929 research outputs found
Corrigendum to Patterns of ascending aortic dilatation and predictors of surgical replacement of the aorta: A comparison of bicuspid and tricuspid aortic valve patients over eight years of follow-up “J Mol Cell Cardiol. 2019 Oct;135:31–39. PMID: 31348923” (Journal of Molecular and Cellular Cardiology (2019) 135 (31–39), (S0022282819300495), (10.1016/j.yjmcc.2019.07.010))
No full textThe authors regret that the author name of Romano and Raffa are incorrect. The corrected author's name are Romano G and Raffa GM. The authors would like to apologise for any inconvenience caused
Ascending Aorta Resection and End-to-End Anastomosis: Redistribution of Wall Shear Stress Induced by a Bioprosthetic Heart Valve
No full textAlthough aortic resection and end-to-end anastomosis are applied to repair ascending aortic aneurysm, there is a lack of information on the late risk of post-operative complications, such as aortic dissection and aneurysmal re-dilatation. It is recognized that altered hemodynamic forces exerted on an aortic wall play an important role on dissection and aneurysm formation. We present a case in which the hemodynamic forces were investigated prior and after repair of an ascending aorta treated by resection with end-to-end anastomosis and a bioprosthetic heart valve. Post-operative wall shear stress was redistributed uniformly along the vessel circumference, and this may suggest a reduced risk of complications near aortic root, but not exclude the re-dilatation of the ascending aorta
Le paysage culturel de vignobles protégé par l’UNESCO et l’adaptation résiliente au changement climatique
No full text[EN] Viticulture has been particularly sensitive to climate changes throughout human history, building cultural landscapes of extraordinary beauty and highly adaptative to changes. But today, due to anthropogenic contribution, climate change is and will affect traditional vineyard cultural landscapes too, particularly those spread around the Mediterranean basin. The present acceleration to change and the need to adapt, is also challenging UNESCO and its advisory bodies positions, policies and conservation practices. In this shifting theoretical and operational framework, UNESCO vineyard cultural landscape have been investigated to understand the present on-field approach to climate adaptation. Particularly, it appears interesting the case study of UNESCO Prosecco Hills of Conegliano and Valdobbiadene that makes explicitly reference in its Management Plan to climate change as a threat. Through the identified case study and the advances in climate cultural heritage discourse, the contribution intends to open a reflection on UNESCO vineyard cultural landscapes’ adaptation to climate change, identifying some guidelines that could inform future adaptation process. At the end, an ongoing methodological experimentation of people-centered cultural mapping for adaptation project inside the Hills of Prosecco will be presented, stressing the urgency for more research on UNESCO vineyard cultural landscape.[CA] La viticultura ha sigut especialment sensible als canvis climàtics al llarg de la història de la humanitat, construint paisatges culturals d’extraordinària bellesa i molt adaptables als canvis. Però hui dia, a causa de la contribució antropogènica, el canvi climàtic està afectant i afectarà també els paisatges culturals tradicionals de la vinya, en particular als repartits per la conca mediterrània. L’actual acceleració del canvi i la necessitat d’adaptar-se, també està desafiant les posicions, les polítiques i les pràctiques de conservació de la UNESCO i els seus òrgans consultius. En aquest marc teòric i operatiu canviant, s’ha investigat el paisatge cultural de la vinya de la UNESCO per a comprendre l’enfocament actual sobre el terreny de l’adaptació al clima. En particular, resulta interessant el cas d’estudi de Prosecco Hills de Conegliano i Valdobbiadene