1,720,986 research outputs found
URBAN FLOWS SIMULATOR BASED ON COMPLEX SYSTEM OF QUEUES: PROCEDURES FOR SIMULATOR GENERATION
Full text linkIn a previous work [Pasini L and Feliziani S 2013 TASK Quart. 17 (3) 155], we have defined an object library that allows the building of architectural models of urban traffic systems. In this work we illustrate the procedures that enable us to produce a system simulator starting from the architectural model of an urban vehicular traffic system
Cloud: Presente e futuro
No full textCloud is an emerging technology that allows making the
increasing demand of advanced technology at a lower
cost, in an easier and more effective manner. This article
will contain some information regarding this new
technology. The emphasis will be both on state of the art
and objectives of future research about cloud. In
particular, Section 1 provides introductory information
about cloud. Section 2 provides a set of common
definitions and deepens cloud’s features from different
perspectives. Section 3 analyzes the usage scenarios for
cloud and in particular, what features are considered
most important. Section 4 compares the strengths and
characteristics of cloud against its current usage. Section
5 explores the major research topics and assesses their
complexity and relevance. Section 6 concludes the report
with a series of general considerations
Cloud Readiness Assessment of Legacy Application
Full text linkApplications and services hosted in the cloud are increasing continuously. Cloud technology offers important perspectives (performance, high availability, elasticity) and it enables new business models. Unfortunately, this new paradigm faces unprecedent requirements not addressed in legacy application (multi-tenancy, scalability, etc.). This leads to complex re-engineering phases in order to to migrate existing software into a cloud environment. Before starting a migration, it is important to analyze the cloud compliance of the application, what to expect after the migration and the effort required to fulfill these expectations. This paper assesses a way to extract an index that describes the feasibility of the re-engineering. We test the metric with a real application that needs to be migrated to a private cloud
Peptides derived from the proteolysis of serum proteins and immunoglobulins induce IL-1beta production independently of inflammasome activation
No full textAspartyl proteinases of Candida albicans induce caspase-11: implication in promoting inflammatory response.
No full text
Inflammatory response during human vaginal infection with Candida albicans
No full textIntroduction. The microbiological, pathological and clinical factors determining vaginal candidiasis and recurrent vaginal candidiasis have long been studied, particularly using rodent models. The validity of which for understanding the pathogenesis of disease in women has been questioned. The most prevalent agent is critically determined by activation of microbial and host factors leading to persistent vaginal inflammation coupled to the inability of the inflammatory cells to resolve the fungal infection. Here we studied the activation of inflammasome complex neutrophil-recruiting and activating cytokines in the vaginal secretion of women with clinically established vaginal candidiasis.
Materials and methods. In human vaginal samples positive for C. albicans with vaginal candidiasis (n=20) and carriage (n=15), infiltration of neutrophils, inflammatory mediators such as IL-8 and IL-1β, activation of inflammasome complex and expression of aspartyl proteases (SAPs) were examined.
Results. In vaginal swabs of patients with vaginal candidiasis we found: i) consistent recruitment of neutrophils; ii) appreciable level of IL-8 and IL-1β; iii) activation of inflammasome complex; iv) consistent expression of SAP2, SAP5 and SAP6.
Conclusions. These results show that immunopathogenesis of vaginal candidiasis is mediated by local recruitment of neutrophils, inflammatory cytokines secretion and inflammasome activation that mirror the upregulation of SAP2, SAP5 and SAP6 gene expression
A Role for Yeast/Pseudohyphal Cells of Candida albicans in the Correlated Expression of NLRP3 Inflammasome Inducers in Women With Acute Vulvovaginal Candidiasis
No full textInitial In Vivo Evaluation of a Novel Amikacin-Deoxycholate Hydrophobic Salt Delivers New Insights on Amikacin Partition in Blood and Tissues
Full text linkIn this study, an initial in vivo evaluation of a new amikacin-deoxycholate hydrophobic salt aimed at potentiating amikacin action against hard-to-treat lung infections was undertaken by quantifying, for the first time, amikacin in whole blood. Pharmacokinetic evaluation after intranasal administration in a murine model showed higher drug retention in the lungs compared to blood, with no significant differences between the salt and the free drug. Upon repeated administrations, the two treatments resulted in nonsignificant tissue damage and mild higher inflammation for the hydrophobic salt. Whole-blood analysis highlighted an unreported high partition of amikacin in blood components up to 48 h, while significant lung levels were measured up to 72 h. Such a new observation was considered responsible for the nearly overlapping pharmacokinetic profiles of the two treatments. To overcome such an issue, a dry powder in an inhalable form may be best suited. Moreover, if confirmed in humans, and considering the current once-a-day regimen for amikacin aerosols, important yet-to-be-explored clinical implications may be postulated for such amikacin persistence in the organism
A role for secretory aspartyl proteinases of Candida albicans in mouse vaginal inflammation and vaginal candidiasis
No full text- …
