194 research outputs found
Stato attuale delle conoscenze sugli Histeridae ipogei
No full textThe author makes some considerations on troglobitic and endogeous world Histeridae. All these species present extreme reduction of eyes or are completely blind; all are wingless and only one is brachipterous. The Histeridae described here belong to the following genera: Speleacritus Jeannel and Spelaeabraeus Moro (Abraeinae), Sardulus Patrizi, Bacanius Le Conte, Troglobacanius Vomero and Geoculus Wenzel. (Dendrophilinae, Bacanius group). Finally some considerations on troglophylic and guanobitic Histeridae are made, reporting the recent discovery of a new genus and of some new species belonging to guanobitic biocoenosis of Mexican tropical caves
Synthesis of 1,2,4,-Triazolo[4',3':1,6]pyridazino[4,5-b]quinoline Derivatives
No full textThis paper reports the synthesis of 10‐phenyl‐2H‐pyridazino[4,5‐b]quinoline‐1‐thione 10 and its further transformation into the hitherto unknown 12‐phenyl‐1,2,4‐triazolo[4′,3′:1,6]pyridazino[4,5‐b]quinoline 4. 3‐Carbethoxy‐2‐dichloromethyl‐4‐phenylquinoline 8 was reacted with hydrazine to give 9 which in turn was transformed by the Lawesson Reagent into the corresponding thione 10. On treating 10 with anhydrous hydrazine, 11 was obtained and subsequently cyclized in the presence of formic or acetic acids to afford the tetracyclic derivatives 4a and 4b, respectively, in satisfactory yields. When 3‐carbethoxy‐2‐chloromethyl‐4‐phenylquinoline 5 was reacted with hydrazine, compound 7 was the sole isolated product. Copyright © 1990 Journal of Heterocyclic Chemistr
Synthesis of Functionalized Derivatives of Quinazolines and 1,4-Benzodiazepines
No full textThe 2-substituted 1,4-benzodiazepines (4 and 6) were synthesized. The reaction of 2-aminobenzophenone oximes with ethyl 4-chloroacetoacetate gave the 1,4-benzodiazepines (4) and the 1,2-dihydroquinazolines (5); the latter were treated with a base to result ring expansion giving the 1,4-benzodiazepines (6)
Characterization of quinoline derivatives. I. 6,7-Dihydro-8-(4-methyl-1-piperazinyl)[1]-benzoxepino[4,5-c]quinoline 0.13-hydrate
No full textThe title compound, C22H23N3O.0.13H(2)O, is a novel potent and selective serotonin 5-HT3 receptor antagonist. Three independent molecules constitute the asymmetric unit. While two of these molecules show only small differences in their metric and conformational parameters, the third differs from the other two, mainly as a result of the conformation of the oxepine ring. The conformations of the seven-membered ring determine quite different orientations of the oxepine-fused benzene ring, whose role is important in the exploitation of biological activity
Synthesis of 6,7-Dihydro-8-(4-methyl-1-piperazinyl)-[1]benzoxepino[4,5-c]quinoline as Potential 5-HT3 Receptor Ligand
No full textTwo synthetic routes to the achievement of the title compound are described. The [1]benzoxepino[4,5-c]quinoline nucleus was prepared by nucleophilic aromatic fluoride displacement-cyclization and functionalized with N-methylpiperazine moiety. Alternatively the oxepino ring closure is shifted as the final step. An oxepine ring cleavage occurred in compounds (9) and (3); a mechanistical interpretation is proposed
Synthesis of 6-(4-Methyl-1-piperazinyl)-7H-indeno[2,1-c]quinoline Derivatives as Potential 5-HT Receptor Ligands
No full textTwo synthetic pathways for the achievement of the title compounds are reported. The key intermediate, namely 3-carboxy-4-phenyl-2(1H)-quinolinone 9, was directly cyclized into the corresponding 6-chloro-7H-indeno[2,1-c]quinolin-7-one 10 or alternatively it was esterified, reduced to the alcohol, chlorinated and cyclized into the 6-chloro-7H-indeno[2,1-c]quinoline 8. Further reaction of the chloroindenoquinoline derivatives with N-methylpiperazine afforded the piperazinyl derivatives 4a-c
Interaction between nanoparticles composed by poly-VC851, a new lipophilic polymer, and CR3124, a potent 5-HT3 receptor antagonist
No full textPermanences and morphologies of historical landscapes. The hill of the Vomero in Naples
No full textThe historical iconography of Naples until the end of the nineteenth century has reproduced the image of a seaside town surrounded by green hills in which they were built next to houses, villas and small rural centers, great architectures such as the Castel Sant'Elmo with the Certosa, the Palace of Capodimonte, the hermitage of Camaldoli. Subsequently, the landscape of the town has changed: it has intensified the building fabric until to endanger a cultural heritage of world renown.
The hill of the Vomero was the one that more has lived important changes that have led to a strong alteration of its original configuration.
The paper aims to identify, through a collation of historical views and topographic maps with cartography latest, several surviving elements of historical landscapes that no longer exist in an area that has over time changed its activity from agricultural to edificatoria.
Particular attention will be paid also to the identification of the ancient footpaths that connected the city to the hill of the Vomero, still present in the urban fabric as the ascent of Petraio and of S. Francis and the Pedamentina. These small streets, no longer having the original function being changed over time the road system of the town, tend to degrade more and more.
The objective of this paper is to expand and sustain the processes of knowledge of the cultural identity of a place to help to conserve memory and to safeguard the cultural heritage in danger of disappearing forever
New insight into the central benzodiazepine receptor-ligand interactions: design, synthesis, biological evaluation, and molecular modeling of 3-substituted 6-phenyl-4H-imidazo[1,5-a][1,4]benzodiazepines and related compounds
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