1,721,165 research outputs found
LOWER EFFICACY - INTERACTION WITH AN INHIBITORY RECEPTOR OR PARTIAL AGONISM
No full textIt is very common in practice to find that some concentration-response curves are 'bell shaped', and this phenomenon also applies to partial agonist curves. On the basis of these considerations, a mathematical model has been developed for the interaction of a ligand with two different receptors that mediate opposite effects (one stimulatory and one inhibitory), and is discussed in this article by Enrico Rovati and Simonetta Nicosia. This model can account for both an apparent reduction in efficacy and the curvature of the upper plateau of some concentration-response curves. Therefore, under certain conditions, an agonist that also interacts with an inhibitory receptor might be mistaken for a partial agonist, unless the concentration-response curves are performed over the widest possible range of concentrations
A stochastic comparison algorithm for the control of non-stationary discrete event systems
No full textDynamic modelling of a two link flexible robot and experimental validation
No full textThe paper discusses the modelling issues for a two link flexible robot arm. The exact dynamic model of the robot arm is derived, and approximate forms suitable for the analysis and control design are proposed. The approach used here to derive an approximate finite dimensional model of the flexible robot arm is based on the Ritz expansion method. Simulations and experimental tests have been carried out to validate the approximate dynamic model of the robo
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