176 research outputs found
Assessment of personality disorders in adolescents – a clinical validity and utility study of the structured interview of personality organization (STIPO)
No full textAbstract Background The diagnosis of personality disorders (PD) in adolescence still poses a challenge. Early diagnosis and targeted intervention are called for, since patients with PD present with severe consequences in terms of psychosocial functioning and personal suffering including higher suicide risk. New guidelines advise semi-structured interviews for the dimensional assessment of personality functioning. Methods We included 136 patients aged 13 to 17.9 years with a categorical PD diagnosis and 35 healthy control (HC) adolescents to assess the applicability of the Structured Interview for Personality Organization (STIPO) for adolescents and evaluate its validity by correlating the six outcome domains (identity, object relations, defenses, aggression, moral values, reality testing) and the overall severity level to several validated instruments. Furthermore, we assessed personality traits, internalizing and externalizing behavior and depressive symptoms. Results All STIPO domains differed significantly between patients and HC (p < 0.001). Outcome measures correlated significantly with validated self-rating questionnaires. STIPO severity levels correlated significantly with psychopathology. Personality traits “dissocial behavior” and “emotional dysregulation” correlated positively with all STIPO domains and the overall level of personality organization (PO). Conclusions Results indicate that the STIPO is a reliable and valid instrument for the assessment of PD in adolescents. It comprises the core elements of personality functioning, as requested in Criterion A in the AMPD of the DSM-5 and ICD-11 and could be useful for treatment planning, evaluation of the course of treatment as well as for prognostic considerations
Correlation between the STIPO dimension ‘identity’ and the fMRI signal change.
No full text<p>(a.) Left retrosplenium (MNI: −6, −54, 18), and (b.) Right retrosplenium (MNI: 9, −51, 18). Subjects showing a high personality organization according to the STIPO overall rating are highlighted in blue. Spearman correlation. <i>r<sub>s</sub></i>: Spearman rho. * 0.05</p
Título: Alexandreis
No full textMarca tip. en portSign.: *\p4\s, a-v\p4\sTipo de I.: "lettre de civilité
Phytosociological nomenclature of the class names Helianthemetea guttati, Poetea bulbosae and Stipo giganteae-Agrostietea castellanae
No full textThe EuroVegChecklist (EVC) is currently considered to be the basis for the phytosociological classification of the European vegetation, and it is therefore important that it is continually updated, improved and refined. This article revises the nomenclature of three Mediterranean grassland-related classes and some of their contents down to the rank of association, namely Helianthemetea guttati, Poetea bulbosae and Stipo giganteae-Agrostietea castellanae, on the basis of the fourth edition of the International Code of Phytosociological Nomenclature (ICPN). The results show that the correct author citations for the first two classes are as follows: Tuberarietea guttatae Braun-Blanquet 1973, and Poetea bulbosae Rivas Goday et Rivas-Martínez ex Navarro Andrés et Valle Gutiérrez 1984. Instead, the name Stipo giganteae-Agrostietea castellanae is invalid and it is replaced by the new class name Agrostietea castellanae. In addition, we designate the neotype of the association Corynephoro articulati-Helianthemetum guttati (Corynephoro divaricati-Tuberarietum guttatae nom. corr. nov. et mut. nov.), the lectotype of the Poo bulbosae-Trifolietum subterranei, and mutate the names Helianthemetalia guttati and Helianthemion guttati to Tuberarietalia guttatae and Tuberarion guttatae, respectively, as well as two names of associations with a name-giving taxon belonging to the genus Tuberaria
Reliability of different test setups and influence of mortar mixture on the fabric-reinforced cementitious matrix-to-brick bond response
No full textThe results of four different bond tests, conducted on specimens made of bricks and fabricreinforced cementitious matrix (FRCM) composite strips, are presented in this article. The composites consisted of a basalt textile embedded in four types of inorganic matrices: a commercial product made of lime mortar and three different mortars properly prepared in the laboratory. Bond tests were carried out to highlight variations in the bond behavior of the four composites. The experimental campaign, for all the tested composites, confirmed that the debonding mechanism occurs at the textile-matrix interface with large differences, in terms of load carrying capacity, between the four typologies of FRCM composite. In particular, composites made up of a commercial matrix were demonstrated to be the best ones to fully exploit the tensile strength, whereas composites made up of cement-lime mortar showed the worst bond behavior. Furthermore, the results of the four bond tests conducted on the same type of composite were compared to evaluate the reliability of the different types of bond tests. Among the apparatus used to conduct the four bond tests, the single shear test was demonstrated to be the most effective for determining the actual bond performances of FRCM composites
