144 research outputs found
Crystal structure of 3,3-dimethyl-1,5-dioxa-9-thiaspiro[5.5]-undecane-9-oxide,9-N-[(4-methyl-benzenesulfonyl)imine], C17H25NO5S2
No full text
Antiviral flavanoid from Pterocaulon sphacelatum, an Australian Aboriginal medicine
No full textThe antipicornaviral activity of an ethanolic extract of the green aerial parts of the Australian plant Pterocaulon sphacelatum (Labill.) Benth. & Hook. f. ex F. Muell. has been investigated. This plant has been a favoured traditional medicine, used for the treatment of colds by the Australian Aboriginal people. Antiviral activity-guided fractionation of the extract of P. sphacelatum using an inhibition of poliovirus-induced cytopathic effect assay, has yielded the antiviral flavonoid chrysosplenol C (3,7,3'-trimethoxy-5,6,4'-trihydroxyflavone). This compound is a 4'-hydroxy-3-methoxyflavone, one of a group of compounds known to be potent and specific inhibitors of picornaviral replication. These compounds inhibit the replication of rhinoviruses, the most frequent causative agent of the common cold. The coumarin 6,7,8-trimethoxycoumarin was also isolated from the ethanolic extract.S.J Semple, S.F Nobbs, S.M Pyke, G.D Reynolds, R.L.P Flowe
Crystal structure of 1-(4-nitrophenyl)-3-(phenylsulfonyl)-2,5-dihydro-1H-pyrrole, C(16)H(14)N(2)O(4)S
No full textC16H14N2O4S, monoclinic, P121/n1 (No. 14), a = 6.291(6) Å, b = 23.73(1) Å, c = 10.175(7) Å, β = 92.68(8)°, V= 1517.3 Å3, Z = 4, Rgt(F) = 0.062, wRref(F2) = 0.168, T= 293 K. © 2014 Oldenbourg Wissenschaftsverlag GmbH, Rosenheimer Str. 145, 81671 München. All rights reserved.W. A. Pearce, S. M. Pyke and E. R. T. Tiekin
Crystal structure of (E)-1,3-di(2,4,6-trimethoxyphenyl)-2-propen-1-one,C(21)H(24)O(7)
No full textC21H24O7, triclinic, P1̄ (No. 2), a = 9.122(4)Å, b = 15.188(4)Å, c = 7.342(4) Å, α = 99.74(3)°, β = 96.14(4)°, γ = 94.11(3)°, V = 992.6Å3, Z = 2, Rgt(F) = 0.058, wRref(F2) = 0.169, T = 173 K. © by Oldenbourg Wissenschaftsverlag.P. J. Kerr, S. M. Pyke, A. D. Ward and E. R. T. Tiekin
Crystal structure of N1-(hexahydro-1lambda(6)-thiopyran-1-yliden)-1-benzenesulfonamide, C(12)H(17)NO(2)S(2)
No full textC12H17NO2S2, monoclinic, P1211 (No. 4), a = 8.953(9) Å, b = 16.135(8) Å, c = 9.049(4) Å, β = 104.90(6)°, V = 1263.2 Å3, Z = 4, Rgt(F) = 0.041, wRref(F) = 0.045, T = 113 K. © by Oldenbourg Wissenschaftsverlag.S. P. Creaser, S. M. Pyke and E. R. T. Tiekin
Crystal structure of (Z)-3-(1,3-benzodioxol-5-yl)-3-chloro-1-[2,4-di(benzyl-oxy)-6-hydroxyphenyl]-2-propen-1-one, C(30)H(23)ClO(6)
No full textC30H23ClO6, orthorhombic, P212121 (No. 19), a = 17.17(1) Å, b = 19.346(4) Å, c = 14.525(4) Å, V = 4824.8 Å3, Z = 8, Rgt(F) = 0.051, wRref(F2) = 0.157, T= 173 K. © by Oldenbourg Wissenschaftsverlag.P. J. Kerr, S. M. Pyke, A. D. Ward and E. R. T. Tiekin
Crystal structure of 1-[2,4-di(benzyloxy)-6-hydroxyphenyl]-3-phenyl-2-propyn-1-one, C(29)H(22)O(4)
No full textC29H22O4, triclinic, Pī (No. 2), a= 10.795(3) Å, b= 12.877(5) Å, c = 7.877(2) Å, α = 97.20(3)°, β = 96.21(2)°, γ = 84.00(2)°, V= 1075.4 Å3, Z = 2, Rgt(F) = 0.049, wRref(F2) = 0.179, T= 173 K. © 2014 Oldenbourg Wissenschaftsverlag GmbH, Rosenheimer Str. 145, 81671 München. All rights reserved.P. J. Kerr, S. M. Pyke, A. D. Ward and E. R. T. Tiekin
Selective biocatalytic hydroxylation of unactivated methylene C-H bonds in cyclic alkyl substrates
No full textThe cytochrome P450 monooxygenase CYP101B1 from Novosphingobium aromaticivorans selectively hydroxylated methylene C-H bonds in cycloalkyl rings. Cycloketones and cycloalkyl esters containing C6, C8, C10 and C12 rings were oxidised with high selectively on the opposite side of the ring to the carbonyl substituent. Cyclodecanone was oxidised to oxabicycloundecanol derivatives in equilibrium with the hydroxycyclodecanones.Md Raihan Sarkar, Samrat Dasgupta, Simon M. Pyke and Stephen G. Bel
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