3,981 research outputs found
Oral History Interview, Jeremi Suri (1033)
No full textIn his six February-May 2009 interviews with Bob Lange, Jeremi Suri discusses his education and his work at the University of Wisconsin-Madison. To learn more about this oral history, download & review the index first (or transcript if available). It will help determine which audio file(s) to download & listen to.In his six February-May 2009 interviews with Bob Lange, Jeremi Suri discusses his education and his work at the University of Wisconsin-Madison. Suri related details of his upbringing in New York City, reasons for his interest in international diplomacy, and major influences on his thinking. He then goes on to explain how he arrived at Madison, his major projects, and his teaching and service at the university. This interview was conducted for inclusion into the UW-Madison Archives and Records Management Oral History Program
Principles of Computed Tomography
No full textAtherosclerosis represents the leading cause of mortality and morbidity in the world. Two of the most common, severe, diseases that may occur, acute myocardial infarction and stroke, have their pathogenesis in the atherosclerosis that may affect the coronary arteries as well as the carotid/intra-cranial vessels. Therefore, in the past there was an extensive research in identifying pre-clinical atherosclerotic diseases in order to plan the correct therapeutical approach before the pathological events occur. In the last 20 years imaging techniques and in particular Computed Tomography and Magnetic Resonance had a tremendous improvement in their potential. In the field of the Computed Tomography the introduction of the multi-detector-row technology and more recently the use of dual energy and multi-spectral imaging provides an exquisite level of anatomic detail. The MR thanks to the use of strength magnetic field and extremely advanced sequences can image human vessels very quickly while offering an outstanding contrast resolution
The ovarian endometrioma: clinical setting and ultrasound findings
No full textOvarian endometrioma is defined as a pseudocyst arising from gorwth of ectopic endometrial tissue. The typical features of endometriomas are diffuse low-level internal echoes ("ground glass") in the absence of particular neoplastic features and with a clear demarcation from ovarian parenchyma. Several studies report very high values of specificity with values of sensitivity usually ranging from 87 to 77%
CT imaging of coronary arteries
No full textAtherosclerosis represents the leading cause of mortality and morbidity in the world. Two of the most common, severe, diseases that may occur, acute myocardial infarction and stroke, have their pathogenesis in the atherosclerosis that may affect the coronary arteries as well as the carotid/intra-cranial vessels. Therefore, in the past there was an extensive research in identifying pre-clinical atherosclerotic diseases in order to plan the correct therapeutical approach before the pathological events occur. In the last 20 years imaging techniques and in particular Computed Tomography and Magnetic Resonance had a tremendous improvement in their potential. In the field of the Computed Tomography the introduction of the multi-detector-row technology and more recently the use of dual energy and multi-spectral imaging provides an exquisite level of anatomic detail. The MR thanks to the use of strength magnetic field and extremely advanced sequences can image human vessels very quickly while offering an outstanding contrast resolution
Most Likely Voronoi Diagrams in Higher Dimensions
No full textThe Most Likely Voronoi Diagram is a generalization of the well known Voronoi Diagrams to a stochastic setting, where a stochastic point is a point associated with a given probability of existence, and the cell for such a point is the set of points which would classify the given point as its most likely nearest neighbor. We investigate the complexity of this subdivision of space in d dimensions. We show that in the general case, the complexity of such a subdivision is Omega(n^{2d}) where n is the number of points. This settles an open question raised in a recent (ISAAC 2014) paper of Suri and Verbeek, which first defined the Most Likely Voronoi Diagram. We also show that when the probabilities are assigned using a random permutation of a fixed set of values, in expectation the complexity is only ~O(n^{ceil{d/2}}) where the ~O(*) means that logarithmic factors are suppressed. In the worst case, this bound is tight up to polylog factors
Garh Stone Inscription of the time of Mahhipala, V. S. 979
No full textB. Datta and C. L. Suri, "Garh Stone Inscription of the time of Mahhipala, V. S. 979," Epigraphia Indica 39, part 4 (1972): 189-98. © 198
Whole genome sequencing analysis of alpaca suggests TRPV3 as a candidate gene for the suri phenotype
