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Dual-Function Multilayers for the Photodelivery of Nitric Oxide and Singlet Oxygen ChemPhysChem, 17 (2009) 3077-3082.
No full textIn this contribution we report the design, preparation and
characterization of bichromophoric Langmuir–Schfer multilayer
films which enable the simultaneous generation of nitric
oxide (NO) and singlet oxygen 1O2 (1Dg). They are achieved by
exploiting effective interfacial electrostatic interactions between
the floating film of a cationic amphiphilic nitric oxide
(NO) photodonor and an anionic porphyrin dissolved in the
water subphase. The morphology and the spectroscopic features
of the floating films at the water–air interface are inspected
by Brewster angle microscopy and UV/Vis reflection spectroscopy, respectively. Multilayer films containing both the
chromogenic centres are obtained by horizontal lifting deposition
onto hydrophobized quartz substrates and are characterized
by steady-state UV/Vis absorption, fluorescence and laser
flash photolysis. The anionic porphyrin units are entangled
into the films network mainly in their monomeric forms and
no significant intra and inter-chromophoric interaction occur in
the excited state, preserving the photochemical independency
of the two photoactive units in the multilayers. The capability
of the bichromophoric films to delivery NO and singlet oxygen,
1O2 (1Dg), under light excitation is unambiguously demonstrated
by the direct and in real time monitoring of these transient
species using an ultrasensitive electrode and a time-resolved
infrared luminescence apparatus, respectively
Light-Activated Nanoparticles for the Combined Therapy of Cancer
No full textSelezionata come presentazione oral
Deposizione, caratterizzazione ed applicazioni in ambito tecnologico di film sottili di sistemi ciclici tetrapirrolici
No full textIl Progetto di ricerca si è sviluppato lungo le seguenti linee principali:
a) studio del trasporto elettronico fotoindotto in sistemi costituiti da film di Langmuir-Blodgett di derivati fullerenici e porfirinici;
b) studio di equilibri conformazionali in film di Langmuir e di Langmuir-Blodgett di derivato bis-porfirinici;
c) realizzazione di sensori piezoelettrici in fase liquida nei quali lo strato attivo è sato cresciuto con la tecnica di Langmuir-Blodgett;
d) Modifica del set-up di uno spettrofotometro ATR-FTIR, opportunamente potenziato per acquisire spettri in modalità
differenziale
Simultaneous generation of nitric oxide and singlet oxygen from multilayers films of an organic dyad
No full textPhotoinduced release of nitric oxide and singlet oxygen from Langmuir-Schaefer films of porphyrins and other molecules for photodynamic therapy
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