1,953 research outputs found
An overview of the diagnostic and therapeutic use of monoclonal antibodies in medicine
No full textMonoclonal antibodies, which include murine, chimeric, humanised and fully human antibodies, bind to their target receptors with high affinity and specificity. In the last two decades several different monoclonal antibodies have been approved by the Food and Drug Administration for therapeutic purposes, and some of these and others have also been radiolabelled for diagnostic and therapeutic purposes. This field is in continuous evolution and this overview highlights the role of radiolabelled antibodies in research and clinical setting
On the Behavior of the Start and Stop System in European Real Driving Emissions Tests and Its Effect on Greenhouse and Tailpipe Emissions
No full textThe Start/Stop (S/S) system is a technology that switches off the engine without the intervention of the driver when the vehicle is stopped. The goal of this device is to eliminate the consumption of fuel associated with the idling of the engine and, consequently, save carbon dioxide (CO2) and pollutant emissions. However, its effectiveness is related to the percentage of the total driving time with the vehicle stopped. Moreover, even if the S/S system is installed and the vehicle is stopped, the S/S system can be inhibited by the condition of the vehicle like, for example, a too low state of charge of the battery. This investigation evaluates the actual effect of S/S on tailpipe gaseous emissions in Real Driving Emissions tests compliant with the new European Regulations (E-RDE). The investigation is based on data from on-road and on-track RDE tests performed with a Portable Emission Measurement System on a diesel sports utility vehicle (SUV). From the analysis of these data, the reduction of emission guaranteed by the S/S system was found to be quite lower than the potential in the New European Driving Cycle (NEDC) test due to the limited activation of the S/S system in real driving tests. Moreover, the analysis put into evidence that the saving associated with the S/S could be counterbalanced by the engine restart especially if the stop time is shorter than a certain threshold
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