828 research outputs found
Doctor Ivan Lutsenko: myths and facts
No full textНа основе архивных данных, впервые введенных в научный оборот автором, а также критического анализа литературы прослеживается жизненный путь доктора медицины Ивана Митрофановича Луценко (1864–1919), который вошел в историю как активный деятель эпохи гражданской войны на Украине. Автор полемизирует с теми историками, которые видят в Луценко героя, «украинца нового типа», и обосновывает точку зрения, согласно которой И.М. Луценко – украинский ультранационалист, русофоб и антисемит.Based on the data from the archives, which the author is first to introduce to the scientific circulation, and a critical analysis of the literature, we observe the life’s journey of a medical doctor Ivan Mitrofanovich Lutsenko (1864–1919), whom history presents as an active figure in the epoch of the civil war in Ukraine. The author polemicizes with the historians, who see Lutsenko as a hero, “a new kind of Ukrainian”, and substantiates a point of view according to which, I. M. Lutsenko is an ultranationalist, Russophobe and an anti-Semite
Il caso Lutsenko davanti alla Corte europea dei diritti dell'Uomo
No full textPubblichiamo un breve resoconto dell'udienza tenutasi il 17 aprile 2012 davanti alla Corte europea dei diritti dell'uomo, relativa al procedimento "Lutsenko c. Ucraina". La vicenda riguarda l'ex ministro dell'Interno e attuale leader dell'opposizione in Ucraina, detenuto dal dicembre 2010 per alcuni episodi di abuso di ufficio. Il ricorrente lamenta di essere vittima di repressione politica e chiede che la Corte riconosca la violazione dell'art. 5 Cedu (diritto alla libertà ed alla sicurezza) e la violazione dell'art. 18 Cedu (in materia di tassatività delle restrizioni dei diritti sanciti dalla Cedu), quest'ultima fino ad oggi pronunciata in un unico caso
Strumok stream cipher: Specification and basic properties
No full textSTRUMOK is a word-oriented additive stream cipher, where a word in the specification is chosen to be 64 bits. STRUMOK cipher uses some basic design principles from the stream cipher SNOW 2.0. STRUMOK aims at improving SNOW 2.0 both from the security and from the efficiency points of view. Most notably, it uses a more productive keystream generation procedure
Carbon isotopes separation in plasmachemical reactor: Axial distribution of discharge characteristics
No full textSingle nucleotide polymorphisms in the human ATP7B gene modify the properties of the ATP7B protein
No full textSingle nucleotide polymorphisms (SNPs) are the largest source of sequence variation in the human genome. However, their functional significance is not well understood. We show that SNPs in the Wilson disease gene, ATP7B, that produce amino-acid substitutions K832R and R952K, modulate ATP7B properties in vitro and influence serum copper (Cu) status in vivo. The presence of R832 is associated with a lower ATP7B abundance and a diminished trafficking in response to elevated Cu. The K832R substitution alters surface exposure of amino acid residues in the actuator domain and increases its conformational flexibility. All SNP-related ATP7B variants (R832/R952, R832/K952, K832/K952, and K832/R952) have Cu-transport activity. However, the activity of ATP7B-K832/K952 is lower compared to other variants. In humans, the presence of K952 is associated with a higher fraction of exchangeable Cu in serum. Thus, SNPs may modulate the properties of ATP7B and the organism Cu status
Data associated with the publication: Functional screen of Wilson Disease ATP7B variants
No full textThe current dataset includes the the associated data such as microscopy images, data quantification and detailed visual summaries to the article Functional Screen of Wilson Disease ATP7B Variants Reveals Residual Transport Activities. Calvo, J. S.; Heger, T.; Kabin, E.; Mowrey, W.R.; Del Angel, G.; Ding, W.; Lutsenko, S. Human Mutation, 2025 (1).
This investigator-initiated project is funded through an externally sponsored research agreement with Alexion, AstraZeneca Rare Disease (Boston, MA, United States). T.H. was supported by the Boehringer Ingelheim Fonds travel grant, the Lundbeck Foundation, and the Department of Molecular Biology and Genetics, Aarhus University, Denmark
The research of modern stream ciphers
No full textSynchronous stream ciphers produce long keystreams to be XORed with plaintext. The output keystreams should be indistinguishable from truly random sequences and should not leak any information about the secret key and the internal state of the cipher. In this study, we analyze of modern stream ciphers according to various criteria using methodology eSTREAM
Defective cellular localization of mutant ATP7B in Wilson's disease patients and hepatoma cell lines
No full textBackground & Aims: Wilson's disease, a hereditary disorder caused by mutations in the Wilson's disease gene (ATP7B), leads to hepatic and/or neurological pathology resulting from cellular copper overload. In vitro studies showed that ATP7B, located in the trans-Golgi network, traffics to a cytoplasmic vesicular compartment in response to increased copper concentration. Mislocalization and failed intracellular trafficking of ATP7B mutants are suggested to be among disease-causing mechanisms; however, the effect of mutations on ATP7B localization in human tissues has not been directly shown. Therefore, we characterized the subcellular localization of normal and mutant ATP7B in human livers and in hepatoma cell lines. Methods: Subcellular distribution of ATP7B in liver tissue from 3 control individuals and 3 Wilson's disease patients harboring a homozygous H1069Q-ATP7B mutation was analyzed by using immunogold electron microscopy. In addition, 14 ATP7B mutants tagged to green fluorescent protein were generated and expressed in HuH-7 and HepG2 cells; intracellular localization of these mutants was characterized by confocal microscopy. Results : In hepatocytes, ATP7B was localized in trans-Golgi vesicles, whereas H1069Q-ATP7B was trapped in the endoplasmic reticulum. Similar results were observed for wild-type ATP7B and H1069Q-ATP7B expressed in hepatoma cells. Most ATP7B proteins harboring missense mutations were distributed similarly to wild-type ATP7B. In contrast, truncated ATP7B mutants showed a diffuse, clustered, cytoplasmic pattern, distinct from the trans-Golgi network or endoplasmic reticulum. Conclusions: These results provide a detailed demonstration of the ATP7B distribution in control and diseased human livers and indicate that several Wilson's disease mutations lead to incorrect localization of ATP7B to distinct cell compartments
NIST PQC: Code-based CryptoSystems*
No full textThe code-based schemes, which were submitted to the contest of post-quantum crypto algorithms NIST PQC, are studied in this work. The general characteristics of the algorithms are explored and basic properties and parameters are estimated. A comparative analysis of the electronic digital signature schemes, public-key cryptosystems and key encapsulation schemes are carried out according to the criteria of speed and length of the main cryptographic parameters
Code-based cryptosystems from NIST PQC
No full textIn this paper we research code-based electronic digital signature schemes, which ware submitted to the contest of post-quantum crypto algorithms NIST PQC. There are explored general characteristics of the algorithms and basic properties and parameters estimated. Also we carried out comparative analysis of the electronic digital signature schemes and public-key cryptosystems according to the criteria of speed and length of the main cryptographic parameters
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