de la UNESCO que fa referència explícita en el seu Pla de Gestió al canvi climàtic com a amenaça. A través de l’estudi de cas identificat i dels avanços en el discurs sobre el patrimoni cultural climàtic, la contribució pretén obrir una reflexió sobre l’adaptació dels paisatges culturals de les vinyes de la UNESCO al canvi climàtic, identificant algunes directrius que podrien informar el futur procés d’adaptació. Al final, es presentarà una experimentació metodològica en curs d’un projecte de cartografia cultural centrada en les persones per a l’adaptació dins dels Prosecco Hills, subratllant la urgència de realitzar més investigacions sobre el paisatge cultural de les vinyes de la UNESCO.[ES] La viticultura ha sido especialmente sensible a los cambios climáticos a lo largo del historia de la humanidad, construyendo paisajes culturales de extraordinaria belleza y altamente adaptables a los cambios. Pero hoy, debido a la contribución antropogénica, el cambio climático está afectando y afectará también a los paisajes culturales de los viñedos, particularmente a aquellos diseminados alrededor de la cuenca mediterránea. La actual aceleración del cambio y la necesidad de adaptarse suponen también un reto para la UNESCO y los posicionamientos de sus consejos asesores, políticas y prácticas de conservación. En este marco teórico y operacional cambiante, se ha investigado el paisaje cultural de viñedos protegidos por la UNESCO para comprender la adaptación actual al cambio climático in situ. En particular, resulta interesante el caso de estudio de la UNESCO en las colinas de Prosseco en Conegliano y Valdobbiadene que hace mención explícita en su Plan de Gestión del cambio climático como una amenaza. A través de este estudio de caso y de los avances en el discurso sobre clima y patrimonio cultural, este trabajo ambiciona iniciar una reflexión sobre la adaptación al cambio climático en los paisajes culturales de viñedos protegidos por la UNESCO, identificando algunas directrices útiles para futuros procesos de adaptación. Como conclusión, se presentará una experimentación metodológica que está en marcha sobre un proyecto de adaptación consistente en un mapeo cultural centrado en la población de las colinas de Prosseco, haciendo énfasis en la necesidad de más investigaciones en los paisajes culturales de viñedos protegidos por la UNESCO.[FR] La viticulture a été spécialement sensible aux changements climatiques tout le long de l’histoire de l’humanité, en construisant des paysages culturels d’une beauté extraordinaire et hautement adaptables aux changements. Aujourd’hui cependant, à cause de la contribution anthropogénique, le changement climatique est en train de compromettre et compromettra aussi les paysages culturels de vignobles, tout spécialement ceux dispersés autour du bassin méditerranéen. L’accélération actuelle de ce changement et le besoin d’adaptation supposent aussi un enjeu pour l’UNESCO et pour les positionnements de leurs comités consultatifs, leurs politiques et leurs pratiques de conservation. Dans ce cadre théorique et opérationnel en mutation, une recherche du paysage culturel de vignobles protégés par l’UNESCO a été réalisée afin de comprendre son adaptation actuelle au changement climatique in situ. Tout spécialement, il est intéressant d’observer l’étude de l’UNESCO sur les collines de Prosseco à Conegliano et Voldobbiadene, qui, dans son Plan de gestion du changement climatique considère celui-ci comme une menace. Moyennant cette étude de cas et des progrès dans le discours sur le climat et le patrimoine culturel, ce travail-ci a pour ambition d’inaugurer une réflexion sur l’adaptation au changement climatique dans les paysages culturels de vignobles protégés par l’UNESCO, identifiant quelques directrices utiles pour des processus d’adaptation à venir. Comme conclusion, une expérimentation méthodologique en cours y est présentée concernant un projet d’adaptation consistant en un mappage culturel centré sur la population des collines de Prosseco, en mettant l’accent sur la nécessité de plus de recherches sur les paysages culturels de vignobles protégés par l’UNESCO.Raffa, A. (2021). El paisatge cultural de les vinyes de la UNESCO i l’adaptació al canvi climàtic. ANUARI d’Arquitectura i Societat. 