411 research outputs found
The effect of puberty on insulin resistance in obese children.
No full textJ Endocrinol Invest. 2009 May;32(5):401-5.
The effect of puberty on insulin resistance in obese children.
Pilia S, Casini MR, Foschini ML, Minerba L, Musiu MC, Marras V, Civolani P, Loche
S.
Pediatric Endocrinology Unit, Microcitemico Hospital, ASL Cagliari, Cagliari,
Italy.
OBJECTIVE: Insulin resistance (IR) increases during puberty in normal children.
IR is the first adverse metabolic event of obesity, and the marker of the
metabolic syndrome. We aimed to study the effect of puberty on IR in obese and
normal-weight children.
DESIGN: Cross-sectional evaluation of fasting glucose, insulin concentrations,
and homeostasis model assessment of IR (HOMA-IR) in obese and control children
throughout puberty.
PATIENTS AND METHODS: We recruited 424 obese children (207 pre-pubertal and 217
pubertal divided in Tanner stages 2-3, 4, and 5) and estimated IR using the
HOMA-IR index. Data were compared to those obtained in 123 healthy normal-weight
children (40 pre-pubertal and 83 pubertal divided in Tanner stages 2-3, 4, and
5).
RESULTS: In the obese children mean HOMA-IR increased progressively across Tanner
stages, and was significantly higher in all groups (pre-pubertal and Tanner
stages 2-3, 4, and 5) of obese than in control children. HOMA-IR was
significantly correlated with BMI.
CONCLUSIONS: HOMA-IR in obese children increases at puberty more than in
normal-weight children and does not return to pre-pubertal values at the end of
puberty.
PMID: 19794287 [PubMed - indexed for MEDLINE
Vingt-huitième marque pharmaceutique : S. Letellier et « l’Eau ophtalmique de Loche » [R 248 Marques pharmaceutiques]
No full textRaynal Cécile. Vingt-huitième marque pharmaceutique : S. Letellier et « l’Eau ophtalmique de Loche » [R 248 Marques pharmaceutiques]. In: Revue d'histoire de la pharmacie, 102e année, N. 387, 2015. pp. 464-467
rs9939609 in the FTO gene is associated with obesity but not with several biochemical parameters in Sardinian obese children
No full textSeveral studies have reported an association of the intronic single nucleotide polymorphism (SNP) rs9939609 of the fat mass and obesity-associated (FTO) gene with obesity and with a number of obesity-related features. We studied the association of rs9939609 with obesity in 912 obese children and adolescents (426 males and 486 females, mean ± SD age 10.5 ± 3.3 years) and in 543 normal weight subjects. A number of biochemical and clinical parameters was also evaluated in 700 of these patients. In the obese group, mean body mass index standard deviation score (BMI-SDS) was similar between the three genotypes. The A allele was present in 55% of the patients' and in 43% of controls' chromosomes. The distribution of heterozygotes was similar between patients and controls (47%), while the distribution of AA homozygotes was significantly higher in patients (31% vs. 20%). Logistic regression analysis on the genotypes yielded a χ(2) of 35.5 with an odds ratio of 1.6 (CI = 1.3-1.8), P < 1 × 10(-5) . None of the clinical and metabolic parameters tested was associated with the genotype. In conclusion, we have confirmed the strong association between FTO and obesity, and shown that only AA homozygotes are predisposed to develop obesity while TT homozygotes might be protected. Finally, we found no association between rs9939609 and a number of obesity-related abnormalities
Determinación de la cantidad de Polifenoles y su Actividad Antioxidante en el Zapallo Loche (Cucurbita moschata Duchesne) fresco, sancochado y frito procedente del departamento de Lambayeque.
No full textObjetivo: Determinar el contenido de polifenoles y su actividad antioxidante del zapallo loche (Cucurbita moschata Duchesne) fresco, sancochado y frito. Materiales y métodos: Estudio de tipo experimental in vitro. Los zapallos loches fueron obtenidos delGran Mercado Mayorista de Lima, ubicado en el distrito de Santa Anita, procedentes del departamento de Lambayeque. La muestra fue el extracto etanólico de zapallo fresco, sancochado y frito. Para la determinación de fenoles totales se utilizó el método espectrofotométrico desarrollado por Folin-Ciocalteu, en el cual los resultados se expresan como equivalente de ácido gálico. Por otro lado, para la determinación de la capacidad antioxidante se utilizó el método desarrollado por Brand-Williams basado en la reducción del radical 2,2-difenil-1-picrilhidrazilo (DPPH). Resultados: El contenido de polifenoles en el zapallo loche fresco (103.869 mg ácido gálico/ 100g muestra) fue mayor que en el zapallo loche sancochado (48.000 mg ácido gálico/ 100g muestra), seguido del zapallo loche frito (43.804 mg ácido gálico/ 100g muestra). La capacidad antioxidante del zapallo loche sancochado destacó ya que inhibió en un 95% a los radicales libres, comparado con zapallo loche frito (86%) y zapallo loche fresco (80%). Conclusión: El zapallo loche fresco presenta mayor cantidad de polifenoles.El zapallo loche sancochado tiene una mayor capacidad antioxidante para inhibir los efectos de los radicales libres. Palabras Claves: Zapallo loche, actividad antioxidante, polifenoles, fenoles totales, DPPH.Tesi
An INSIG2 polymorphism affects glucose homeostasis in Sardinian obese children and adolescents
No full textAllelic variants of a single nucleotide polymorphism (SNP), rs7566605, located approximately 10 kb upstream of the INSIG2 gene have been found in association with body weight and with other clinical features related to obesity in some populations but not in others. Our objective was to test the association of this SNP in obese children and adolescents from the genetically isolated population of Sardinia. We tested the association of rs7566605 with body mass index (BMI) and with serum glucose and insulin concentrations and a surrogate measure of insulin resistance (HOMA-IR) in a cohort of 747 Sardinian obese children and adolescents. A case control analysis was performed using 548 ethnically-matched healthy controls. Allelic frequencies of the SNP were similar between patients and controls. Mean glucose and insulin concentration and mean HOMA-IR values were significantly higher in patients carrying the CC genotype than in the CG and GG carriers. In the patients with impaired fasting glucose (IFG) and/or impaired glucose tolerance (IGT), allele C was significantly more frequent than in controls. Although INSIG2 polymorphisms do not consistently associate with BMI, the observation of an association with glucose concentration would support a role for this gene in the metabolic complications of obesity
Allelic variants of INSIG2 gene are associated with glucose concentrations and HOMA-IR but not with BMI in Sardinian obese children and adolescents
No full textThe role of FTO genotype on eating behavior in obese Sardinian children and adolescents
No full textAim: We aimed to study the influence of the fat mass and obesity-associated ( FTO ) gene on eating behavior in 412 obese Sardinian children and adolescents. Genome-wide association studies (GWAS) have identified several susceptibility loci for obesity. Among these, the polymorphisms in the intron 1 of the FTO gene has been found associated to weight gain and obesity in various populations. Methods : All obese patients were genotyped for the FTO single nucleotide polimorphysm (SNP) rs9939609. In all subjects we evaluated eating behavior using the Child Eating Behaviour Questionnaire (CEBQ). Results: We found no differences in eating behavior according to the genotype, either in the entire cohort, or when subjects were subdivided into four different age groups. Conclusions: FTO genotype is associated with body mass index but does not influence eating behavior in a selected cohort of obese children from the isolated genetic population of Sardinia
- …