SHOC2 subcellular shuttling requires the KEKE motif-rich region and N-terminal leucine-rich repeat domain and impacts on ERK signaling
No full textSHOC2isascaffold protein composed almost entirely by leucine-rich repeats (LRRs) and having an N-terminal region enriched in alternating lysine and glutamate/aspartate residues (KEKE motifs). SHOC2 acts as a positive modulator of the RASRAF-MEK-ERKsignalling cascade by favouring stable RAF1 interaction with RAS. We previously reported that the p.Ser2Gly substitution in SHOC2 underlies Mazzanti syndrome, a RASopathy clinically overlapping Noonan syndrome, promoting N-myristoylation and constitutive targeting of the mutant to the plasma membrane. We also documented transient nuclear translocation of wild-type SHOC2 upon EGF stimulation, suggesting a more complex function in signal transduction. Here, we characterized the domains controlling SHOC2 shuttling between the nucleus and cytoplasm, and those contributing to SHOC2S2G mistargeting to the plasma membrane, analysed the structural organization of SHOC2’s LRR motifs, and determined the impact of SHOC2 mislocalization on ERK signalling. We show that LRRs 1 to 13 constitute a structurally recognizable domain required for SHOC2 import into the nucleus and constitutive targeting of SHOC2S2G to the plasma membrane, whilethe KEKEmotif-rich region is necessary to achieve efficient SHOC2 export from the nucleus. We also documentthat SHOC2S2G localizes both in raft and non-raft domains, and that it translocates to the non-raft domains following stimulation. Finally, we demonstrate that SHOC2 trapping at different subcellular sites has a diverse impact on ERK signalling strength and dynamics, suggesting a dual counteracting modulatory role of SHOC2 in the control of ERK signalling exerted at different intracellular compartments
Validación al Castellano de la Structured Interview of Personality Organization (STIPO-R) como Instrumento Diagnóstico de los Trastornos de la Personalidad
No full text[spa] El objetivo principal de este estudio es adaptar al idioma castellano y obtener evidencias de validez y fiabilidad de la Structured Interview of Personality Organization Revised (STIPO-R) (Clarkin y cols., 2016) como instrumento diagnóstico de la organización de la personalidad y de los trastornos de la personalidad (TP). Se ha llevado a cabo un estudio transversal en una muestra de 206 sujetos distribuidos en dos grupos, un grupo clínico de 134 pacientes psiquiátricos ambulatorios con diagnóstico de trastorno de la personalidad y un grupo control de 72 sujetos sin diagnóstico de trastorno de la personalidad en los últimos diez años. Se han estudiado por primera vez las evidencias de validez y la confiabilidad (consistencia interna) de la versión en castellano de la STIPO-R revisada, ya que no se dispone hasta la fecha de datos publicados del proceso de validación del instrumento original en inglés. Las evidencias de validez estudiadas han sido: la basada en el contenido de la prueba (validez de contenido); la basada en la estructura interna de la prueba (validez estructural) y la basada en las relaciones con otras variables (validez concurrente): el Personality Inventory for the DSM-5 (PID-5, Krueger y cols., 2012; adaptación al castellano Gutierrez y cols., 2017); y la Structured Clinical Interview for DSM – IV Axis II Personality Disorders (SCID – II, First y cols. 1997; adaptación al castellano, Gómez-Beneyto, 1994). Asimismo, se ha estudiado la capacidad de la versión en castellano de la STIPO-R revisada para diferenciar adecuadamente personalidad normal y personalidad patológica (validez de criterio). Los resultados muestran que la versión en castellano de la entrevista STIPO-R revisada tiene evidencias de validez basadas en el contenido de la prueba; en la estructura interna de la prueba (se confirma que la versión en castellano de la STIPO-R tiene 6 dominios psicopatológicos, como proponen los autores de la versión original en inglés, Clarkin y cols. (2016), que son: 1. Identidad, 2. Relaciones de Objeto, 3. Defensas primitivas, 4. Defensas de nivel avanzado, 5. Agresión y 6. Valores morales); y relación concurrente con otras variables, como son la SCID-II (perspectiva categorial) y el PID-5 (perspectiva dimensional). Por tanto, se confirma que la versión en castellano de la entrevista STIPO-R revisada es un instrumento con evidencias de validez, confiable (con adecuada consistencia interna) y con potencia diagnóstica para evaluar personalidad normal y patológica en línea con el Modelo Alternativo de los Trastornos de la Personalidad (MATP) del Manual DSM-5 (APA, 2013). Sería interesante desarrollar otros futuros estudios con los que comparar los resultados obtenidos.