No full textBackground: Alpaca is a domestic South American camelid probably arising from the domestication of two wild camelids, the vicugna and the guanaco. Two phenotypes are described for alpaca, known as huacaya and suri. Huacaya fleece is characterized by compact, soft, and highly crimped fibers, while suri fleece is longer, straight, less crimped, and lustrous. The gene variants determining these phenotypes are still unknown, although previous studies suggested a dominant inheritance of the suri. Based on that, the aim of this study was the identification of the gene variants determining alpaca coat phenotypes through whole genome sequencing (WGS) analysis. Results: The sample used includes two test-cross alpaca families, suri × huacaya, which produced two offspring, one with the suri phenotype and one with the huacaya phenotype. The analyzed sample was expanded through the addition of WGS data from six vicugnas and six guanacos; this because we assumed the absence of the gene variants linked to the suri phenotype in these wild species. The analysis of gene variant segregation with the suri phenotype, coupled with the filtering of gene variants present in the wild species, disclosed the presence in all the suri samples of a premature termination codon (PTC) in TRPV3 (transient receptor potential cation channel subfamily V member 3), a gene known to be involved in hair growth and cycling, thermal sensation, cold tolerance and adaptation in several species. Mutations in TRPV3 were previously associated with the alteration of hair structure leading to an impaired formation of the hair canal and the hair shaft in mouse. This PTC in TRPV3, due to a G > T substitution (p.Glu475*), results in a loss of 290 amino acids from the canonical translated protein, plausibly leading to a physiological dysfunction. Conclusion: The present results suggest that the suri phenotype may arise from a TRPV3 gene variant which may explain some of the suri features such as its longer hair fibre with lower number of cuticular scales compared to huacaya
Suri/Huacaya phenotype inheritance in alpaca (Vicugna pacos)
No full textThe Suri/Huacaya phenotype inheritance in alpaca was tested on rwo indipendent Peruvian sources of records: the Registry of Mallkin farm (588 offspring by Suri sire x Suri dam from 62 paternal half sib families, and 2,126 offspring by Huacaya sire x Huacaya dam froom 177 paternal half sib families) and the results of the Quimsachata INIA ILPA Puno experimental trial (two reciprocal experimental test-crosses, involving a total of 17 unrelated males and 149 unrelated females). The data support a genetic model in which two linked loci must simultaneously be homozigous for recessive alleles in order to produce Huacaya phenotype. The estimated recombination rate between these loci was 0.099 (95%C.L. =0.029-0.204). The Birth of 3 Suri offspring from Huacaya x Huacaya mating is explained by a new mutation on some germinal lines of Huacaya animals. The direct mutation can be estimated at 0.001
Fleece variation in the alpaca (Vicugna pacos): a two-locus model for the Suri/Huacaya phenotypes
No full textBackground
Genetic improvement of fibre-producing animal species has often induced transition from double
coated to single coated fleece, accompanied by dramatic changes in skin follicles and hair
composition, likely implying variation at multiple loci. Huacaya, the more common fleece
phenotype in alpaca (Vicugna pacos), is characterized by a thick dense coat growing
perpendicularly from the body, whereas the alternative rare and more prized single-coated Suri
phenotype is distinguished by long silky fiber that grows parallel to the body and hangs in separate,
distinctive pencil locks. A single-locus genetic model has been proposed for the Suri-Huacaya
phenotype, where Huacaya is recessive.
Results
Two reciprocal experimental test-crosses (Suri x Huacaya) were carried out, involving a total of 17
unrelated males and 149 unrelated females. An additional dataset of 587 offspring of Suri x Suri
crosses was analyzed. Segregation ratios, population genotype frequencies, and/or recombination
fraction under different genetic models were estimated by maximum likelihood. The single locus
model for the Suri/Huacaya phenotype was rejected. In addition, we present two unexpected
observations: 1) a large proportion (about 3/4) of the Suri animals is segregating (with at least one
Huacaya offspring), even in rearing conditions where the Huacaya trait would have been almost
eliminated; 2) a model with two different values of the segregation ratio fit the data significantly
better than a model with a single parameter.
Conclusions
The data support a genetic model in which two linked loci must simultaneously be homozygous for
recessive alleles in order to produce the Huacaya phenotype. The estimated recombination rate
between these loci was 9.9%. Our genetic analysis may be useful for other species whose breeding
system produces mainly half-sib families
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