous blood gas analysis. Methods: Venous blood was collected from nine healthy volunteers in sodium heparin tubes and divided in two aliquots of 3 mL. The former aliquot was mechanically hemolyzed by aspiration with 0.5 mL insulin syringe equipped with 30 gauge needle. One milliliter of all aliquots was tested for hemoglobin, pH, oxygen partial pressure (pO2), partial pressure of carbon dioxide (pCO2), bicarbonate (HCO3-), oxygen tension at 50% hemoglobin saturation (p50), oxygen saturation (sO2), actual base excess (ABE), carboxyhemoglobin (COHb), methemoglobin (metHb), ionized calcium (Ca2+) and potassium, on ABL800 flex. The remaining 2 mL of blood were centrifuged, plasma separated and tested for hemolysis index. Results: The concentration of cell-free hemoglobin increased from <0.5 g/L to 8.9±1.5 g/L in hemolyzed aliquots. In hemolyzed blood, significant decreases were found for pH (-0.2%), pO2 (-4.9%), sO2 (-4.9%), COHb (-11%) and Ca2+ (-7.0%), whereas significant increases were observed for pCO2 (+4.1%), HCO3- (+1.4%) and potassium (+152%). Clinically meaningful bias was found for pO2, pCO2, Ca2+ and potassium. Conclusions: Spurious hemolysis is likely to introduce meaningful biases in blood gas analysis, hence manufacturers of blood gas analyzers should develop instrumentation capable of identifying interfering substances in whole blood. The presence of spurious hemolysis should also be suspected whenever test results do not reflect the clinics
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