204,755 research outputs found
Sala Galán teatro, danza, vídeo, teatro, novas músicas, instalacións, café concerto, videodanza
No full text1 lám. (cartel) ; 65 x 35 c
IL MONITORAGGIO DEGLI AEROSOL ASPETTI TEORICI E PRATICI PER LA VALUTAZIONE DELL’ESPOSIZIONE
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Inhibition of erythro-myeloid differentiation by constitutive expression of a DNA binding-deficient c-myb mutant: implication for c-myb function.
No full textThe c-myb proto-oncogene encodes a nuclear protein involved in the regulation of cell proliferation, differentiation, and development. Myb protein contains a DNA binding and a transactivating domain thought to mediate its biologic properties. The DNA binding domain consists of three repeats (R1, R2, and R3), each containing a highly conserved motif of tryptophan residues. A c-myb mutant (DR1-myb) lacking the last 46 amino acids of R1 and 23 amino terminal residues of R2, a region homologous to the ADA-2 yeast transcriptional adaptor, lost DNA binding ability, but remained able to transactivate the human heat-shock promoter. Transfection of murine 32D and murine erythroleukemia (MEL) cell lines with DR1-myb caused inhibition of cellular differentiation induced by granulocyte colony-stimulating factor (G-CSF) and dimethyl sulfoxide (DMSO), respectively. A second c-myb mutant (D-ADA2-myb) lacking the first 23 amino acids of R2, also lost DNA binding and transactivation activity, but did not inhibit DMSO-induced differentiation of MEL transfected cells. These findings suggest that deletion of R1 activates a DNA binding-independent mechanism of c-myb function, which may involve interaction of Myb with cellular factors
Isernia La Pineta
No full textSi descrive l'insediamento paleolitico di Isernia La Pineta rilevando la sua importanza nel contesto nazionale e internazional
Lympha technique for primary and early secondary prevention of lymphedema following cancer treatment
No full textLYMPHA proved to be an effective preventive procedure that contributes in giving our oncological patients a good quality of life. In this presentation, the author will report indications, technical aspects and benefits of LYMPHA technique
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