1,720,990 research outputs found
Development of a transdermal patch for delivery of propafenone: preliminary studies in vitro
No full textPropafenone, a well-known antiarrhythmic drug, has a low oral bioavailability due to extensive hepatic first-pass metabolism The present study was aimed at verifying, on a preliminary basis, feasibility of transdermal delivery of the drug. Propafenone is apparently unable to penetrate the skin in the absence of appropriate enhancers. Different prospective enhancers (terpenes, azone) for the drug hydrochloride and base were evaluated in vitro using hairless mouse skin. Propafenone hydrochloride and atone, the most favourable drug species and enhancer combination, were then incorporated into semisolid vehicles, designed to act as reservoirs in transdermal patches. The patches, with and without a microporous membrane and adhesive layer were then tested for transdermal release using the same in vitro model. Skin, not membrane permeation, was found to be the rate-limiting step in delivery from the final patches. These, after 5 to 6 h lag times, delivered propafenone hydrochloride at a constant rate (5.4 to 27.5 mu g/cm(2)/h) for over 48 h. Since the literature data on intravenous infusion of propafenone appear to indicate the need for higher rates, further research on more effective promoters and transdermal patches is in progres
Substantive sunscreens as anti-ageing agents: structure-activity relationships
No full textThe aim of the study was verify he skin penetration of the highly skin-substantive quaternary ammonium derivatives, in comparison with their parent, non-quaternarized compounds
[Ophthalmic mucoadhesive vehicles: preliminary study of ocular pharmacokinetics "in vivo"]. FT Veicoli oftalmici mucoadesivi: studio preliminare della farmacocinetica oculare "in vivo".
No full textFiltri solari sostantivi: preparazione e valutazione delle caratteristiche di permeazione cutanea di alcuni derivati benzofenonici contenenti gruppi ammonici quaternari.
No full text[Formulations containing complexes of ophthalmic drugs with tannic acid: "in vitro" and "in vivo" evaluation]. FT Formulazioni contenenti complessi di farmaci oftalmici con acido tannico: preparazione e valutazione "in vitro" e "in vivo".
No full textPreparati oftalmici a base di polisaccaridi mucoadesivi con capacità riepitelizzante della cornea
No full textSoluzioni oftalmiche contenenti arabinogalactans con una attività protettiva sull'epitelio corneale, particolarmente adatto per l'uso come lacrime artificiali stimolare la ripresa delle lesioni corneali e anche particolarmente utile per gli utenti di lenti a contatto, contenenti da 1% al 10% in peso di Arabinogalattano in una soluzione acquosa ed eventuali altri eccipienti, tra cui tonicità-regolatori dell'acidità, gli correttori di pH, tamponi e conservanti, ad eccezione di benzalconio cloruro.
Le composizioni secondo l'invenzione ha una viscosità pressoché trascurabile, ma sono sufficientemente mucoadesive per garantire un tempo di permanenza nel campo di applicazione.
Oltre ad essere ben tollerato, i suddetti composizioni hanno notevoli capacità di riepitelizzazion
Ophthalmic composition containing mucoadhesive polysaccharides stimulating corneal epithelium recovery
No full text
Ophthalmic composition containing mucoadhesive polysaccharides able to promote corneal re-epithelization
No full textOphthalmic solutions containing arabinogalactans With a
protective activity on the corneal epithelium, particularly
suitable for use as arti?cial tears stimulating the recovery of
corneal lesions and also particularly useful for contact lens
users, containing from 1% to 10% by Weight of arabinoga
lactan in an aqueous solution and possible other excipients,
among Which tonicity-adjusting agents, pH correctors, buff
ers and preservatives, except for benZalkonium chloride.
The compositions according to the invention have a virtually
negligible viscosity, but are suf?ciently mucoadhesive to
assure a considerable permanence time in the area of appli
cation. Besides being Well-tolerated, the aforesaid composi
tions have considerable re-epitheliZation capacity
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