4,866 research outputs found
Un'archeologia dell'autofinzione italiana: Guido Piovene
No full textthe article inquires the notion of autofiction backdating its application to the Italian writer Guido Piovene. After a short theoretical introduction on the early Italian debate around autofiction, the article retraces the evolution of the strategies for self-fictionalization in Piovene's work through the decade
"Una coppia di serpenti allacciati". L'incesto nelle "Benevole" di Jonathan Littell
No full textThe article reads the novel "The Kindly Ones" (2006) by French author Jonathan Littell and focuses on the issue of incest displayed in the plot
Dysphagia in neurological diseases: a literature review. Panebianco M, Marchese-Ragona R, Masiero S, Restivo DA. Neurol Sci. 2020 Jun 7. doi: 10.1007/s10072-020-04495-2.
No full textDysphagia is defined as an impairment of this complex and integrated sensorimotor system. It is estimated that 400,000 to 800,000 individuals worldwide develop neurogenic dysphagia per year. Neurogenic dysphagia is typically occurring in patients with neurological disease of different etiologies. A correct and early diagnosis and an appropriate management of dysphagia could be useful for improving patient’s quality of life and may help to prevent or delay death. In the present review, we discuss thoroughly the anatomy and physiology of swallowing and also the pathophysiological mechanisms involved in impaired swallowing, as well as the diagnosis, management, and potential treatments of neurogenic dysphagia. Assessment of neurogenic dysphagia includes medical history, physical exam, and instrumental examinations (fiberoptic endoscopic evaluation of swallowing, videofluoroscopic swallowing study, electromyography). Pharmacological treatment of these problems includes oral anticholinergic drugs. Surgical myotomy of the cricopharyngeal muscle showed an important improvement of oropharyngeal dysphagia associated to upper esophageal sphincter hyperactivity. Chemical myotomy of the upper esophageal sphincter by local injections of botulinum toxin type A into the cricopharyngeal muscle has been proposed as an alternative less invasive and less unsafe than surgical myotomy
Adsorption of sulfonamide antibiotics onto high silica zeolites: from multidisciplinary model studies to applications to real waters
No full textOwing to their environmental diffusion and persistence, sulfonamide antibiotics (sulfa drugs) are
responsible to induce high level of resistance in bacteria. The sulfonamide anionic nature makes them
highly mobile along soil profile and is responsible for their accumulation into water bodies. In order
to limit the diffusion of resistance determinants, it is of utmost importance to identify adsorbents for
this antibiotic family to be adopted for water cleanup purpose. Three high silica zeolites (Y, MOR,
ZSM-5) have been tested for their capability to extract sulfonamides from water. Kinetics, capacity
and reversibility of the adsorption have been studied along with sulfonamide arrangement into the
porosities of each zeolite [1-3].
The sulfa drugs irreversibly adsorbed onto zeolite Y at ca. 26% on average and with the process
equilibrium reached in less than 1 min [1,3]. The favorable adsorption kinetics was confirmed when
zeolite Y was applied to both fresh and sea waters although the dissolved organic matter occurring
in natural water compartments can be retained as well but with a kinetics less favorable than that
shown by sulfa drugs. The main host-guest & guest-guest interactions between zeolites and sulfa drugs
were defined by IR and SS-NMR analysis, and augmented by computational studies. H-bonds and van
der Waals type interactions between single molecules and zeolite Y or ZSM-5 were responsible for
the irreversible extraction of sulfa drugs from water [1,3]. The occurrence of intramolecular medium
strength H-bond in small sized sulfa drugs upon adsorption inside zeolite Y cage revealed the formation
of dimeric species whose amidic or imidic tautomeric form were identified [1,3]. Rietveld refinement
and IR analysis revealed that sulfa drugs incorporation into MOR caused a close vicinity of the
heterocycle ring to the side pocket oxygens [2,3]. At 65°C, MOR gave rise to a sulfachloropyridazine
reaction product with a 100% selectivity and SNAr mechanism [2]. Among the regeneration strategies
approached, the thermal treatment and solvent extraction gave the best results.
References
[1] I. Braschi, G. Paul, G. Gatti, M. Cossi, L. Marchese. RSC Advances, 3, 7427 (2013).
[2] A. Martucci, M.A. Cremonini, S. Blasioli, L. Gigli, G. Gatti, L. Marchese, I. Braschi. Micropor.
Mesopor. Mat. 170, 274 (2013).
[3] S. Blasioli, A. Martucci, G. Paul, L. Gigli, M. Cossi, C.T Johnston, L. Marchese. J. Coll. Interface.
Sci., 419, 148 (2014)
Attività antibatterica di N-acetilcisteina sui principali patogeni responsabili di infezioni delle alte vie respiratorie e sui germi del cavo orale.
No full textAttività antibatterica di N-acetilcisteina sui principali patogeni responsabili di infezioni delle alte vie respiratorie e sui germi del cavo orale
No full textA. Zecchina, L. Marchese, S. Bordiga, C. Pazè, E. Gianotti Vibrational Spectroscopy of NH4+ Ions in Zeolitic Materials: an IR Study.
No full text67.11 / Al signor marchese Ridolfo del S. R. I. conte Colloredo…per le sue nozze
No full textAl signor marchese Ridolfo del S. R. I. conte Colloredo…per le sue nozz
Activity of daptomycin on biofilms produced on a plastic support by Staphylococcus spp.
No full textThe aim of this study was to assess whether the novel lipopeptide daptomycin might be capable of disrupting or inhibiting the synthesis of biofilms produced by staphylococci. Fourteen recently isolated slime-producing methicillin-susceptible (MET-S) and methicillin-resistant (MET-R) strains (three MET-S Staphylococcus aureus, three MET-R S. aureus, three MET-S Staphylococcus epidermidis, three MET-R S. epidermidis and two vancomycin-intermediate S. aureus (VISA)) were tested. Slime formation on polystyrene plates was quantified spectrophotometrically. Daptomycin(2-64 mg/L) inhibited slime synthesis by > or =80% in MET-S strains, by 60-80% in MET-R S. aureus and by 70-95% in MET-R S. epidermidis. At 64 mg/L, biofilm synthesis decreased by 80% in the VISA isolates. Daptomycin also disrupted pre-formed biofilm: >50% breakdown of initial biofilm (5h) was observed in all strains. Disruption of mature biofilms (48 h), in terms of percentage, was more variable depending on the strain, ranging from ca. 20% in a MET-R S. epidermidis strain to almost 70% in two MET-S strains (one S. aureus and one S. epidermidis). Daptomycin at concentrations achievable during therapy promoted a statistically significant inhibition of slime synthesis (preventing biofilm building) and induced slime disruption (disaggregating its structure) both in initial and mature biofilms on a plastic support in all staphylococcal strains studied
- …
