1,721,068 research outputs found
Luigi Pace and Alessandra Salvan's contribution to the Discussion of 'Safe testing' by Grünwald, de Heide, and Koolen
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Parameter estimation in a biological two compartment model. II: A computer experimental study of the influence of the initial estimate in the parameter space, of some sampling protocols and of weighting factors.
No full textA previous study [1] on conditions affecting parameterestimation in atwocompartmentmodel is extended. In this paper the following factors and their interaction have been examined: the initial guess in the parameterspace, sampling procedures at constant time intervals, data truncations and weightingfactors in the criterion function
Parameter estimation in a biological two compartment model. A computer experimental study of the influence of the initial estimate in the parameter space and of the model representation.
No full textParameterestimation in biologicalcompartmentmodels by optimization procedures is influenced by several conditions: the kind of mathematical representation of the model, the experimental conditions and the conditions related to the estimation process. In this paper the reliability of parameterestimation in atwocompartmentmodel is investigated through computer simulation techniques. In particular, the combined effect is studied of the initial guess in the parameterspace and of the mathematical representation of the model. The results show that there are some more favorable situations for the estimation. This analysis can help in proper planning of the experimental and computing conditions in which parameterestimation should be performed
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