0(1):262-285. https://doi.org/10.4995/anuari.2021.16095OJS26228501Associazione per il Patrimonio dei paesaggi viti-vinicoli di Langhe-Roero e Monferrato. Relazione delle attività 2020. Alba, Italy 2020. www.paesaggivitivinicoliunesco.it. Access 2021 June 25.Associazione Colline di Conegliano Valdobbiadene Patrimonio dell'Umanità. Nomination Dossier Draft. Treviso, Italy, Grafiche Antiga, 2019. https://whc.unesco.org/en/list/1571/documents/, access 2021 June 25.Associazione Colline di Conegliano Valdobbiadene Patrimonio dell'Umanità. Management Plan. Treviso, Italy, Grafiche Antiga, 2019. https://whc.unesco.org/en/list/1571/documents/, access 2021 June 5.Basso, M. "From daily land-use practice to global phenomenon. On the origin and recent evolution of prosecco's wine landscape (Italy)." Miscellanea Geographica 22, no. 2 (July 2018). https://doi.org/10.2478/mgrsd-2018-0013, access 2021 June 5.Biagioli G., Prats M. e Bender, J. European guidelines for wine cultural landscape preservation and enhancement. INTERREG IVC, 2012. http://openarchive.icomos.org/1648/2/VITOUR_guide_EN.pdf, access 2021 June 5.Bonnuel, C. and Fressoz, J. La terra la storia e noi: l'evento antropocene. Roma: Treccani, 2019.Brabec, E., Chilton E.. "Towards an Ecology of Cultural Heritage." Change over Time 5, no. 2 (2015): 266-285. https://doi.org/10.1353/cot.2015.0021, Access 2021 June 5.Cassar, M., Young, C., Weighell, T., Sheppard, D., Bomhard, B., and Rosabal, P., Predicting and Managing the Effects of Climate Change on World Heritage. A Joint Report from the World Heritage Centre, Its Advisory Bodies, and a Broad Group of Experts to the 30th Session of the World Heritage Committee. Paris, France: UNESCO, 2006. http://whc.unesco.org/document/6670%20, access 2021 June 15.Crutzen, J. P.. Benvenuti nell'Antropocene: l'uomo ha cambiato il clima, la Terra entra in una nuova era. Milan, Italy, Mondadori, 2005.Fatorić, S., Seekamp, E.. "Are cultural heritage and resources threatened by climate change? A systematic literature review." Climatic Change. 142, no. 1-2 (2017): 227-254. https://doi.org/10.1007/s10584-017-1929-9. Access 2021 June 5.Guzman P., Fatorić S., Ishizawa M.. 'Monitoring climate change in World Heritage Properties: evaluating landscape-based approach in the State of Conservation system'[online]. Climate 8, no 3 (2020): 39-. https://doi.org/10.3390/cli8030039. Access 2021 June 5.Hannah L., Roehrdanz P.R., Ikegami M., Shepard A.V, Shaw R., Tabor G., Zhi L., Marquet P.A., Hijmans R.J.. "Climate change, wine, and conservation." In Proceedings of the National Academy of Sciences - PNAS 110, no. 17 (2013): 6907-6912. https://www.pnas.org/content/110/17/6907. Access 2021 June 05. https://doi.org/10.1073/pnas.1210127110Harvey D.C.. "Heritage and scale: settings, boundaries and relations." International Journal of Heritage Studies 19, no. 6 (September 2014): 577-93. https://doi.org/10.1080/13527258.2014.955812. Access 2021 June 5.Harvey, D., Perry, J.. The Future of Heritage as Climates Change: Loss, Adaptation an Creativity. New York and London, Routledge, 2015. https://doi.org/10.4324/9781315724164Holtorf, C.. "Embracing change: how cultural resilience is increased through cultural heritage." World Archaeology 50, no. 4 (September 2018): 639-650. https://doi.org/10.1080/00438243.2018.1510340. Access 2021 June 15.Icomos and Ifla. Principles concerning rural landscape as heritage. ICOMOS, New Delhi, 2017. https://www.icomos.org/images/DOCUMENTS/Charters/GA2017_6-3-1_RuralLandscapesPrinciples_EN_adopted-15122017.pdf. Access 2021 June 5.Markham, A. and Wiser, J.. "A Heritage