[eng] The main objective of this study is to adapt to the Spanish language and to obtain evidence s of validity and reliability of the Structured Interview of Personality Organization Revised (STIPO R) (Clarkin et al., 2016) as a diagnostic instrument for personality organization and personality disorders (PD). A cross sectional study has been carried out in a sample of 206 subjects distributed in two groups, a clinical group of 134 outpatient psychiatric patients with a diagnosis of personality disorder and a control group of 72 subjects without a diagnosis of personality disorder in the last ten years. The evidence s of validity and reliability (internal consistency) of the Spanish version of the STIPO R ha ve been studied for the first time, since no published data from the validation process of the original instrument in English is available to date. The evidence s of validity studied ha ve been content, structure and con curr ent validity with : the Personality Inventory for the DSM 5 (PID 5, Krueger et al., 2012; adaptation to Spanish Gutierrez et al., 2017); and the Structured Clinical Interview for DSM I V Axis II Personality Disorders (SCID II, First et al. 1997; Spanish adaptation, Gómez Beneyto, 1994). Likewise, criterion validity has been studied. The results show that the Spanish version of the STIPO R interview has evidence s of validity based on the content of the test; the internal structure of the test (it is confirmed that the Spanish version of the STIPO R has 6 psychopathological domains, as proposed by the authors of the original version in English, Clarkin et al. (2016 ), which are: 1. Identity, 2. Object Relations, 3. Primitive Defenses, 4. Advanced Level Defenses, 5. Aggression and 6. Moral Values); and concurrent relationships with other v ariables, such as the SCID II (categorical perspective) and the PID 5 (dimensional perspective). It is confirmed that the Spanish version of the STIPO R has evidence of validity, is reliable (with adequate internal consistency) and has diagnostic power to assess normal and pathological personality in line with the Alternative Model of Personality Disorders (MATP) of the DSM 5 (APA, 2013). It would be interesting to develop other studies with which to compare the obtained results
Validación al Castellano de la Structured Interview of Personality Organization (STIPO-R) como Instrumento Diagnóstico de los Trastornos de la Personalidad
No full textPrograma de Doctorat en Psicologia Clínica i de la Salut[spa] El objetivo principal de este estudio es adaptar al idioma castellano y obtener evidencias de validez y fiabilidad de la Structured Interview of Personality Organization Revised (STIPO-R) (Clarkin y cols., 2016) como instrumento diagnóstico de la organización de la personalidad y de los trastornos de la personalidad (TP).
Se ha llevado a cabo un estudio transversal en una muestra de 206 sujetos distribuidos en dos grupos, un grupo clínico de 134 pacientes psiquiátricos ambulatorios con diagnóstico de trastorno de la personalidad y un grupo control de 72 sujetos sin diagnóstico de trastorno de la personalidad en los últimos diez años.
Se han estudiado por primera vez las evidencias de validez y la confiabilidad (consistencia interna) de la versión en castellano de la STIPO-R revisada, ya que no se dispone hasta la fecha de datos publicados del proceso de validación del instrumento original en inglés. Las evidencias de validez estudiadas han sido: la basada en el contenido de la prueba (validez de contenido); la basada en la estructura interna de la prueba (validez estructural) y la basada en las relaciones con otras variables (validez concurrente): el Personality Inventory for the DSM-5 (PID-5, Krueger y cols., 2012; adaptación al castellano Gutierrez y cols., 2017); y la Structured Clinical Interview for DSM – IV Axis II Personality Disorders (SCID – II, First y cols. 1997; adaptación al castellano, Gómez-Beneyto, 1994). Asimismo, se ha estudiado la capacidad de la versión en castellano de la STIPO-R revisada para diferenciar adecuadamente personalidad normal y personalidad patológica (validez de criterio).
Los resultados muestran que la versión en castellano de la entrevista STIPO-R revisada tiene evidencias de validez basadas en el contenido de la prueba; en la estructura interna de la prueba (se confirma que la versión en castellano de la STIPO-R tiene 6 dominios psicopatológicos, como proponen los autores de la versión original en inglés, Clarkin y cols. (2016), que son: 1. Identidad, 2. Relaciones de Objeto, 3. Defensas primitivas, 4. Defensas de nivel avanzado, 5. Agresión y 6. Valores morales); y relación concurrente con otras variables, como son la SCID-II (perspectiva categorial) y el PID-5 (perspectiva dimensional). Por tanto, se confirma que la versión en castellano de la entrevista STIPO-R revisada es un instrumento con evidencias de validez, confiable (con adecuada consistencia interna) y con potencia diagnóstica para evaluar personalidad normal y patológica en línea con el Modelo Alternativo de los Trastornos de la Personalidad (MATP) del Manual DSM-5 (APA, 2013). Sería interesante desarrollar otros futuros estudios con los que comparar los resultados obtenidos.[eng] The main objective of this study is to adapt to the Spanish language and
to obtain
evidence s of validity and reliability of the Structured Interview of Personality
Organization Revised (STIPO R) (Clarkin et al., 2016) as a diagnostic instrument
for personality organization and personality disorders (PD).
