1,721,038 research outputs found
Tidal deformation of neutron stars from microscopic models of nuclear dynamics
No full textThe observation of the gravitational wave signal GW170817, consistent with emission from the inspiral of a binary neutron-star system, provided information on the tidal deformation of the participating stars. The available data may be exploited to constrain the equation of state of dense nuclear matter as well as to shed light on the underlying models describing nuclear dynamics at the microscopic level. In this paper, we compare the experimental results to the predictions of different theoretical models, based on nonrelativistic nuclear many-body theory, the relativistic field-theoretical formalism, and a more phenomenological approach constrained by observed nuclear properties. Although the precision of the available data does not allow to resolve the degeneracy of the models, our analysis shows a distinct sensitivity to the star compactness predicted by the different equations of state, which turns out to be significantly affected by relativistic boost corrections to the nucleon-nucleon potential
Comparative structural analysis of low molecular mass fragments of Rapana venosa hemocyanin obtained using two different procedures
No full textDifferent fragments of the hemocyanin (He) isolated from the gastropod Rapana venosa containing a single functional unit (50 kDa), two functional units (100 kDa) and three functional units (150 kDa) were obtained in a dissociating buffer in the presence of Zn2+ and purified to homogeneity. Their conformations in solution were studied by means of small angle X-ray scattering (SAXS) and compared with those of the corresponding fragments previously obtained by limited proteolysis [Arch. Biochem. Biophys., 2000, 373, 154]. The overall shape of each fragment was determined using an ab initio approach. The crystal structures of the functional unit e from the same He and from another molluscan He (Octopus dofleini) were used to model 100 and 150 kDa fragments using rigid body movements to fit the corresponding SANS patterns. Interesting differences were observed between the functional unit organization in the low-molecular mass fragments according to the two preparation methods, suggesting different localizations within the 11S functional subunit
Effect of Enveloppe Linguale Nocturne on Atypical Swallowing: surface Electromyography and computerized Postural test evaluation.
No full textGPR55 and its Interaction with Membrane Lipids: Comparison with Other Endocannabinoid-Binding Receptors
No full textA number of integral membrane G protein-coupled receptors (GPCRs) share common structural features (including palmy-toilated aminoacid residues and consensus sequences specific for interaction with cholesterol) that allow them to interact with lipid rafts, membrane cholesterol-rich microdomains able to regulate GPCR signalling and functions. Among GPCRs, type-1 and type-2 cannabinoid receptors, the molecular targets of endocannabinoids (eCBs), control many physiological and pathological processes through the activation of several signal transduction pathways. Recently, the orphan GPR55 receptor has been proved to be activated by many eCBs, thus leading to the hypothesis that it might be the "type-3" cannabinoid receptor. While the biological activity of eCBs and the influence of membrane lipids on their functions are rather well established, information regarding GPR55 is still scarce and often controversial. Based on this background, here we shall review current data about GPR55 pharmacology and signalling, highlighting its involvement in several pathophysiological conditions. We shall also outline the structural features that allow GPR55 to interact with cholesterol and to associate with lipid rafts; how the latter lipid microdomains impact the biological activity of GPR55 is also addressed, as well as their potential for the discovery of new therapeutics useful for the treatment of those human diseases that might be associated with alterations of GPR55 activity
Effetti di un trattamento ortopedico ortodontico in soggetto affetto da cheilognatopalatoschisi.
No full text- …