Coalition's Call to Action on Climate Change and Cultural Heritage." Forum Journal 29, no. 4 (2015):19-23. http://muse.jhu.edu/journals/forum_journal/v029/29.4.markham.html. Access 2021 June 25.McClelland, A., Peel, D., Lerm Hayes, C. and Montgomery, I.. "A Values-based Approach to Heritage Planning: Raising Awareness of the Dark Side of Destruction and Conservation." The Town Planning Review 84, no. 5 (2021): 583-603. http://www.jstor.org/stable/24579196. Access 2021 June 15. https://doi.org/10.3828/tpr.2013.31McNeil, J. and Engelke, P.. La grande accelerazione: una storia ambientale dell'antropocene dopo il 1945. Turin, Einaudi, 2018.O'Brien, K. and Wolf, J.. "A values-based approach to vulnerability and adaptation to climate change." Wiley Interdisciplinary Reviews: Climate Change 1, no. 2 (march 2010): 232-242. https://doi.org/10.1002/wcc.30. Access 2021 June 15.Icomos. The Future of Our pasts. Engaging cultural heritage in climate action [online]. Paris, Icomos, 2019. https://www.icomos.org/fr/themes-dactualite/changement-climatique/59544-icomosreleases-future-of-our-pasts-report-to-increase-engagement-of-cultural-heritage-inclimate-action-2 Access 2021 June 15.Labadi, S.. UNESCO, cultural heritage, and outstanding universal value: value-based analyses of the world heritage and intangible cultural heritage conventions. Lanham, US, Altamira Press, 2013.Lallanilla, M.. "Will Global Warming Crush the Wine Industry?" Live Science, (9 April 2013). http://www.livescience.com/28577-wine-global-warming.html. Access 2021 June 05.Pappalardo, S., Gislimberti, L., Ferrarese, F., De Marchi, M., Mozzi, P.. "Estimation of potential soil erosion in the Prosecco Docg area, toward a soil footprint of bottled sparkling wine production in different land-management scenarios." PLoS ONE 14, no. 5 (May 2019). https://doi.org/10.1371/journal. pone.0210922. Access 2021 June 15.Raffa, A.. Il paesaggio culturale dell'Antropocene. Le Colline del Prosecco di Conegliano e Valdobbiadene come possibile laboratorio nel quadro delle politiche UNESCO = Final Research report. Treviso, Italy Fondazione Benetton Studi Ricerche, 2020. https://www.fbsr.it/wp-content/uploads/2021/05/AlessandroRaffa_PAPER.pdf.Rockman, M., and Maase, J.. "Every Place has a Climate Story: Finding and Sharing Climate Change Stories with Cultural Heritage." In Public Archaeology and Climate Change. Ed. Dawson, T., Nimura, C., López‐Romero, E., and Daire, M. Y., Oxford, Oxbow Books, 2017. https://doi.org/10.2307/j.ctvh1dp4n.16Seekamp, E., Jo, E.. "Resilience and transformation of heritage sites to accommodate for loss and learning in a changing climate." Climatic Change 162, no. 1(August 2020): 41-55. https://doi.org/10.1007/s10584-020-02812-4. Access 2021 June 15.Sesana, E., Gagnon, A., Bertolin, C., Hughes, J.. "Adapting cultural heritage to climate change risks: perspectives of cultural heritage experts in Europe." Geosciences 305, no. 8 (August 2018). https://doi.org/10.3390/geosciences8080305. Access 2021 June 15.Smith, L.. The uses of heritage. London and NY, Routledge, 2006 · UNESCO. World Heritage Thematic Expert Meeting on Vineyard Cultural Landscapes. Paris: UNESCO World Heritage Committee, 2001. https://unesdoc.unesco.org/ark:/48223/pf0000126498. Access 2021 June 15.UNESCO. Policy for the Integration of a Sustainable Development Perspective into the Process of the World Heritage Convention. Paris, World Heritage Centre, 2015. https://whc.unesco.org/document/139146+&cd=3&hl=it&ct=clnk&gl=it. Access 2021 June 15.UNESCO. Operational Guidelines for the implementation of the World Heritage Convention. Paris,UNESCO World Heritage Centre, 2019. https://whc.unesco.org/en/guidelines. Access 2021 June 15
Il canto di Achille :(Ps. Plut. De Mus.40, 1145 D-F)
No full textThe author of the De musica recalls a popular scene from the fliad - Achilles singing
heroic verses on his Iyre - to show what kind of music is appropriate far a hero.
