334 research outputs found
AIQUA WORKSHOP: UPDATES ON THE CHRONOLOGY, STRATIGRAPHY AND ENVIRONMENTS OF THE LAST GLACIAL MAXIMUM AND THE LATE GLACIAL ON THE SOUTHERN SIDE OF THE ALPS
No full textThe AIQUA workshop, sponsored by the TERPRO and SACCOM INQUA Commissions and by the IGG-CNR and the Department of Geosciences of the University of Padova, was held at the Department of Geosciences of Padova, on June 22nd-23nd, 2017 (scientific and organizing committee: P. Mozzi, G. Monegato, A. Fontana, S. Rossato). The workshop focused on the geomorphic, sedimentary and palaeoenvironmental events that occurred in the southern Alpine region and related Po Plain, Venetian-Friulian Plain and Adriatic basin during the Last Glacial Maximum and the Late Glacial. About 60 participants attended the workshop, with nine solicited talks, five short communications and posters, and ample time devoted to discussion. The second day consisted in a field trip in the Venetian Prealps
All’ombra della grammatica: una silloge poetica quasi ignota e un ‘nuovo’ autore (ms. Macerata, Biblioteca Comunale “Mozzi-Borgetti”, 662)
No full textThis paper focuses on the corpus of twenty three Latin poems held in the ms. Macerata, Biblioteca Comunale “Mozzi Borgetti”, 662, copied in 1481 by a certain Giovan Pietro di ser Gabriele from Cingoli (according to the subscription) and to be surely considered as a school book. It is one of the few surviving manuscript witnesses of the Artis grammatice opusculum arranged by Bartolomeo Filalite, pupil of Lorenzo Valla. The carmina (ff. 54r-63r) - adespoti, anepigraphic and never studied so far - are interesting for their recipients, content and structure. The essay sheds new light on their author, on their addressees (including important personalities such as the cardinal Raffaele Riario) and offers assessments of their contents; actually, although the text is strongly compromised by errors (linguistic, syntactic and metrical), it gives relevant information, in particular about the relationship between the author and Pomponio Leto. Such considerations allow us to reconstruct an interesting piece of the network system of the Italian Humanism; but also they allow us to follow the development of Latin poetry in the second half of the Quattrocento, which became a practised and practicable 'language' on a wide scale: a clear sign of the functioning and quality of the educational system
An LC-MS Assay with Isocratic Separation and On-Line Solid Phase Extraction to Improve the Routine Therapeutic Drug Monitoring of Busulfan in Plasma
No full textBackground: Busulfan (Bu) requires therapeutic drug monitoring (TDM) in subjects undergoing a conditioning regimen for hematopoietic stem cell transplantation (HSCT). To speed up the procedure and increase reproducibility, we improved our routine LC-MS/MS assay using the on-line solid-phase extraction (SPE) of samples. Methods: A protein precipitation (PP) step was performed before the on-line SPE of Bu from 200 μL of plasma spiked with octa-deuterated Bu (D8-Bu) as the internal standard. Bias was assessed with respect to our routine LC-MS/MS Bu assay with off-line extraction using the Passing-Bablok robust regression. Root cause of bias for individual samples was assessed by analyzing the regression residuals. Results: The method was linear in the range 37.75-2,416 ng/mL (r2>0.999), with 19.74 ng/mL LLOQ and 10.5% CV at 20 ng/mL. Precision and accuracy were both within ±5%, and neither appreciable matrix nor carryover effects were observed. The Passing-Bablok regression analysis returned a 0.99 slope (95% Cl: 0.97 to 1.01) and -6.82 intercept (95% Cl: -15.23 to 3.53). Residuals analysis against the 2.5th-97.5th percentiles range showed four samples with significant bias individually. Conclusions: The method presented can be successfully employed for the routine analysis of Bu in plasmatic samples, and can replace the LC-MS/MS method with off-line extraction without any statistically significant overall bias. In this regard, samples with individual significant bias were reasonably produced by preanalytical issues which had no relation with the conversion to the on-line SPE extraction
Il contesto geomorfologico, in Ghedini S., Busana S. (a cura di) – Indagine Ambientale Storico-Archeologica nella tenuta di Ca’ Tron (Roncade-Treviso/Meolo-Venezia).
No full textInvestigating evidences of Quaternary glaciations in the Prealpine environment of the Astico valley
No full textIn the Astico valley (Venetian Prealps) some glacial, fluvioglacial and glaciolacustrine deposits were found. They are attributed to a pre-LGM glacial advance which reached further out in the valley. Geomorphological and stratigraphic data support this hypothesis. It is also pointed out the presence of a tectonic guidance in the developing of the Astico fluvial network
Un ulteriore passo verso una migliore efficienza ed efficacia della determinazione della calprotectina fecale
No full textAppropriateness of tumor marker (TM) ordering after application of local guidelines (LG) : do not loose the control
No full textTumor marker odering: do not lose control : a prospective clinical trial
No full textObjectives: In this study, we evaluated the extent of inappropriate tumor marker (TM) ordering in a secondary care setting, approximately 6 years after the introduction of local guidelines, and we identified the main factors potentially influencing clinicians when performing an inappropriate TM request.
Methods: For this purpose, we regularly checked all requests containing more than two TMs. During the 21-month audit, the rate of rejected requests amounted to 3.6%. Several of those were performed for diagnostic purposes. The most frequent and inappropriately requested TMs were carcinoembryonic antigen and carbohydrate antigen 19.9.
Results: The inappropriateness of requests appeared to be linked to the need for more education and knowledge on their clinical applicability and limitations. The clinical motivation was generally associated with patients displaying nonspecific signs/symptoms (ie, weight loss with worsening general conditions), having an incidentally positive result to some recently performed TM tests, or being tested by a TM to avoid more expensive diagnostic imaging procedures.
Conclusions: Our data show that real-time control and management of inappropriate requests by laboratory professionals may be relevant to increase the clinical
efficacy of TM testing and useful in perspective to drive the introduction of new validated biomarkers
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