A cross
sectional study has been carried out in a sample of 206 subjects
distributed in two groups, a clinical group of 134 outpatient psychiatric patients
with a diagnosis of personality disorder and a control group of 72 subjects without
a diagnosis of personality disorder in the last ten years.
The evidence
s of validity and reliability (internal consistency) of the Spanish
version of the STIPO R ha ve been studied for the first time, since no published
data from the validation process of the original instrument in English is available
to date. The evidence s of validity studied ha ve been content, structure and
con curr ent validity with : the Personality Inventory for the DSM 5 (PID 5, Krueger
et al., 2012; adaptation to Spanish Gutierrez et al., 2017); and the Structured
Clinical Interview for DSM I V Axis II Personality Disorders (SCID II, First et al.
1997; Spanish adaptation, Gómez Beneyto, 1994). Likewise, criterion validity has
been studied.
The results show that the Spanish version of the STIPO
R interview has
evidence s of validity based on the content of the test; the internal structure of the
test (it is confirmed that the Spanish version of the STIPO R has 6
psychopathological domains, as proposed by the authors of the original version
in English, Clarkin et al. (2016 ), which are: 1. Identity, 2. Object Relations, 3.
Primitive Defenses, 4. Advanced Level Defenses, 5. Aggression and 6. Moral
Values); and concurrent relationships with other v ariables, such as the SCID II
(categorical perspective) and the PID 5 (dimensional perspective). It is confirmed
that the Spanish version of the STIPO R has evidence of validity, is reliable (with
adequate internal consistency) and has diagnostic power to assess normal and
pathological personality in line with the Alternative Model of Personality Disorders
(MATP) of the DSM 5 (APA, 2013). It would be interesting to develop other
studies with which to compare the obtained results
Influence of Different Mortar Matrices on the Effectiveness of FRCM Composites for Confining Masonry Columns
No full textIn the past, steel hoops were applied over the height of columns to increase their load-bearing capacity. Currently, innovative strengthening techniques, namely fiber-reinforced composites, are successfully replacing traditional systems. Although fiber-reinforced polymers were demonstrated to be effective in the confinement of columns, the use of fabric-reinforced cementitious matrix (FRCM) systems is preferred in the case of masonry columns belonging to architectural heritage buildings because of the compatibility with the masonry substrate as well as the reversibility of the intervention. In this paper, the influence of different matrices on the effectiveness of confinement of masonry columns is investigated both experimentally and analytically. Three different matrices are considered to assemble the composite: a natural lime mortar with poor mechanical properties, a cement mortar, and a commercial mortar with high compression strength. The FRCM system was obtained by embedding a polyparaphenylenebenzobisoxazole fabric within these matrices. Results of axial compression tests demonstrate the effectiveness of confinement in all cases, highlighting the different increases in the load-bearing capacity and ductility of the columns provided by the use of different matrices. The main predictive formulas available in the literature were used to compute the increase in the load-bearing capacity of the tested columns, providing values very different than those obtained experimentally. For this reason, the authors believe that these formulas, which are affected by coefficients fine-tuned by the various authors based on their experimental results, need to be further calibrated and tuned to be successfully used in practical applications. Accordingly, the use of two different equations in the case of matrices having a compression strength higher or lower than the strength of the unconfined column is proposed
Experimental study on thermal matrix composite for seismic-energy upgrade of masonry buildings
No full textThe existing building stock consists mainly of masonry constructions built long before modern seismic regulations and the issue
of energy saving. As a result of the well-known problems related to climate change and the need to reduce energy consumption,
the issues of sustainability and reducing the environmental impact of the construction industry have become increasingly relevant.
In this context, the present research addresses an integrated way for both structural and energy upgrade of masonry buildings.
Specifically, innovative fibre-reinforced composite materials assembled by using lime-based thermal matrices combined with a
balanced high-strength basalt fibre were experimentally investigated at the Laboratory of the University of Florence. These
composite materials are identified by the acronym FRLM (Fiber Reinforced Lime Matrix). Initial work involved the selection of
thermally efficient and compatible matrices, and then, the composite materials were investigated through tensile tests and single
shear tests in order to evaluate their bond performance. Different bond lengths were considered with the goal of identifying the
effective one
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