23 research outputs found

    Asymmetric Syntheses of Medicinally Important Isoindolinones (<i>S</i>)‑PD 172938, (<i>R</i>)‑JM 1232, and Related Structures

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    A unified approach for the asymmetric syntheses of medicinally important isoindolinones (S)-PD 172938 and (R)-JM 1232 has been accomplished via a Cu­(I)-PYBOX-diPh catalyzed highly enantioselective (up to 99% ee) alkynylation/lactamization sequence in a one-pot fashion. The overall sequence involves one C–C and two C–N bond forming events in one pot starting from inexpensive starting material in ambient reaction conditions

    Double burden of malnutrition among urban Bengalee adolescent boys in Midnapore, West Bengal, India

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    Malnutrition is an important public health problem worldwide. Therefore a study was undertaken to assess the prevalence of adolescent thinness, overweight and obesity in Midnapore town, West Bengal, India. A total of 974 adolescent boys aged 10-18 years were selected following multistage cluster sampling method from three higher secondary schools. Data was collected using pretested questionnaire following standard technique. Presence of thinness was evaluated using the cut-off values of international survey as suggested by Cole et al (2007). While overweight and obesity was determine by using international cut-off values develop by Cole et al (2000) based on international surveys as recommended by IOTF. Overall the prevalence of thinness, overweight and obesity were 20.8%, 14.9% and 3.8%, respectively. This study developed age specific smooth BMI percentile values using LMS method. Moreover, the study also developed BMI cut-off values to define thinness, overweight and obesity. In conclusion, the present analyses indicated that the prevalence of adolescent undernutrition is still a major problem. In addition, there was also an emerging trend for overweight/obesity, thereby indicating a double burden of malnutrition as observed in other developing countries

    Solute-Solvent Interaction in Aqueous PEG Solution

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    Department of Chemistry, Jadavpur University, Calcutta-700 032 Manuscript received 14 December 1992 The hydration and solute—solvent interaction parameters of five polyethylene glycols PEG 200, 300, 400, 600 and 1000, have been reported. The hydration has been unambiguously evaluated using conductance and viscosity methods. A comparison of the important literature cited hydrations of EO group with the results of this study has been made. The viscosity B and C coefficients have been obtained from a quadratic fitting of relative viscosity with mol dm concentration of the PEG. The B coefficient has been analysed in the light of molecular size, solvation and water—structure modification. The solute—solute interaction parameter C has been observed to be significant for PEG 600 and 1000. The results are more consistent than that reported by Bahri and Guveli given in reference seventeen

    Critical nutritional stress among adult tribal populations of West Bengal and Orissa, India.

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    This paper deals with cross-sectional studies carried out during the period 2004-2007. It is based on eight data sets of tribals of Paschim Medinipur and Bankura Districts of West Bengal and Keonjhar District of Orissa. The tribes include Bhumijs, Kora Mudis, Lodhas, Santals, Bathudis and Savars. Height and weight were measured following standard techniques. The body mass index (BMI) was computed following standard equation. Nutritional status (chronic energy deficiency, CED) was evaluated using internationally accepted cut-off values of BMI. We followed the World Health Organization&#x27;s classification (1995) of the public health problem of low BMI, based on adult populations worldwide. Our results show that, in general, among the tribes studied:&#xd;&#xa;i)Both sexes had very low levels of BMI&#xd;&#xa;ii)There existed high rates of CED indicating a critical nutritional condition &#xd;&#xa;iii)Women experienced greater nutritional stress&#xd;&#xa;iv)The nutritional situation is similar in both West Bengal as well as Orissa.&#xd;&#xa

    Nutritional Status of Adolescent Girls from Rural Communities of Tigray, Northern Ethiopia

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    Background: Addressing the nutritional needs of adolescents could be an important step towards breaking the vicious cycle of intergenerational malnutrition. Objective: Assess nutritional status of rural adolescent girls. Design: Cross-sectional. Methods: Anthropometric and socio-demographic information from 211 adolescent girls representing 650 randomly selected households from thirteen communities in Tigray was used in data analysis. Height-for-age and BMI-for-age were compared to the 2007 WHO growth reference. Data were analyzed using SAS, Version 9.1. Results: None of the households reported access to adolescent micronutrient supplementation. The girls were shorter and thinner than the 2007 WHO reference population. The cross-sectional prevalence of stunting and thinness were 26.5% and 58.3%, respectively. Lack of latrine facilities was significantly associated with stunting (p = 0.0033) and thinness (p <0.0001). Age was strong predictor of stunting (r(2) = 0.8838, p <0.0001) and thinness (r(2) = 0.3324, p <0.0001). Conclusion: Undernutrition was prevalent among the girls. Strategies to improve the nutritional status of girls need to go beyond the conventional maternal and child health care programs to reach girls before conception to break the intergenerational cycle of malnutrition. Further, carefully designed longitudinal studies are needed to identify the reasons for poor growth throughout the period of adolescence in this population. [Ethiop. J. Health Dev. 2009; 23(1):5-11

    Formation of a density blob and its dynamics in the edge and the scrape-off layer of a tokamak plasma

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    Formation of a density blob and its motion in the edge and scrape-off layer (SOL) of a tokamak plasma have been simulated using two-dimensional, two-field, fluid model equations. The simulation results show that density blobs form in the edge or in the edge-to-SOL transition region where the poloidal velocity shear is maximum. From the numerical data, a condition for density blob formation has been obtained. Dynamics of the detached blob in the edge and SOL regions has been studied. It is observed that not all the blobs that form in the edge or edge-to-SOL transition region are capable of ejection deep into the SOL. A condition for their ejection is also discussed. Radial particle transport associated with the blobs in the SOL has been calculated. It is found that about 60% of the total radial particle flux is carried out by these blobs
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