1,720,974 research outputs found
Non-alcoholic fatty liver disease: further expression of the metabolic syndrome.
No full textNon-alcoholic fatty liver disease has been associated with metabolic disorders, including central obesity, dyslipidemia, hypertension and hyperglycemia. Metabolic syndrome, obesity, and insulin resistance are major risk factors in the pathogenesis of non-alcoholic fatty liver disease. Non-alcoholic fatty liver disease refers to a wide spectrum of liver damage, ranging from simple steatosis to non-alcoholic steatohepatitis, advanced fibrosis and cirrhosis
Contrast-enhanced ultrasound evaluation of peripheral microcirculation in diabetic patients: effects of cigarette smoking.
No full textGestione dietetico-nutrizionale dei pazienti con diabete tipo 2 e obesità sottoposti a interventi di chirurgia bariatrica
No full textClinical efficacy of bariatric surgery versus liraglutide in patients with type 2 diabetes and severe obesity: a 12-month retrospective evaluation
No full textTo evaluate the clinical efficacy of bariatric surgery vs medical therapy with liraglutide on weight loss, glycemic control and cardiovascular risk profile in patients with type 2 diabetes and severe obesity
Weight loss in obese type 2 diabetic patients on an intensive therapeutic programme: Importance of an initial short hospitalization period.
No full text
Effects of Sleeve Gastrectomy and Gastric Bypass on Postprandial Lipid Profile in Obese Type 2 Diabetic Patients: a 2-Year Follow-up
No full textBariatric surgery (BS) is known to favorably impact fasting lipid profile. Fasting and postprandial lipids were evaluated before and 2 years after BS in obese type 2 diabetic (T2DM) patients. Methods A prospective study was conducted in 19 obese T2DM patients: ten undergoing sleeve gastrectomy (SG) and nine undergoing Roux-en-Y gastric bypass (RYGB). Before and 2 years after BS, clinical parameters and the response of lipid and incretin hormones to a mixed meal (MM) were assessed. Results The two groups had similar characteristics at baseline.After BS, weight loss was similar in the two groups (p≤0.01). Fasting glucose, insulin, and triglycerides decreased while HDL cholesterol increased in a similar way (p<0.05); in contrast, fasting LDL cholesterol decreased only after RYGB (p<0.05). Post-meal glucose concentrations decreased while early insulin response significantly improved after both procedures (p<0.001 for both). Postprandial triglycerides decreased after both procedures (p<0.05) while postprandial LDL cholesterol decreased only after RYGB (p<0.05). Meal-GLP-1 increased postoperatively in both groups although to a greater extent after RYGB (p<0.001 vs. SG). GIP decreased after both procedures, especially after RYGB (p=0.003). At multivariate analysis, GLP-1 peak was the best predictor of LDL reduction (β=−0.552, p=0.039) while the improvement of HOMA-IR (β=0.574, p=0.014) and weight loss (β=0.418, p=0.036) predicted triglycerides reduction. Conclusions Both surgical procedures markedly reduce fasting and postprandial triglycerides and increase HDL cholesterol levels. LDL cholesterol decreases only after RYGB through a mechanism likely mediated by the restoration of GLP-1
Effects of bezafibrate on insulin secretion and peripheral insulin sensitivity in hyperlipidemic patients with and without diabetes.
No full text- …