This paper provides an inquiry into the compìler's possible sources, taking ìnto
account the philosophical debate on anger and on musical ethos in general. The
mention of Chiron as Achìlles' music teacher is also particularly meaningful with
reference to the piace of music in the so-called enkyklios paideia
Circulating leukocytes and oxidative Stress in cardiovascular diseases: a state of the art
No full textIncreased oxidative stress from both mitochondrial and cytosolic sources contributes to the development and the progression of cardiovascular diseases (CVDs), and it is a target of therapeutic interventions. The numerous efforts made over the last decades in order to develop tools able to monitor the oxidative stress level in patients affected by CVDs rely on the need to gain information on the disease state. However, this goal has not been satisfactorily accomplished until now. Among others, the isolation of circulating leukocytes to measure their oxidant level offers a valid, noninvasive challenge that has been tested in few pathological contexts, including hypertension, atherosclerosis and its clinical manifestations, and heart failure. Since leukocytes circulate in the blood stream, it is expected that they might reflect quite closely both systemic and cardiovascular oxidative stress and provide useful information on the pathological condition. The results of the studies discussed in the present review article are promising. They highlight the importance of measuring oxidative stress level in circulating mononuclear cells in different CVDs with a consistent correlation between degree of oxidative stress and severity of CVD and of its complications. Importantly, they also point to a double role of leukocytes, both as a marker of disease condition and as a direct contributor to disease progression. Finally, they show that the oxidative stress level of leukocytes reflects the impact of therapeutic interventions. It is likely that the isolation of leukocytes and the measurement of oxidative stress, once adequately developed, may represent an eligible tool for both research and clinical purposes to monitor the role of oxidative stress on the promotion and progression of CVDs, as well as the impact of therapies
Museo-Laboratorio Appia Antica. Sperimentazioni progettuali nel solco di una tradizione di grande bellezza
No full textStarting from a reflection on the Appia Antica as a palimpsest of great beauty, the contribution aims at highlighting the unique experimental design tradition based on the understanding and enhancement of the antique, shaped over time along its path. In the wake of this tradition, based on the direct exploration of places, the educational activities promoted by the Accademia Adrianea di Architettura e Archeologia look at the Regina Viarum as an extraordinary laboratory in which students and scholars can investigate through design the widespread dimension of contemporary design
Computational fluid dynamics of the ascending aorta before the onset of type A aortic dissection
No full textWe performed a pre-dissection computational fluid analysis of an ascending aortic aneurysm associated with unicuspid aortic valve. The analysis showed an abnormal helical flow pattern inside the aneurysm and an increased wall stress on the right postero-lateral wall of the ascending aorta. These values were largely higher than the theoretical cut-off for aortic wall dissection, their topographic distribution followed the intimal tear site as subsequently diagnosed by computed tomography scan and confirmed during the operation for dissection repair
Amiodarone-induced pulmonary toxicity with an excellent response to treatment
No full textAmiodarone is an anti-arrhythmic drug widely used, but its administration can be associated with several adverse side-effects. Among these, amiodarone-induced pulmonary toxicity (APT) occurs in 4-17% of cases and, if not early diagnosed and treated, may evolve towards pulmonary fibrosis and respiratory failure. A 76 years-old-man went to the hospital for accidental trauma. The patient did not report respiratory symptoms but was suffering from atrial fibrillation treated with amiodarone 200 mg/day from three years (cumulative dose >150 gr). HRCT showed ground-glass opacities and nodules in both lungs. The patient underwent fibreoptic bronchoscopy with BAL. Cytologic examination of BALF sediment put in evidence foamy macrophages. The electronic microscopy revealed into the alveolar macrophages "... the presence of multilamellar intracytoplasmic bodies and lysosomes, loads of lipid material". LFTs showed a restrictive syndrome and an impairment of DLCO. Amiodarone discontinuation and steroid administration led to the regression of radiological lesions and the recovery of lung function. Patients taking amiodarone can experience APT. They should perform a basal chest x-ray with LFTs before starting therapy. Monitoring could reveal early the pulmonary toxicity, and patients can respond favourably to the treatment
- …
